Search results for "26"

Conciliation des traitements médicamenteux à l’admission : expérimentation en établissement de santé mentale et éligibilité des patients pouvant en b…

2017

Resume Introduction La mise en place de la conciliation des traitements medicamenteux (CTM) a effectifs constants necessite d’etre efficiente en definissant notamment des criteres d’eligibilite des patients. Materiel et methodes Une etude monocentrique observationnelle a ete menee en etablissement de sante mentale a titre experimental. Elle a pour objectif d’identifier les criteres d’eligibilite a la conciliation pour la mener en priorite chez les patients les plus a risque d’iatrogenie medicamenteuse et de permettre l’implantation d’un processus de conciliation efficient. Des criteres generaux (6), somatiques (14) et psychiatriques (15) potentiellement pertinents ont ete identifies et etud…

Inteligencia artificial, big data y aplicaciones contra la COVID-19: privacidad y protección de datos

2020

espanolEl big data y la IA han fracasado en la prevencion, pero pueden ser muy utiles frente a la COVID-19 e incluso para evitar confinamientos y otras restricciones de derechos que provoca. La IA puede ser extremadamente eficaz para integrar, estructurar y extraer informacion y conocimiento de ingente cantidad y variedad de big data para la investigacion biomedica. Tambien es util para mejorar la atencion e informacion ciudadana y de salud, la telemedicina y la mejor asignacion de los recursos humanos y materiales. Mas amenazante para la privacidad puede ser el desarrollo de apps, pasaportes biologicos electronicos o sistemas de geolocalizacion, trazabilidad y monitoreo de personas impleme…

Évaluation des coûts médicamenteux évités grâce aux inclusions des patients atteints d’hémopathie maligne dans les essais cliniques

2020

Resume Introduction Les essais cliniques (EC) sont indispensables pour evaluer l’efficacite et l’innocuite de nouveaux traitements. Ils peuvent representer une mesure d’economie grâce a la fourniture des medicaments par le promoteur. Objectif L’objectif de cette etude est d’evaluer les couts evites en medicament hors-GHS ou sous Autorisation Temporaire d’Utilisation (ATU) par l’inclusion d’un patient dans un EC d’Hematologie. Materiels et methodes C’est une etude de cout, retrospective, monocentrique, observationnelle. La perspective de l’etude est elargie du point de vue de l’assurance maladie obligatoire. Nous avons inclus les EC d’Hematologie ayant eu au moins une dispensation entre 2007…

Taste Disturbance with Acetazolamide

1997

A population genomics analysis of the native Irish Galway sheep breed.

2019

SUMMARYThe Galway sheep population is the only native Irish sheep breed and represents an important livestock genetic resource, which is currently categorised as “at-risk”. In the present study, comparative population genomics analyses of Galway sheep and other sheep populations of European origin were used to investigate the microevolution and recent genetic history of the breed. These analyses support the hypothesis that British Leicester sheep were used in the formation of the Galway breed and suggest more recent gene flow from the Suffolk sheep breed. When compared to conventional and endangered breeds, the Galway breed was intermediate in effective population size, genomic inbreeding a…

Cold adaptation drives population genomic divergence in the ecological specialist, Drosophila montana

2020

Funding: UK Natural Environment Research Council (Grant Number(s): NE/L501852/1, NE/P000592/1); Academy of Finland (GrantNumber(s): 267244, 268214, 322980), Ella ja Georg Ehrnroothin Säätiö. Detecting signatures of ecological adaptation in comparative genomics is challenging, but analysing population samples with characterised geographic distributions, such as clinal variation, can help identify genes showing covariation with important ecological variation. Here, we analysed patterns of geographic variation in the cold-adapted species Drosophila montana across phenotypes, genotypes and environmental conditions and tested for signatures of cold adaptation in population genomic divergence. We…

Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate

2018

Literature and experimental data relevant to waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release solid oral dosage forms containing amoxicillin trihydrate are reviewed. Solubility and permeability characteristics according to the Biopharmaceutics Classification System (BCS), therapeutic uses, therapeutic index, excipient interactions, as well as dissolution and BE and bioavailability studies were taken into consideration. Solubility and permeability studies indicate that amoxicillin doses up to 875 mg belong to BCS class I, whereas 1000 mg belongs to BCS class II and doses of more than 1000 mg belong to BCS class IV. Considering all aspects, the biowaiver pro…

Cognate HLA absence in trans diminishes human NK cell education

2016

NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA– tumor cells during education for improved missing-self recognition. Here, we reconstituted mice with human hematopoietic cells from donors with homozygous KIR ligands or with a mix of hematopoietic cells from these homozygous donors, allowing assessment of the resulting KIR repertoire and NK cell education. We found that co-reconstitution with 2 KIR ligand–mismatched compartments did not alter the frequenc…

Computational processing and quality control of Hi-C, capture Hi-C and capture-C data

2019

Hi-C, capture Hi-C (CHC) and Capture-C have contributed greatly to our present understanding of the three-dimensional organization of genomes in the context of transcriptional regulation by characterizing the roles of topological associated domains, enhancer promoter loops and other three-dimensional genomic interactions. The analysis is based on counts of chimeric read pairs that map to interacting regions of the genome. However, the processing and quality control presents a number of unique challenges. We review here the experimental and computational foundations and explain how the characteristics of restriction digests, sonication fragments and read pairs can be exploited to distinguish…

Vitamin D receptor polymorphisms and 25-hydroxyvitamin D in a group of Sicilian multiple sclerosis patients

2016

Multiple sclerosis (MS) is an auto-immune disease whose etiology remains controversial. Both genetic and environmental factors are thought to be involved in the risk of developing the disease. The purpose of our study was to assess the association of Vitamin D receptor (VDR) polymorphisms with MS and to investigate the interaction of these polymorphisms with vitamin D levels. A total of 179 Sicilian subjects, including 104 MS patients and 75 healthy controls, were studied. The most common VDR polymorphisms (Fok-I, Bsm-I, Taq-I and Apa-I) were genotyped by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analyses in both groups and serum 25-hydroxyv…