Search results for "228"

showing 10 items of 834 documents

Benralizumab: From the Basic Mechanism of Action to the Potential Use in the Biological Therapy of Severe Eosinophilic Asthma

2018

Asthma is a very frequent chronic airway disease that includes many different clinical phenotypes and inflammatory patterns. In particular, eosinophilic bronchial inflammation is often associated with allergic as well as nonallergic asthma. The most important cytokine involved in the induction, maintenance, and amplification of airway eosinophilia in asthma is interleukin-5 (IL-5), released by both T helper 2 (Th2) lymphocytes and group 2 innate lymphoid cells (ILC2). Hence, IL-5 and its receptor are suitable targets for selective biologic drugs which can play a key role in add-on treatment of severe eosinophilic asthma refractory to corticosteroids. Within such a context, the anti-IL-5 mon…

Genetics and Molecular Biology (all)0301 basic medicineImmunology and Microbiology (all)lcsh:MedicineReview ArticleAntibodies Monoclonal HumanizedBiochemistryAntibodiesGeneral Biochemistry Genetics and Molecular Biology03 medical and health scienceschemistry.chemical_compoundTh2 Cells0302 clinical medicineReslizumabMonoclonalEosinophilicmedicineAnimalsHumansEosinophiliaHumanizedInterleukin 5AsthmaGeneral Immunology and Microbiologybusiness.industrylcsh:RInnate lymphoid cellGeneral Medicinemedicine.diseaseBenralizumabAsthmarespiratory tract diseasesBiological Therapy030104 developmental biology030228 respiratory systemchemistryImmunologyInterleukin-5medicine.symptombusinessMepolizumabAnimals; Antibodies Monoclonal Humanized; Asthma; Biological Therapy; Humans; Interleukin-5; Th2 Cells; Biochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)medicine.drug
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WITHDRAWN: Scaling up strategies of the Chronic Respiratory Disease programme of the European Innovation Partnership on Active and Healthy Ageing (Ac…

2017

Gerontologymedicine.medical_specialtybusiness.industryRespiratory diseaseAlternative medicinemedicine.disease03 medical and health sciences0302 clinical medicine030228 respiratory systemGeneral partnershipAction planmedicineGeneral Earth and Planetary Sciences030212 general & internal medicineHealthy ageingbusinessGeneral Environmental ScienceAlergologia Polska - Polish Journal of Allergology
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Hämodynamische Definition der pulmonalen Hypertonie: Kommentar zu der vorgeschlagenen Änderung durch das 6th World Symposium on Pulmonary Hypertension

2019

ZusammenfassungDie Ende 2015 veröffentlichten ESC/ERS-Leitlinien und andere internationale Empfehlungen definierten die pulmonale Hypertonie (PH) bisher durch einen invasiv gemessenen mittleren pulmonal arteriellen Druck (mPAP) ≥ 25 mmHg in Ruhe. Auf dem 6th World Symposium on Pulmonary Hypertension in Nizza wurde eine Modifikation dieser hämodynamischen Definition im Sinne einer Senkung des Schwellenwertes auf > 20 mmHg vorgeschlagen. Für die präkapilläre PH wird zusätzlich ein pulmonaler Gefäßwiderstand (PVR) ≥ 3 Wood-Einheiten (WE) gefordert. Diese Änderung muss im Hinblick auf die zugrunde liegende Rationale und mögliche Konsequenzen kritisch hinterfragt werden; es bedarf daher einer…

Gynecology03 medical and health sciencesmedicine.medical_specialty0302 clinical medicine030228 respiratory systembusiness.industryMedicineGeneral Medicine030204 cardiovascular system & hematologybusinessddc:DMW - Deutsche Medizinische Wochenschrift
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Hauttestungen mit Nahrungsmittelallergenen

2008

Hauttestungen haben einen zentralen Stellenwert in der Abklarung von Sensibilisierungen bei Nahrungsmittelallergien. Insbesondere der Pricktest stellt eine Routinemethode dar. Allerdings komplizieren instabile Allergene und das Fehlen standardisierter Extrakte das diagnostische Vorgehen bei Verdacht auf eine Nahrungsmittelallergie. Deswegen ist man nach wie vor auf einen Prick-zu-Prick-Test mit nativen Lebensmitteln angewiesen. Indikationen und Kontraindikationen fur eine Hauttestung mit Nahrungsmittelallergenen unterscheiden sich nicht wesentlich von anderen Allergien. Vorsicht ist bei Zustand nach schwerer anaphylaktischer Reaktion und bei bekannter hoher allergener Potenz der Nahrungsmit…

Gynecologymedicine.medical_specialtyAllergybusiness.industrydigestive oral and skin physiologySkin testDermatologymedicine.diseaseDermatology030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicine030228 respiratory systemFood allergymedicineImmunology and AllergyIn patientbusinessAnaphylaxisJDDG: Journal der Deutschen Dermatologischen Gesellschaft
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Prevalence and 30-Day Mortality in Hospitalized Patients With Covid-19 and Prior Lung Diseases.

