Search results for "231"
showing 10 items of 335 documents
Environmental risk factors of airborne viral transmission: Humidity, Influenza and SARS-CoV-2 in the Netherlands
2020
AbstractObjectiveThe relationship between specific humidity and influenza/SARS-CoV-2 in the Netherlands is evaluated over time and at regional level.DesignParametric and non-parametric correlation coefficients are calculated to quantify the relationship between humidity and influenza, using five years of weekly data. Bayesian spatio-temporal models—with a Poisson and a Gaussian likelihood—are estimated to find the relationship between regional humidity and the daily cases of SARS-CoV-2 in the municipalities and provinces of the Netherlands.ResultsAn inverse (negative) relationship is observed between specific humidity and the incidence of influenza between 2015 and 2019. The space-time anal…
La disciplina della responsabilità amministrativa delle società e degli enti
2010
Il capitolo tratta della disciplina della responsabilità amministrativa delle società e degli enti (D. Lgs. 231/2001), con specifico riguardo agli aspetti economico-aziendali. L’adozione e l’attuazione dei modelli organizzativi possono infatti rappresentare un interessante strumento a supporto della riduzione del rischio generale di impresa, e di controllo dei rischi particolari. Particolare attenzione viene inoltre posta sui più recenti contributi della dottrina giuridica ed economico-aziendale in argomento, e sulla disciplina dell’organismo di vigilanza. Si tratta della versione aggiornata dell'edizione 2010 del volume
Advances in plant materials, food by-products, and algae conversion into biofuels: use of environmentally friendly technologies
2019
Green technologies have emerged as useful tools for the generation of clean fuels with the potential to minimize the effect of human activity on the environment. Currently, these fuels are mainly composed of hydrocarbons obtained from crude oil. Over the past two decades, biomass has gained significant attention as a renewable feedstock for more sustainable biofuel production and has been a great candidate to replace fossil fuels. The principal components of most of the available biomass are cellulose, hemi-cellulose, and lignin. Although the available green technologies for biofuel production are progressing rapidly, productivity and chemical yield from these techniques are still below the…
New tricyclic systems as photosensitizers towards triple negative breast cancer cells.
2022
AbstractNineteen pyrrolo[1,2-h][1,7]naphthyridinones and pyrido[2,3-c]pyrrolo[1,2-a]azepinones were synthesized as new tricyclic systems in which the pyridine ring is annelated to the 6,7-dihydroindolizin-8(5H)-one and 5,6,7,8-tetrahydro-9H-pyrrole[1,2-a]azepine-9-one moieties to obtain potential photosensitizing agents. They were tested for their photoantiproliferative activity on a triple-negative breast cancer cell line, MDA-MB-231, in the dark and under UVA light (2.0 J/cm2). We demonstrated that their toxicity, only when exposed to light, was primarily due to the generation of reactive oxygen species while their photodegradation products were not responsible for their activity. The mos…
Servicios de intermediación en línea en Europa : diseño de un sistema específico de solución de controversias
2021
Este trabajo analiza el sistema de solución de controversias específicamente diseñado, con la introducción de alternativas a la jurisdicción, en el Reglamento (UE) 2019/1150 sobre el fomento de la equidad y la transparencia para los usuarios profesionales de servicios de intermediación en línea, que ha entrado recientemente en vigor.
Two New Alternatives to the Conventional Arm-in-Cage Test for Assessing Topical Repellents
2021
Abstract European guidelines for testing attractant and repellent efficacy (i.e., Product type 19 [PT19]) have been in revision since 2017. A key topic of discussion is the current approach to evaluating topical repellents. The European Chemical Agency has stated field testing should be avoided because of mosquito-borne disease risks. However, the most common laboratory method, the arm-in-cage (AIC) test, may limit the reliable extrapolation of lab results to field conditions. This study’s main goal was to assess alternative laboratory methods for evaluating topical mosquito repellents that use mosquito landing rates more representative of those in the field. The study took place at three E…
Capacity assessment for provision of quality sexual reproductive health and HIV-integrated services in Karamoja, Uganda
2020
Introduction: Sexual and reproductive health (SRH) and Human Immunodeficiency Virus (HIV) are crucial global health issues. Uganda continues to sustain a huge burden of HIV and AIDS.
 Methods: A cross-sectional health facility-based assessment was performed in November and December 2016 in Karamoja Region, northern Uganda. All the 126 health facilities (HFs) in Karamoja, including 5 hospitals and 121 Health Centers (HCs), covering 51 sub-counties of the 7 districts were assessed. We assessed the capacity of a) leadership and governance, b) human resource, c) service delivery, d) SRH and HIV service integration and e) users satisfaction and perceptions.
 Results: 64% of the establi…
Reproductive health problems in rural South African young women: risk behaviour and risk factors
2018
Background South African young women continue to be vulnerable, with high prevalence of teenage pregnancy, HIV, sexually transmitted infections (STIs) and female genital schistosomiasis (FGS). This study seeks to examine the underlying factors that may be associated with these four adverse reproductive health outcomes. Methods In a cross-sectional study of 1413 sexually active of young women, we explored these four adverse reproductive health outcomes by considering socio-demographic factors, socio-economic factors, sexual risk behaviour, substance abuse and knowledge about reproductive health by using a questionnaire. Consenting participants were asked about previous pregnancies and were t…
Candidatus Neoehrlichia mikurensis and Borrelia burgdorferi sensu lato detected in the blood of Norwegian patients with erythema migrans
2017
The most common tick-borne human disease in Norway is Lyme borreliosis. Ticks in Norway also harbour less known disease-causing agents such as Candidatus Neoehrlichia mikurensis, Borrelia miyamotoi and Rickettsia helvetica. However, human infections caused by these pathogens have never been described in Norway. The main aims of the study were to evaluate the contribution of several tick-borne bacterial agents, other than Borrelia burgdorferi sensu lato, to zoonotic diseases in Norway and to determine their clinical pictures. Blood samples from 70 symptomatic tick-bitten adults from the Agder counties in southern Norway were screened for seven tick-borne pathogens by using a commercial multi…
Epidemiological, clinical and genomic snapshot of the first 100 B.1.1.7 SARS-CoV-2 cases in Madrid
2021
A new SARS-CoV-2 variant, B.1.1.7, emerged in September in the UK, and is responsible for 76.6% of COVID-19 cases.1 This variant has also been reported in another 45 countries, 17 of them European.2,3 B.1.1.7 is considered to have higher transmissibility.4 It carries an unusually high number of specific mutations/deletions, 18, mostly non-synonymous and eight concentrate in the S gene,5 including several which might have relevant functional roles. The 69/70 deletion may be associated to immune response evasion6 and the N501Y substitution increases the affinity to the ACE2 receptor.7 These findings have raised the alarm of having to face a new variant with the potential to accelerate the spr…