Search results for "27"

Continuous subcutaneous Insulin infusion leads to immediate, table, and long-term changes in metabolic control

2008

Background:  Evaluations of continuous subcutaneous insulin infusion (CSII) usually focus on one pre- and one post-CSII measurement to assess metabolic therapy outcome. Aim:  Extending this research, the aim of the present study was to provide a more fine-grained analysis of achieved glycaemic control. Methods:  In 52 patients with type 1 diabetes (mean age of 37.85 years at CSII begin; s.d. ± 12.41), haemoglobin A1c (HbA1c) levels were assessed every 3 months over a period of 5 years (1 year before and 4 years after the introduction of CSII). Mixed models were utilized to describe changes in glycaemic control. Results:  The pre–post course showed that already in the first quarter, a statis…

Análisis edad-periodo-cohorte de la mortalidad por accidentes de tráfico en España

1999

OBJETIVO. Estudiar la evolución de la mortalidad por accidentes de tráfico en España y su posible aplicación a un modelo edad-periodo-cohorte, así como el efecto que pueden tener algunas medidas de seguridad vial seleccionadas. MATERIAL Y MÉTODOS. Se obtuvieron las tasas de mortalidad por accidentes de tráfico y las tasas en intervalos quinquenales de edad para cada sexo, lo que permite su estudio como tasas específicas de edad por cohortes de nacimiento. Para determinar la asociación entre las medidas de seguridad vial seleccionadas y la mortalidad se han construido modelos de regresión de Poisson. RESULTADOS. Se observaron dos ondas evolutivas en la mortalidad por accidentes de tráfico. R…

Dampness and student-reported social climate: two multilevel mediation models.

2021

Background Little previous research has analysed the relationship between schools' indoor air problems and schools' social climate. In this study, we analysed a) whether observed mould and dampness in a school building relates to students' perceptions of school climate (i.e. teacher-student relationships and class spirit) and b) whether reported subjective indoor air quality (IAQ) at the school level mediates this relationship. Methods The data analysed was created by merging two nationwide data sets: survey data from students, including information on subjective IAQ (N = 25,101 students), and data from schools, including information on mould and dampness in school buildings (N = 222). The …

Hydrothermal liquefaction of municipal sludge in sub- and super- critical water

2020

Hydrothermal liquefaction of municipal sludge was conducted to investigate the effects of sub- and supercritical water and of the fluid dynamic regime on the quality of the products. Preliminary experimental runs were performed at two different temperatures (350°C and 400°C) changing reaction time in order to work at fixed kinetic severity of the process. An improvement of the C content in the solid residues and of the ratio H/C of the biocrude was obtained when a stirred reactor was used both in sub- and supercritical water. A hydrocarbon fraction was separated from biocrude whose maximum yield of 25% w/w was achieved in supercritical conditions. Results showed that the cumulative energy r…

Hydrothermal liquefaction of wet waste biomass: a practical assessment to achieve an integral valorization of municipal sludge

2020

Hydrothermal liquefaction of municipal sludge was conducted to perform a practical assessment to achieve an integral valorization of this wet waste biomass. Experiments were done to investigate the effects of sub- and supercritical water and of the fluid dynamic regime on the energy recovery of the process and on the quality of the products. Experimental runs were performed at two different temperatures (350°C and 400°C) changing reaction time in order to work at the same kinetic severity of the process (LogR0=8.9, calculated as in ref. [3]). An improvement of the C % in the solid residues and of the ration of H/C of the biocrude was obtained when stirred reactor was used both in sub- and s…

Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases

2018

Since the discovery of HLA 60 years ago, it has contributed to the understanding of the immune system as well as of the pathogenesis of several diseases. Aside from its essential role in determining donor-recipient immune compatibility in organ transplantation, HLA genotyping is meanwhile performed routinely as part of the diagnostic work-up of certain autoimmune diseases. Considering the ability of HLA to influence thymic selection as well as peripheral anergy of T cells, its role in the pathogenesis of autoimmunity is understandable. The aim of this paper is to provide a brief overview of the role and current clinical relevance of HLA-B27 in spondyloarthritis and HLA-B51 in Behçet's disea…

2016

Objectives Human leukocyte antigen (HLA)-B27 (B27) is the strongest genetic factor associated with development of Ankylosing Spondylitis and other spondyloarthropathies (SpA), yet the role it plays in disease pathogenesis remains unclear. We investigated the expression of potentially pathogenic non-conventional heavy chain forms (NC) of B27 in synovial and intestinal tissues obtained from SpA patients. We also determined the presence of NC-B27 in joints, lymphoid and gastrointestinal tissue from B27 transgenic (TG1) rats with M.tuberculosis-induced SpA.

FRI0150 Mtor blockade by rapamycin decreases arthritis and spondylitis development and severity in hla-b27 transgenic rats

2018

Career situation of first and presenting author Student for a master or a PhD. Introduction TNF and IL-17A have been demonstrated as key inflammatory cytokines in Spondyloarthritis (SpA), whereas targeting bone remodeling remains an unmet clinical need in SpA. The mammalian target of rapamycin (mTOR) regulates IL-17 expression and osteogenesis and could therefore be a promising therapeutic target in SpA. Objectives To investigate if blockade of mTOR with rapamycin inhibits the pathological processes in inflammation and bone in SpA. Methods Cytokines were measured by ELISA in the supernatant from SpA patient PBMCs stimulated with anti-CD3/CD28, with various concentrations of rapamycin. SpA F…

HLA-B27-restricted T cells from patients with ankylosing spondylitis recognize peptides from B*2705 that are similar to bacteria-derived peptides

2003

SUMMARY Ankylosing spondylitis (AS) is an inflammatory systemic disease affecting the spine, sacroiliacal and peripheral joints. Although the aetiology of AS remains unknown, the strong association with the HLA-B27 allele might reflect directly a detrimental effect of the HLA-B27 molecule itself, resulting from its potential capability to present ‘arthritogenic’ peptides to CD8+ T cells. Because some forms of SpA are triggered by enterobacterial infection, such arthritogenic peptides might originate from autologous and/or bacterial proteins triggering cross-reactive CD8+ T cell clones. Intriguingly, two peptides from the second extracellular domain of HLA-B*2705 share sequence homologies wi…

HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis.

1993

Ankylosing spondylitis and seronegative spondylarthropathies such as Reiter's syndrome and reactive arthritis are strongly associated with HLA-B27. However, the mechanisms by which HLA-B27 is involved in disease susceptibility and pathogenesis are unknown. If the disease association is a consequence of HLA-B27's physiological function in antigen presentation, the disease should be mediated by cytotoxic T lymphocytes (CTLs) that recognise bacterial or self peptides presented by HLA-B27. Proof of this arthritogenic peptide model requires isolation of B27-restricted CD8 T cells from arthritic joints of patients with spondylarthropathies. An important question is whether "arthritogenic" bacteri…