Search results for "405"
showing 10 items of 3208 documents
El pensamiento espontáneo docente sobre la ciencia y su enseñanza
2018
<span>En las dos últimas décadas la investigación en didáctica de las ciencias ha centrado su atención en el aprendizaje y, en particular, se ha caracterizado por haber estudiado en profundidad el conocimiento inicial de los estudiantes en muy diversos dominios de las ciencias. Desde hace pocos años el énfasis está derivado -y cada vez con mayor interés- hacia el estudio de la enseñanza y, en particular, hacia el de su principal artífice: el profesorado.</span>
Sostenibilidad y laboratorios escolares
2018
<span>Actualmente no es ninguna exageración afirmar que estamos viviendo una situación de verdadera emergencia planetaria, marcada por toda una serie de graves problemas estrechamente relacionados entre sí, tales como: superpoblación, contaminación, agotamiento de recursos naturales, cambio climático, pérdida de biodiversidad, lluvia ácida y destrucción de la capa de ozono. Dichos problemas, lejos de disminuir, son cada vez más intensos y extienden su impacto sobre todo el planeta. Así, en cuanto al calentamiento global, se afirma que la gravedad es tal, que si no se pone freno antes de una decena de años, después será ya demasiado tarde (Gore, 2007).</span>
La motivación de los estudiantes y la enseñanza de la Química. Una cuestión controvertida
2018
<span>El tema de la motivación de los estudiantes hacia el aprendizaje de cualquier materia científica constituye una seria preocupación para el profesorado. En primer lugar, porque los docentes constatan una falta general de interés de los alumnos hacia las disciplinas científicas como la Física y la Química. Esta percepción ha sido corroborada por los propios estudiantes en diferentes trabajos de investigación. En efecto, los propios estudiantes señalan como principales causantes de su actitud desfavorable, de su desinterés hacia la ciencia y su aprendizaje, a la enseñanza de una ciencia descontextualizada...</span>
Dificultades para la incorporación a la enseñanza de los hallazgos de la investigación e innovación en didáctica de las ciencias
2018
<span>La importancia social concedida, desde hace ya décadas, a la educación científica (Dewey 1916; Langevin, 1926) ha ido creciendo y ha experimentado, últimamente, un cambio cualitativo. En efecto, la tradicional importancia concedida a las inversiones en educación científica y tecnológica, para hacer posible el desarrollo futuro de un país, ha dejado paso al convencimiento de que la alfabetización científica de todos los ciudadanos y ciudadanas ha pasado a constituir una exigencia urgente, un requisito también para el desarrollo inmediato.</span>
Elucidating the Influence of the Activation Energy on Reaction Rates by Simulations Based on a Simple Particle Model
2020
An application for visualizing the dynamic properties of an equimolar binary mixture of isotropic reactive particles is presented. By introducing a user selectable choice for the activation energy, the application is useful to demonstrate qualitatively that the reaction rate depends on the above choice and on temperature. The application is based on a 2D realistic dynamic model where atoms move because of their thermal energies and the trajectories are determined by solving numerically Newton’s laws according to a Molecular Dynamics (MD) scheme. Collisions are monitored as time progresses, and every time the collision energy is larger than the selected activation energy, a reactive event oc…
A concise route to MK-4482 (EIDD-2801) from cytidine.
2020
A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine. The selective acylation and direct amination eliminate the need for protecting and activating groups and proceed in overall yield of 75%, a significant advancement over the reported yield of 17%. The step count is reduced from five transformations to two, and expensive uridine is replaced with the more available cytidine.
Electrochemical Fluorocyclization of N-Allylcarboxamides to 2-Oxazolines by Hypervalent Iodine Mediator
2018
A resource saving protocol for the synthesis of 5-fluoromethyl-2-oxazolines by using electrochemistry has been realized. Thereby, a hypervalent iodine species I(III) is generated by anodic oxidation in the presence of Et3N·5HF and mediates the cyclization of N-allylcarboxamide to 5-fluoromethyl-2-oxazoline. This method allows application to various substrates furnishing the 2-oxazolines with yields up to 68%. The protocol is easy to conduct under constant current conditions offering a sustainable alternative over conventional reagent-based pathways.
High-resolution rovibrational spectroscopy of c-C3H2+: The ν7 C–H antisymmetric stretching band
2020
Abstract The ν 7 antisymmetric C–H stretching fundamental of c- C 3 H 2 + has been characterized in a cryogenic 22-pole ion trap by a novel type of action spectroscopy, in which the rovibrational excitation of c- C 3 H 2 + is detected as a slowing down of the low-temperature reaction c- C 3 H 2 + + H2 → C 3 H 3 + + H. Ninety-one rovibrational transitions with partly resolved fine structure doublets were measured in high resolution. Supported by high-level quantum chemical calculations, spectroscopic parameters were determined by fitting the observed lines with an effective Hamiltonian for an asymmetric rotor in a doublet electronic ground state, X ˜ A 1 2 , yielding a band origin at 3113.6…
The substituent effect of π-electron delocalization in N-methylamino-nitropyridine derivatives: crystal structure and DFT calculations
2020
AbstractThe crystal and molecular structures of 3-(N-methylamino)-2-nitropyridine, 5-(N-methylamino)-2-nitropyridine and 2-(N-methylamino)-5-nitropyridine have been characterized by X-ray diffraction. To perform conformational analysis, the geometries of the compounds as well as their conformers and rotamers were optimized at the B3LYP/6-311++G(3df,3pd) level. The resulting data were used to analyze the π-electron delocalization effect in relation to the methylamino group rotation in ortho-, meta- and para-substitution positions. Quantitative aromaticity indices were calculated based on which we estimated the electronic structures of the analyzed compounds. The substituent effect of the met…
Unsymmetrical Iron P-NH-P' Catalysts for the Asymmetric Pressure Hydrogenation of Aryl Ketones.
2017
R.H.M. thanks NSERC Canada for a Discovery grant and the Canada Council for the Arts for a Killam Fellowship. This work was also made possible by the SCICOMP NMR facilities provided by the Canada Foundation for Innovation, project number 19119, and the Ontario Ministry of Research, Innovation and Science. The Deutscher Akademischer Austauschdienst (DAAD) is thanked for support for A.P. Calculations were performed using the facilities of SHARCNET and Scinet of Compute/Calcul Canada