Search results for "25"
showing 10 items of 3263 documents
IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia
2021
Simple Summary Although the prognosis of acute lymphoblastic leukemia (ALL) has improved significantly during the past decades, ALL remains a major cause of pediatric cancer mortality, and more accurate risk-stratification is required. We investigated IGF2BP3, which has previously been associated with aggressive cancers, and found high and subtype-specific expression of IGF2BP3 in B-cell ALL, that was associated with good outcome in high-risk patients. Results suggest that IGF2BP3 could be useful to improve stratification and prognosis of B-ALL. Abstract The oncofetal protein insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved i…
Aikuisten maahanmuuttajien kotoutumiskoulutuksen tulosten ennustaminen lähtötason arviointien perusteella
2017
Artikkelissa selvitetään aikuisten maahanmuuttajien kotoutumiskoulutuksessa saavuttamaa suomen kielen taitoa ja sitä, ennustaako koulutuksen alussa tehtävä lähtötason arviointi saavutettua kielitaitoa. Tutkimukseen osallistuneet maahanmuuttajat (N = 286) osallistuivat lähtötason arviointiin Testipisteessä. Sen jälkeen he suorittivat kotoutumiskoulutuksen opinnot peruspolun tai hitaan opintopolun mukaisesti muutamassa pääkaupunkiseudun oppilaitoksessa. Testipisteen mallin mukaisessa lähtötason arvioinnissa selvitetään maahanmuuttajan suomen kielen taitoa ja opiskeluvalmiuksia testeillä ja taustatietoja keräämällä. Niiden pohjalta maahanmuuttaja ohjataan sopivimmalle opintopolulle ja kielitai…
Artificial cartilage bio-matrix formed of hyaluronic acid and Mg2+-polyphosphate.
2016
Here we show that inorganic polyphosphate (polyP), a polyanionic metabolic regulator consisting of multiple phosphate residues linked by energy-rich phosphoanhydride bonds, is present in the synovial fluid. In a biomimetic approach, to enhance cartilage synthesis and regeneration, we prepared amorphous polyP microparticles with Mg2+ as counterions. The particles were characterised by X-ray diffraction (XRD), energy-dispersive X-ray (EDX) and Fourier transformed infrared spectroscopic (FTIR) analyses. Similar particles were obtained after addition of Mg2+ ions to a solution containing hyaluronic acid, as a major component of the synovial fluid, and soluble Na-polyP. The viscous paste-like ma…
¿Cómo se trata el tiempo atmosférico y el clima en la Educación Primaria? Una exploración a partir de los recursos y actividades de los manuales de t…
2020
El estudio del clima y del tiempo atmosférico constituye una tarea fundamental en la formación del alumnado (en todos sus niveles) debido a la enorme transcendencia social que tiene para gran parte de las actividades cotidianas. El objetivo de esta investigación es analizar los recursos y actividades sobre Climatología que se proponen en los manuales de texto de Primaria (3er Ciclo; Ciencias Sociales) de la Comunidad Valenciana (España). Metodológicamente se han consultado las principales editoriales que se utilizan en esta región. Los resultados indican que actualmente los libros de texto son meramente informativos y transmisivos. Respecto a los recursos, gran parte de los que se utilizan …
Rhombi-chain Bose-Hubbard model: Geometric frustration and interactions
2018
We explore the effects of geometric frustration within a one-dimensional Bose-Hubbard model using a chain of rhombi subject to a magnetic flux. The competition of tunnelling, self-interaction and magnetic flux gives rise to the emergence of a pair-superfluid (pair-Luttinger liquid) phase besides the more conventional Mott-insulator and superfluid (Luttinger liquid) phases. We compute the complete phase diagram of the model by identifying characteristic properties of the pair-Luttinger liquid phase such as pair correlation functions and structure factors and find that the pair-Luttinger liquid phase is very sensitive to changes away from perfect frustration (half-flux). We provide some propo…
Relación entre características de resiliencia, estrés parental y satisfacción con la vida en familias con hijos con TDAH
2016
Abstract.This paper addresses two aims: a) to analyze differences in the stress of parents of children and adolescents with ADHD with high and low scores on success atributes related to resilience; b) to study the relationship between these success attributes and the level of success of life satisfaction of children in different domains. For this, 46 families completed the questionnaires of Assessment Attributes Success, the domain’s Father Parenting Stress Index and Life Satisfaction Scales. The statistical analysis demonstrated significant differences in the parenting stress of children with ADHD and low and high scores on the attributes of self-awareness, proactivity, perseverance and go…
Was Frank Knight an institutionalist?
2005
This paper critically examines Geoffrey Hodgson's recent provocative claim about Frank Knight as being a member of American institutionalism in the interwar years. In the first section of the paper the authors attempt to provide a definition of institutionalism and to emphasize its meaning from a historiographic point of view. The second and third sections analyze the two main methodological struggles between Knight and the institutionalists, namely, the debate during the early 1020s over the use of instinct theory as an explanation of economic behavior, and the subsequent campaign led by Knight in the late 1920s and early 1930s against the behaviorist wing of American institutionalism à la…
Plagiarism and predatory journals: A threat to scientific integrity
2018
This article presents an analysis of the concept of plagiarism in order to show the wide spectrum of manifestations that can be considered as such when committing a transgression of intellectual property, carried out with the intention of deceiving the authors’ true contribution and the originality and novelty of the information. It describes the different circumstances in which intentional plagiarism has occurred, and the damage that this misconduct causes in the credibility of the scientific system, in which authorship credit is the foundation of the academic career, of the prestige of the author in the scientific community, and the basis for financing research. Some circumstances are fav…
Individual differences in behavioral consistency are related to sequential access to resources and body condition in a producer-scrounger game
2014
Investigating the evolution of consistent between-individual behavioral differences necessitates to explain the emergence of within-individual consistency. Relying on a recent mathematical model, we here test the prediction that the emergence of differences in within-individual consistency is related to the sequential access to resources in a frequency-dependent foraging game. To this end we used flocks of zebra finches (Taeniopygia guttata) engaged in a producer-scrounger foraging game. Tactic investment (i.e., the proportion of hops with the head down) significantly predicted successful tactic use (i.e., the proportion of seeds produced). In support of predictions, we found that individua…
Effects of conversation content on viewing dyadic conversations
2016
People typically follow conversations closely with their gaze. We asked whether this viewing is influenced by what is actually said in the conversation and by the viewer’s psychological condition. We recorded the eye movements of healthy (N = 16) and depressed (N = 25) participants while they were viewing video clips. Each video showed two people, each speaking one line of dialogue about socio-emotionally important (i.e., personal) or unimportant topics (matter-of-fact). Between the spoken lines, the viewers made more saccadic shifts between the discussants, and looked more at the second speaker, in personal vs. matter-of-fact conversations. Higher depression scores were correlated with les…