Search results for "2D"
showing 10 items of 305 documents
2013
The MHC-class I (MHC-I)-like viral (MHC-Iv) m152 gene product of murine cytomegalovirus (mCMV) was the first immune evasion molecule described for a member of the β-subfamily of herpesviruses as a paradigm for analogous functions of human cytomegalovirus proteins. Notably, by interacting with classical MHC-I molecules and with MHC-I-like RAE1 family ligands of the activatory natural killer (NK) cell receptor NKG2D, it inhibits presentation of antigenic peptides to CD8 T cells and the NKG2D-dependent activation of NK cells, respectively, thus simultaneously interfering with adaptive and innate immune recognition of infected cells. Although the m152 gene product exists in differentially glyco…
2D motif basis applied to the classification of digital images
2016
The classification of raw data often involves the problem of selecting the appropriate set of features to represent the input data. Different types of features can be extracted from the input dataset, but only some of them are actually relevant for the classification process. Since relevant features are often unknown in real-world problems, many candidate features are usually introduced. This degrades both the speed and the predictive accuracy of the classifier due to the presence of redundancy in the set of candidate features. Recently, a special class of bidimensional motifs, i.e. 2D motif basis has been introduced in the literature. 2D motif basis showed to be powerful in capturing the r…
Motif patterns in 2D
2008
AbstractMotif patterns consisting of sequences of intermixed solid and don’t-care characters have been introduced and studied in connection with pattern discovery problems of computational biology and other domains. In order to alleviate the exponential growth of such motifs, notions of maximal saturation and irredundancy have been formulated, whereby more or less compact subsets of the set of all motifs can be extracted, that are capable of expressing all others by suitable combinations. In this paper, we introduce the notion of maximal irredundant motifs in a two-dimensional array and develop initial properties and a combinatorial argument that poses a linear bound on the total number of …
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ.
2013
Due to a unique pattern of CD8 T-cell response induced by cytomegaloviruses (CMVs), live attenuated CMVs are attractive candidates for vaccine vectors for a number of clinically relevant infections and tumors. NKG2D is one of the most important activating NK cell receptors that plays a role in costimulation of CD8 T cells. Here we demonstrate that the expression of CD8 T-cell epitope of Listeria monocytogenes by a recombinant mouse CMV (MCMV) expressing the NKG2D ligand retinoic acid early-inducible protein 1-gamma (RAE-1γ) dramatically enhanced the effectiveness and longevity of epitope-specific CD8 T-cell response and conferred protection against a subsequent challenge infection with List…
CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA)
2006
4-Methylthioamphetamine (4-MTA) belongs to a group of new amphetamine derivatives that is usually sold as "ecstasy" or "flatliners" on the illicit drug market. Large interindividual differences in 4-MTA mediated toxicity have been reported in humans. Therefore, we tested whether CYP2D6 or its variant alleles as well as CYP3A4 influence the susceptibility to 4-MTA. For this purpose, we used the colony formation assay with Chinese hamster lung fibroblast V79 cells expressing human wild-type CYP2D6 (CYP2D6*1), the low activity alleles CYP2D6*2, CYP2D6*9, as well as human CYP3A4. The obtained results showed that the expression of wild type CYP2D6*1 clearly enhanced the susceptibility to the cyt…
Glycated Albumin for Glycemic Control in T2DM Population: A Multi-Dimensional Evaluation.
2021
Lucrezia Ferrario,1 Fabrizio Schettini,1 Angelo Avogaro,2 Chiara Bellia,3 Federico Bertuzzi,4 Graziella Bonetti,5 Antonio Ceriello,6 Marcello Ciaccio,3,7 Massimiliano Corsi Romanelli,8,9 Elena Dozio,9 Luca Falqui,10 Angela Girelli,11 Antonio Nicolucci,12 Gianluca Perseghin,13,14 Mario Plebani,15 Umberto Valentini,11 Martina Zaninotto,15 Silvana Castaldi,9,16 Emanuela Foglia1 1Centre for Health Economics, Social and Health Care Management, Università Carlo Cattaneo - LIUC, Castellanza, Italy; 2Department of Medicine, University-Hospital of Padova, Padova, Italy; 3Section of Clinical Biochemistry and Clinical Molecular Medicine, Department of Biopathology and Medical Biotechnologie…
The relevant role of family history in predicting type 2 diabetes occurrence.
2019
On June 6, 2019, the Polish Archives of Internal Medicine published an interesting article by Szczerbiński et al,1 entitled “Efficacy of family history, genetic risk score, and physical activity in assessing the prevalence of type 2 diabetes.” This editorial is a commentary on this paper, intending to highlight, one more time, the importance of a positive family history (FH+) of type 2 diabetes (T2D) for estimating diabetes occurrence in the adult population as well as the importance of physical activity (PA) for maintaining optimal body composition and a low incidence rate of chronic disease.2 Since 2011, my research group has provided periodical pieces of evidence (2011, 2013, and 2014) a…
Variation of proteomic profile during lactation in Girgentana goat milk: a preliminary study
2019
The knowledge of milk proteome has been greatly enhanced by technological advances in the proteomics field as the use of the two-dimensional differential in-gel electrophoresis, a gel-based approach which allowed the analysis of proteins from complex mixtures and the comparing of several protein samples in the same experiment. The aim of this study was to characterise the whole milk proteomic profile in Girgentana dairy goat breed by two-dimensional differential in-gel elecrophoresis. The obtained representative 2D whole milk proteomic map showed a general picture of the protein distributions over the pH 3–10 NL including about 100 spots, most of them organised like a spot train. Among diff…
Divdimensionālās šķidruma hromatogrāfijas augstas izšķirtspējas masspektrometrijas metodes izstrāde mikotoksīnu noteikšanai Puer tējās
2019
Maģistra darba ietvaros tika izstrādāta inovatīva divdimensionālās šķidruma hromatogrāfijas metode tandēmā ar augstas izšķirtspējas nolidojuma laika masspektrometriju (2D-LC-TOF-HRMS) 70 “jauno” un reglamentēto mikotoksīnu noteikšanai Puer tēju matricā. Šis uzdevums tika izvirzīts ar mērķi palielināt nosakāmo mikotoksīnu skaitu, uzlabot metodes selektivitāti un novērst traucējošo matricas komponentu efektu, pielietojot savienojumu atdalīšanu ar 2D-LC sistēmas palīdzību. Metode tika validēta saskaņā ar Eiropas Savienības analīzes metodes vadlīnijām. Izstrādātā online-heart-cutting-2D-HPLC-HRMS metode tika pielietota 20 Latvijā komerciāli pieejamajiem Puer tēju paraugiem, veicot analizēto mik…