2021

Patients with pre-existing respiratory diseases in the setting of COVID-19 may have a greater risk of severe complications and even death.A retrospective, multicenter, cohort study with 5847 COVID-19 patients admitted to hospitals. Patients were separated in two groups, with/without previous lung disease. Evaluation of factors associated with survival and secondary composite end-point such as ICU admission and respiratory support, were explored.1,271 patients (22%) had a previous lung disease, mostly COPD. All-cause mortality occurred in 376 patients with lung disease (29.5%) and in 819 patients without (17.9%) (Previous lung disease is a risk factor for mortality in patients with COVID-19.…

HOPE-COVID-19 Health Outcome Predictive Evaluation for COVID-19Respiratory diseasesOriginal30-Day mortalityenfermedades respiratoriasACE2 angiotensin converting enzyme IIlaw.invention0302 clinical medicineCQ/HCQ chloroquine/hydroxychloroquinelawCOPDrespiratory diseasesPrognosisICU intensive care unitIntensive care unitSTROBE strengthening the reporting of observational studies in epidemiologypronósticomedicine.anatomical_structureEPOCCohort studyPulmonary and Respiratory Medicinemedicine.medical_specialty30-day mortalityRT-PCR real time reverse transcriptase-polymerase chain reactionSARS-CoV-2 severe acute respiratory syndrome coronavirus 2WHO World Health OrganizationMERS middle east respiratory syndrome03 medical and health sciencesInternal medicinemedicineCOPDCOVID-19 2019 novel coronavirusRisk factorIQR interquartile rangeLungmortalidad a 30 díasbusiness.industryFEV1 forced expiratory volume in one secondCOVID-19Retrospective cohort studymedicine.diseaseHR hazard ratioICS inhaled corticosteroidsCI confidence intervalCoronavirusCOPD chronic obstructive pulmonary disease030228 respiratory systemRespiratory failureILD interstitial lung diseaseMiddle East respiratory syndromeprognosisHFNC high flow nasal cannulabusiness
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What Is the Role of Minimally Invasive Mitral Valve Surgery in High-Risk Patients? A Meta-Analysis of Observational Studies

2016

Background. Minimally invasive valve surgery is related to certain better postoperative outcomes. We aimed to assess the role of minimally invasive mitral valve surgery in high-risk patients. Methods. A systematic literature review identified eight studies of which seven fulfilled criteria for metaanalysis. Outcomes for a total of 1,254 patients (731 were conventional standard sternotomy and 523 were minimally invasive mitral valve surgery) were submitted to meta-analysis using random effects modeling. Heterogeneity and subgroup analysis with quality scoring were assessed. The primary end point was early mortality. Secondary end points were intraoperative and postoperative outcomes and long…

Heart Valve Diseases030204 cardiovascular system & hematologyGlobal HealthWMD weighted mean differencelaw.inventionPostoperative Complications0302 clinical medicineRisk FactorslawMitral valveCPB cardiopulmonary bypaStrokeHeart Valve Prosthesis ImplantationMedicine (all)Abbreviations and Acronyms AF atrial fibrillation; CI confidence interval; CPB cardiopulmonary bypass; MIMVS minimally invasive mitral valve surgery; OR odds ratio; PRC packed red cells; ST sternotomy; WMD weighted mean difference; Global Health; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Humans; Minimally Invasive Surgical Procedures; Mitral Valve; Postoperative Complications; Risk Factors; Survival Rate; Observational Studies as Topic; Risk Assessment; Cardiology and Cardiovascular Medicine; Surgery; Pulmonary and Respiratory Medicine; Medicine (all)Atrial fibrillationSurvival RateHeart Valve DiseaseObservational Studies as Topicmedicine.anatomical_structureCardiologyMitral ValveCardiology and Cardiovascular MedicineHumanPulmonary and Respiratory Medicinemedicine.medical_specialtyAbbreviations and Acronyms AF atrial fibrillationSubgroup analysisRisk Assessment03 medical and health sciencesST sternotomyInternal medicinePRC packed red cellmedicineCardiopulmonary bypassHumansMinimally Invasive Surgical ProceduresSurvival ratebusiness.industryCI confidence intervalRisk FactorMinimally Invasive Surgical ProcedureOdds ratioOR odds ratiomedicine.diseaseConfidence intervalSurgeryMIMVS minimally invasive mitral valve surgery030228 respiratory systemSurgeryPostoperative ComplicationbusinessThe Annals of Thoracic Surgery
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Urticaria in children and adolescents: An updated review of the pathogenesis and management

