Search results for "120"
showing 10 items of 581 documents
Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration
2011
P120RasGAP competes with Rab21 for binding to the cytoplasmic domain of integrin α-subunits, thereby promoting receptor escape from early endosomes and recycling to the plasma membrane.
The Histone Deacetylase Inhibitor JAHA Down-Regulates pERK and Global DNA Methylation in MDA-MB231 Breast Cancer Cells
2015
The histone deacetylase inhibitor N-1-(ferrocenyl)-N-8-hydroxyoctanediamide (JAHA) down-regulates extracellular-signal-regulated kinase (ERK) and its activated form in triple-negative MDA-MB231 breast cancer cells after 18 h and up to 30 h of treatment, and to a lesser extent AKT and phospho-AKT after 30 h and up to 48 h of treatment. Also, DNA methyltransferase 1 (DNMT1), 3b and, to a lesser extent, 3a, downstream ERK targets, were down-regulated already at 18 h with an increase up to 48 h of exposure. Methylation-sensitive restriction arbitrarily-primed (MeSAP) polymerase chain reaction (PCR) analysis confirmed the ability of JAHA to induce genome-wide DNA hypomethylation at 48 h of expos…
Nursing interventions of choice for the prevention and treatment of suicidal behaviour: The umbrella review protocol
2022
Abstract Aim To determine which interventions, from a nursing perspective, can be considered as the interventions of choice for the prevention and treatment of suicidal behaviour. In this way, the umbrella review attempts to identify nursing interventions from the Nursing Interventions Classification (NIC) taxonomy with evidence for this purpose. Design Descriptive study protocol. Methods This umbrella review will consist of an extensive, systematic search of published systematic reviews and meta‐analyses of studies examining interventions of choice for the prevention and treatment of suicidal behaviour. A systematic search of papers indexed in PubMed, CINAHL, Cochrane Database of Systemati…
In Vitro Evaluation of the Biological Effects of ACTIVA Kids BioACTIVE Restorative, Ionolux, and Riva Light Cure on Human Dental Pulp Stem Cells
2019
This study aimed to analyze the biological effects of three new bioactive materials on cell survival, migration, morphology, and attachment in vitro. ACTIVA Kids BioACTIVE Restorative (Pulpdent, Watertown, MA, USA) (Activa), Ionolux (Voco, Cuxhaven, Germany), and Riva Light Cure UV (SDI, Bayswater, Australia) (Riva) were handled and conditioned with a serum-free culture medium. Stem cells from human dental pulp (hDPSCs) were exposed to material extracts, and metabolic activity, cell migration, and cell morphology were evaluated. Cell adhesion to the different materials was analyzed by scanning electron microscopy (SEM). The chemical composition of the materials was evaluated by energy-dispe…
The relationship between out-of-school sport participation and positive youth development
2012
Carreres-Ponsoda F, Escarti A, Cortell-Tormo JM, Fuster-Lloret V, Andreu-Cabrera E. The relationship between out-of-school sport participation and positive youth development. J. Hum. Sport Exerc. Vol. 7, No. 3, pp. 671-683, 2012. Despite growing evidence that participation in out-of-school activities and especially physical activity and sport programs facilitates positive development, little developmental research has been conducted on out-of-school sports programs compared with no participation in these activities or participation in other activities. Our study examined the participation of youth in out of school sport activities compared with participation in other out-of-school activitie…
Habilitats de visualització manifestades per alumnes de primària quan resolen activitats de geometria 3D i la seua relació amb el talent matemàtic
2016
Aquesta investigació ha estat motivada per la importància de la visualització per comprendre millor el món que ens envolta, fet que contrasta amb la realitat a l’escola, on no se li dóna la consideració necessària. D’altra banda, també ens han preocupat els alumnes amb talent matemàtic, ja que reben una atenció molt deficient en les aules ordinàries. En aquest sentit, aquesta investigació té per objectius generals oferir un material educatiu caracteritzat per l’ús de diferents materials manipulatius que ajuden a l’alumnat amb diferents graus de talent matemàtic a manifestar les seues habilitats de visualització (Del Grande, 1990) i característiques de talent matemàtic. Els objectius concret…
Microscopic Origins of the Anomalous Melting Behavior of Sodium under High Pressure
2012
X-ray diffraction experiments have shown that sodium exhibits a dramatic pressure-induced drop in melting temperature, which extends from 1000 K at ~30 GPa to as low as room temperature at ~120 GPa. Despite significant theoretical effort to understand the anomalous melting, its origins are still debated. In this work, we reconstruct the sodium phase diagram by using an ab initio quality neural-network potential. Furthermore, we demonstrate that the reentrant behavior results from the screening of interionic interactions by conduction electrons, which at high pressure induces a softening in the short-range repulsion.
Combinations of discourse markers with repairs and repetitions in English, French and Spanish
2020
Abstract Discourse markers have a central role in planning and repairing processes of speech production. They relate with fluency and disfluency phenomena such as pauses, repetitions and reformulations. Their polyfunctionality is challenging and few form-function mappings are stable cross-linguistically. This study combines a functional and a structural approach to discourse markers and their combination with and within repetitions and self-repairs in native English, French and Spanish, in order to establish the inter-relation between these three fluency-related devices and to find potentially universal patterns of use. Qualitative coding and quantitative analyses of categories of markers a…
Targeted steel frames by means of innovative moment resisting connections
2021
Abstract The present paper proposes the use of stepped cross section devices on steel frames aiming at reproducing a pre-established target push-over curve. To this aim a Limited Resistance Plastic Device (LRPD) to be inserted along selected structural members is proposed. The following two main specific features for LRPD are required: any elastic flexural stiffness variation of the original selected member must be avoided; an ultimate plastic bending moment value equal to an assigned percentage of the original limit resistance value must be ensured. Steel frames equipped with LRPD are modeled by means of an extension of a recently proposed Fibre Smart Displacement Based (FSDB) beam element…
An In Vitro Stereomicroscopic Evaluation of Bioactivity between Neo MTA Plus, Pro Root MTA, BIODENTINE & Glass Ionomer Cement Using Dye Penetrati…
2021
The ideal root end filling material should form a tight seal in the root canal by adhering to the cavity walls. Several materials have been used for root end filling. The present study aims to find out and compare the bioactivity of Neo MTA Plus, Pro Root MTA White, BIODENTINE & glass ionomer cement as root end filling materials using 1% methylene blue as tracer. Materials and methods: 80 extracted human permanent maxillary anterior teeth were used in the study. They were divided into four groups. Specimens were sectioned transversely in the cervical area to separate the crown from the root. The root canal was obturated with gutta percha and zinc oxide eugenol sealers. Thereafter, each …