Search results for "29"
showing 10 items of 3100 documents
Effects of marathon fatigue on running kinematics and economy
2007
International audience; The influence of marathon fatigue on both running kinematics and economy was investigated with 8 subjects. The measurements included a treadmill test at 3 steady submaximal speeds performed before and after the marathon. One complete left leg cycle was videotaped at 100 Hz from the left side at each speed. The analysis included contact time (braking and push-off') and flight time as well as displacements and angular velocities of the left hip and knee. This analysis was complemented by the measurements of the electromyographic (EMG) activity of the gastrocnemius muscle at each running velocity, and energy expenditure (E) of the last 30.s at the 2 slowest speeds. The …
Three team and organisational culture myths and their consequences for sport psychology research and practice
2019
In this article, three prevailing myths about team and organisational culture – an increasingly popular topic in applied sport psychology research and practice – are identified, reviewed and challenged. These are; that culture is characterised only by what is shared, that culture is a variable and therefore something that a particular group has, and that culture change involves moving from the old culture to an entirely new one. We present a challenge to each myth through the introduction of alternative theoretical and empirical material and discuss the implications for sport psychology research and practice. The intent of this endeavour is to stimulate debate on how to best conceptualise a…
La participación de la ciudadanía en los procesos de diseño de las políticas públicas de empleo. El caso del litoral sur de Alicante
2019
La presente investigación tiene como finalidad describir cómo la ciudadanía ha contribuido a la elaboración de un Diagnóstico Territorial de Empleo (DET) promovido por la Generalitat Valenciana, previo al diseño de futuras políticas públicas para el fomento del empleo, en tres municipios alicantinos. Se consiguió a través de una Investigación-Acción-Participación (IAP). Se realizaron talleres participativos y grupos focales que sirvieron para que la ciudadanía conociese de la existencia del proyecto y sus fines, además de aportar su experiencia, opinión y plantear posibles soluciones a la problemática del empleo en estos municipios. Se puede concluir que la ciudadanía está capacitada para a…
Palliative sedation in advanced cancer patients followed at home: A retrospective analysis
2012
Abstract CONTEXT: Data regarding palliative sedation at home in dying patients are lacking. OBJECTIVES: To describe the frequency, indication, and modality of palliative sedation (PS) in patients followed at home. METHODS: A retrospective analysis of home care cancer patients was performed. Patients who received PS before dying were selected and information about epidemiologic characteristics, indications, duration, drugs, and outcomes was collected. RESULTS: Of 370 medical charts of patients who died at home, 49 patients received PS before dying. PS was proposed by the team, relatives, or both in 63.3%, 4.1%, and 32.6% of cases, respectively. Delirium alone or in combination with other sym…
Palliative sedation in patients with advanced cancer followed at home: A systematic review
2011
Abstract Context Patients with advanced cancer who are near the end of life may experience intolerable suffering refractory to targeted palliative therapies. Palliative sedation (PS) is considered to be an effective treatment modality for these refractory symptoms when aggressive efforts fail to provide relief. Objectives The aim of this study was to systematically review articles regarding PS performed at home in patients with intractable symptoms. Methods Literature databases searched included MedLine, PubMed, and EMBASE. The text words and MeSH/EMTREE terms "home care" and "sedation" were used for electronic database searches. Results Six articles met the inclusion criteria for research …
Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.
2008
The receptor for advanced glycation end products (RAGE) is a 55-kDa type I membrane glycoprotein of the immunoglobulin superfamily. Ligand-induced up-regulation of RAGE is involved in various pathophysiological processes, including late diabetic complications and Alzheimer disease. Application of recombinant soluble RAGE has been shown to block RAGE-mediated pathophysiological conditions. After expression of full-length RAGE in HEK cells we identified a 48-kDa soluble RAGE form (sRAGE) in the culture medium. This variant of RAGE is smaller than a 51-kDa soluble version derived from alternative splicing. The release of sRAGE can be induced by the phorbol ester PMA and the calcium ionophore c…
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
2014
Activating mutations in genes encoding phosphatidylinositol 3-kinase (PI3K)-AKT pathway components cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH, OMIM 603387)(1-3). Here we report that individuals with MPPH lacking upstream PI3K-AKT pathway mutations carry de novo mutations in CCND2 (encoding cyclin D2) that are clustered around a residue that can be phosphorylated by glycogen synthase kinase 313 (GSK-3 beta)(4). Mutant CCND2 was resistant to proteasomal degradation in vitro compared to wild-type CCND2. The PI3K-AKT pathway modulates GSK-3 beta activity(4), and cells from individuals with PIK3CA, PIK3R2 or AKT3 mutations showed similar CCND2 accumulation. CCND…
Melatonin stimulates the nonamyloidogenic processing ofβAPP through the positive transcriptional regulation of ADAM10 and ADAM17
2014
Melatonin controls many physiological functions including regulation of the circadian rhythm and clearance of free radicals and neuroprotection. Importantly, melatonin levels strongly decrease as we age and patients with Alzheimer's disease (AD) display lower melatonin than age-matched controls. Several studies have reported that melatonin can reduce aggregation and toxicity of amyloid-β peptides that are produced from the β-amyloid precursor protein (βAPP). However, whether melatonin can directly regulate the βAPP-cleaving proteases ('secretases') has not been investigated so far. In this study, we establish that melatonin stimulates the α-secretase cleavage of βAPP in cultured neuronal an…
A New Mutation in the Promoter Region of the PAX8 Gene Causes True Congenital Hypothyroidism with Thyroid Hypoplasia in a Girl with Down's Syndrome
2014
Thyroid dysfunction is common in newborn infants with Down's syndrome (DS), but defects causing classic thyroid dysgenesis (TD) with permanent congenital hypothyroidism (CH) have not been described.We studied a girl with DS and CH who had a mutation in the promoter sequence of the PAX8 gene.A female infant was found to have trisomy 21 and CH, with a venous thyrotropin (TSH) of150 mU/L and a free thyroxine (fT4) of 15.1 pmol/L (day 12). Thyroid peroxidase antibodies and thyroglobulin antibodies were elevated. Scintigraphy showed normal uptake, but ultrasound identified a small gland with heterogenous echotexture and cystic changes. Sequence analysis of the PAX8 gene revealed a new heterozygo…
Effects of Individual Changes in Training Distribution on Maximal Aerobic Capacity in Well-Trained Cross-Country Skiers: A Follow-Up Study
2021
The purpose of this study was to evaluate individual changes in training distribution and the subsequent effects on maximal oxygen uptake (VO2max). The participants were well-trained cross-country skiers who had performed a year with no substantial changes in training prior to this study. Six cross-country skiers, who were participants in a larger previous study, volunteered for a follow-up study. All skiers performed self-motivated changes in training distribution for a new preparation period in this follow-up, generally by more high-intensity training (HIT). All training characteristics were registered from training diaries. During the follow-up period, all skiers performed an incremental…