2018

The present survey represents the latest data on diagnosis and management of childhood urticaria. It has been observed that urticaria occurs less often in children than adults, with symptoms rarely lasting for over 6 weeks. Triggers or aggravating factors can be found only in 21%-55% of cases. Finding autoantibodies in children does not impact a disease prognosis, unlike in adult patients, where the presence of autoantibodies is associated with a more prolonged run of the disease, a more severe prognosis and more intensive treatment methods. The incidence of food allergy equals to 8%-10% of cases. The incidence of Helicobacter Pylori infection in children is lower than that in adults and co…

Helicobacter pylori infectionPediatricsmedicine.medical_specialtyAdolescentUrticariaImmunologyOmalizumabDiseaseDiagnosis DifferentialPathogenesis03 medical and health sciences0302 clinical medicineFood allergyAnti-Allergic AgentsmedicineHumansImmunology and Allergy030212 general & internal medicineAggravating FactorChildbusiness.industryIncidence (epidemiology)Prognosismedicine.disease030228 respiratory systemChronic DiseasePractice Guidelines as TopicPediatrics Perinatology and Child HealthEtiologybusinessmedicine.drugPediatric Allergy and Immunology
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Hypersensibilité immédiate au carboplatine ou à l’oxaliplatine : réintroduction du cisplatine sans tests cutané ?

2017

International audience; Introduction : L’incidence des réactions d’hypersensibilité immédiate aux sels de platine (cisplatine, carboplatine et oxaliplatine) augmente avec leur large utilisation en cancérologie. Les objectifs de cette étude étaient d’établir la fréquence des sensibilités croisées entre les sels de platine, de déterminer si le cisplatine peut être utilisé sans test allergologique préalable en cas d’allergie immédiate au carboplatine ou à l’oxaliplatine et enfin de proposer une prise en charge simple pour retraiter rapidement les malades.Méthodes : Notre étude rétrospective a porté sur 155 malades ayant présenté une réaction d’hypersensibilité immédiate à un sel de platine. De…

Hypersensibilité allergiqueCarboplatine[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract3. Good health030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicine030228 respiratory systemSels de platineImmunology and Allergy[ SDV.MHEP.DERM ] Life Sciences [q-bio]/Human health and pathology/DermatologyOxaliplatine[ SDV.MHEP.PSR ] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract[SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
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Asthma and Chronic Obstructive Pulmonary Disease in the Elderly: What is New Under the Sun?

2017

Hypersensitivity Immediatemedicine.medical_specialtyPatientsbusiness.industryPulmonary diseaseSettore MED/10 - Malattie Dell'Apparato Respiratoriomedicine.diseaseAsthma03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicine030228 respiratory systemSpirometryInternal medicineMedicineImmunology and AllergyHumans030212 general & internal medicinebusinessAsthmaAgedThe journal of allergy and clinical immunology. In practice
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Update I. A systematic review on the efficacy and safety of chloroquine/hydroxychloroquine for COVID-19

2020

Purpose To assess efficacy and safety of chloroquine (CQ)/hydroxychloroquine (HCQ) for treatment or prophylaxis of COVID-19 in adult humans. Materials and methods MEDLINE, PubMed, EMBASE and two pre-print repositories (bioRxiv, medRxiv) were searched from inception to 8th June 2020 for RCTs and nonrandomized studies (retrospective and prospective, including single-arm, studies) addressing the use of CQ/HCQ in any dose or combination for COVID-19. Results Thirty-two studies were included (6 RCTs, 26 nonrandomized, 29,192 participants). Two RCTs had high risk, two ‘some concerns’ and two low risk of bias (Rob2). Among nonrandomized studies with comparators, nine had high risk and five moderat…

ICU Intensive care unit;medicine.medical_treatmentCritical Care and Intensive Care MedicineRR Risk Ratio0302 clinical medicineChloroquineRCT Randomized clinical trialMedicineHCQ Hydroxychloroquine;Prospective StudiesProspective cohort studyChloroquine COVID-19 Hydroxychloroquine Mortality SARS-CoV-2ChloroquineECG Electrocardiogram;Rob2 Revised tool for Risk of Bias in randomized trials;CI Confidence interval;Coronavirus InfectionsPost-Exposure ProphylaxisHydroxychloroquinemedicine.drugmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)Pneumonia ViralMEDLINEContext (language use)Antiviral AgentsArticleWHO World Health OrganizationBetacoronavirus03 medical and health sciencesInternal medicineHumansMortalityCOVID-19 Coronavirus disease 2019;Post-exposure prophylaxisPandemicsRetrospective StudiesCQ Chloroquine;SARS-CoV-2ROBINS-I Risk of Bias in Non-randomized Studies of Interventions;business.industryCOVID-19030208 emergency & critical care medicineHydroxychloroquineRetrospective cohort studyHCWs Healthcare workers;NOS Newcastle Ottawa Scale;COVID-19 Drug Treatment030228 respiratory systembusinessHR Hazard Ratio;Journal of Critical Care
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