Search results for "14"
showing 10 items of 9841 documents
Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents
2022
Over the last decade, several compounds have been identified for the treatment of obesity. However, due to the complexity of the disease, many pharmacological interventions have raised concerns about their efficacy and safety. Therefore, it is important to discover new factors involved in the induction/progression of obesity. Adipose stromal/stem cells (ASCs), which are mostly isolated from subcutaneous adipose tissue, are the primary cells contributing to the expansion of fat mass. Like other cells, ASCs release nanoparticles known as extracellular vesicles (EVs), which are being actively studied for their potential applications in a variety of diseases. Here, we focused on the importance …
A common biological basis of obesity and nicotine addiction
2013
Contains fulltext : 128630.pdf (Publisher’s version ) (Open Access) Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked …
Adipokines in obesity and metabolic diseases
2020
Adipose tissue secretes many adipokines that regulate important physiological functions. Growing studies have highlighted that these bioactive molecules may contribute to the development of metabolic and cardiovascular diseases. Adipokines exert systemic metabolic effects and independent activity on numerous cells of the cardiovascular system, including cardiomyocytes and vascular cell walls. Adiponectin shows anti-inflammatory and anti-atherosclerotic activity on blood vessels. Conversely, resistin is endowed with pro-inflammatory effects and stimulates the proliferation of smooth muscle cells, thus promoting the development of atherosclerotic plaque. Leptin plays an important role in card…
Heritability of anterior chamber depth and axial length: a population-based twin study among 66 to 79-year old female twins.
2014
Bodies That Matter: Miniaturisation and the Origin(s) of ‘Art’
2020
Small things matter, especially in the so-called ‘arts’. From the visual arts to music and literature, ‘miniatures’ are a transcultural and transhistorical phenomenon that involves our aesthetic attitudes but also our everyday life, our emotional, social and cognitive life. Miniaturisation characterises our cognitive life and, of course, the ‘cognitive life of things’ that we produce, manipulate and discard. My paper is articulated into two sections: the first gives a quick overview of the miniatures of Homo sapiens, especially those of the paleolithic age, and a brief survey of the very challenging history of miniature-interpretation in twentieth-century philosophy of culture. In the secon…
Association between osteocalcin and cognitive performance in healthy older adults
2016
Everyday Life Meaningfulness for the Community-Dwelling Oldest Old During the COVID-19 Pandemic
2021
In many countries, the COVID-19 pandemic has led to strong restrictions and changed the everyday lives of older people. In Finland, people aged 70 and over were instructed to stay at home under quarantine-like conditions. Existing studies from other countries have reported increases in negative experiences and symptoms as a result of such restrictions, including psychosocial stress. However, little focus has been given to older people’s experiences of meaningfulness during the pandemic. Using survey and interview data, we ask to what extent have community-dwelling oldest old (80+) experienced meaningfulness during the pandemic, what background factors are associated with meaningfulness and …
Muistisairaiden ja puoliso-omaishoitajien kokemuksia tuen riittämättömyydestä
2021
Muistisairautta sairastavien ikääntyneiden kotona asuminen onnistuu usein omaishoitajien avulla, mutta tukea tarvitaan myös sosiaali- ja terveyspalveluista. Aina kaikki eivät kuitenkaan saa riittävää apua ja tukea. Niin muistisairautta sairastavat ihmiset kuin omaishoitajatkin voivat kärsiä avun riittämättömyydestä. Tässä artikkelissa tutkimme, millaista tukea muistisairaat ja heidän puolisonsa kaipaavat ja millaisia kokemuksia heillä on avun riittämättömyydestä. Tutkimuksemme mukaan muistisairautta sairastavien ikääntyneiden ja omaishoitajien kohtaama avun riittämättömyys liittyy sekä palvelujärjestelmään ja erilaisiin tukimuotoihin että henkisen tuen tarpeisiin. Muistisairautta sairastava…
FITOVIGILANZA: INTERAZIONI FARMACO-FITOTERAPICI IN PAZIENTI ONCOLOGICI ED IMMUNOCOMPROMESSI
2012
A reinvented archetype. The open-air theater on the edge of the city
2020
In southern Italy and in Sicily, over the past forty years, a series of urban redevelopment projects have been carried out, involving the construction of small theaters facing the Mediterranean landscape. !ey are re-invention projects of the archetype of the Greek theater that establish with the external landscape the same “sense of contemplation” expressed by the theaters of antiquity. Despite their privileged position, these theaters are occasionally used in the summer periods for tourist entertainment shows. Shows substantially distant from those of the past, as they lack an “educational” idea aimed at the construction of processes of self-recognition and identification.