Search results for "240"
showing 10 items of 1144 documents
Competitive interactions are mediated in a sex-specific manner by arbuscular mycorrhiza inAntennaria dioica
2017
Plants usually interact with other plants, and the outcome of such interaction ranges from facilitation to competition depending on the identity of the plants, including their sexual expression. Arbuscular mycorrhizal (AM) fungi have been shown to modify competitive interactions in plants. However, few studies have evaluated how AM fungi influence plant intraspecific and interspecific interactions in dioecious species. The competitive abilities of female and male plants of Antennaria dioica were examined in a greenhouse experiment. Females and males were grown in the following competitive settings: (i) without competition, (ii) with intrasexual competition, (iii) with intersexual competitio…
Sexes in gynodioeciousGeranium sylvaticumdo not differ in their isotopic signature or photosynthetic capacity
2017
• In gynodioecious plants, females are expected to produce more or better seeds than hermaphrodites in order to be maintained within the same population. Even though rarely measured, higher seed production can be achieved through differences in physiology. • In this work, we measured sexual dimorphism in several physiological traits in the gynodioecious plant Geranium sylvaticum. Photosynthetic rate, stomatal conductivity, transpiration rate, water use efficiency and isotopic signatures were measured in plants growing in two habitats differing in light availability. • Females have been reported to produce more seeds than hermaphrodites. However, we did not observe any significant difference…
The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.
2015
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine produced by auto-reactive T helper (Th) cells that initiate tissue inflammation. Multiple cell types can sense GM-CSF, but the identity of the pathogenic GM-CSF-responsive cells is unclear. By using conditional gene targeting, we systematically deleted the GM-CSF receptor (Csf2rb) in specific subpopulations throughout the myeloid lineages. Experimental autoimmune encephalomyelitis (EAE) progressed normally when either classical dendritic cells (cDCs) or neutrophils lacked GM-CSF responsiveness. The development of tissue-invading monocyte-derived dendritic cells (moDCs) was also unperturbed upon Csf2r…
Exclusive transduction of human CD4+ T Cells upon systemic delivery of CD4-targeted lentiviral vectors
2015
Abstract Playing a central role in both innate and adaptive immunity, CD4+ T cells are a key target for genetic modifications in basic research and immunotherapy. In this article, we describe novel lentiviral vectors (CD4-LV) that have been rendered selective for human or simian CD4+ cells by surface engineering. When applied to PBMCs, CD4-LV transduced CD4+ but not CD4− cells. Notably, also unstimulated T cells were stably genetically modified. Upon systemic or intrasplenic administration into mice reconstituted with human PBMCs or hematopoietic stem cells, reporter gene expression was predominantly detected in lymphoid organs. Evaluation of GFP expression in organ-derived cells and blood …
Identification of NY-ESO-1 epitopes presented by human histocompatibility antigen (HLA)-DRB4*0101-0103 and recognized by CD4(+) T lymphocytes of pati…
2000
NY-ESO-1 is a member of the cancer-testis family of tumor antigens that elicits strong humoral and cellular immune responses in patients with NY-ESO-1–expressing cancers. Since CD4+ T lymphocytes play a critical role in generating antigen-specific cytotoxic T lymphocyte and antibody responses, we searched for NY-ESO-1 epitopes presented by histocompatibility leukocyte antigen (HLA) class II molecules. Autologous monocyte-derived dendritic cells of cancer patients were incubated with recombinant NY-ESO-1 protein and used in enzyme-linked immunospot (ELISPOT) assays to detect NY-ESO-1–specific CD4+ T lymphocyte responses. To identify possible epitopes presented by distinct HLA class II allele…
Endringskapasitet – en nøkkel for å lykkes med gevinstrealisering i spesialisthelsetjenesten? : En studie av hvordan mellomledere opplever at endring…
2018
Masteroppgave i helse- og sosialinformatikk HSI500 - Universitetet i Agder 2018 Background: If an organisation is to reap the potential benefits of new technology, it must modify its work processes. However, the specialist health service appears to be experiencing significant challenges because it is constantly under pressure to change and improve its efficiency. This can weaken its capacity for change and, at worst, lead to long-term reductions in productivity and efficiency. Purpose: The purpose of this study is to examine how middle managers in the specialist health service feel they can influence developments in change capacity. The aim is to contribute to an awareness of the importance…
PUBLIC TRUST IN CHARITIES : EVIDENCES FROM FINLAND AND SWEDEN
2019
Master's thesis Innovative governance and public management ME523 - University of Agder 2019 Public sector across the globe is currently experiencing a decline in public trustand this issue has been widelydiscussed across the globe. While working as a fundraiser in summer 2018, the author discovered that charities are struggling to recruit and keep their regular donors. Donations from general people areone of the mainsources of charity funding. Individuals who donate to charities do not receive a direct benefit in exchange for their support to charities. Moreover, they don’t have all the necessary information, on which they can decide to donate. Trust is what facilitates the transactions be…
Spin doctoring in British and German election campaigns: How the press is being confronted with a new quality of political PR
2000
The 1997 British and 1998 German general elections showed striking parallels and distinctive differences in the way Blair and Schroeder delivered their campaigns and defeated long-sitting conservative governments. Of vital importance was a new quality of political public relations called `spin doctoring'. In this, the British Labour Party served as a kind of role model for the German Social Democratic Party. This article traces the origins and different meanings of `spin doctoring' in both countries, distinguishes between media-related and non-media-related spin activities and analyses it against the background of the specific national contexts. The aims and methods of political spin doctor…
Flernivåstaten og krisehåndtering: En kommentar
2022
Artikkelen diskuterer muligheter og utfordringer knyttet til koordinering på tvers av styringsnivåer. Utfordringen er minst tredelt: Dels knyttet til balansen mellom kontinuitet og endring, nærmere bestemt evnen offentlig forvaltning har til å balansere en stabil kjerne samtidig som den justerer, oppdaterer og reformerer; dels balansen mellom effektivitet og legitimitet, nærmere bestemt evnen til kortsiktig problemløsningen i møtet med kriser og langsiktige utfordringer knyttet til legitime løsninger generelt og parlamentarisk forankring konkret; dels dilemmaet mellom politisk-administrativ orden i turbulente tider, nærmere bestemt hvordan offentlige institusjoner håndterer kriser og vanske…
Sub-nasjonale styringsnivåer i et fler-nivå-administrativt system
2022
Denne artikkelen undersøker hvorvidt respondenter i norske fylkesadministrasjoner oppfatter at sentrale beslutninger influeres av eksterne aktører – gjennom vertikale relasjoner til sentraladministrative instanser og EU/EØS-institusjoner, samt horisontale relasjoner til andre fylkesadministrasjoner – og hvordan variasjonen i slike relasjoner kan forklares. Artikkelen bygger på data fra en ny spørreundersøkelse i norske fylkesadministrasjoner (N = 893), og viser hvordan fylkesadministrasjonene under visse betingelser kan opptre med to eller flere «hatter», det vil si at beslutningene som treffes influeres av flere eksterne aktører samtidig. Hovedtyngden av respondentene oppgir nasjonale sent…