Search results for "41"

A CONFIGURAÇÃO INOVADORA DO PRINCÍPIO DA BOA ADMINISTRAÇÃO ENTRE PRIVADOS E AUTORIDADES PÚBLICAS NA UNIÃO EUROPÉIA

2017

O direito a uma boa administração pública é um dos direitos fundamentais da pessoa, garantido pelo artigo 41 da Carta dos direitos fundamentais da União Europeia, que, em 2009, por força do Tratado de Lisboa, tornou-se juridicamente vinculante com o mesmo valor de fonte primária dos Tratados europeus. Ele é definido como o direito de cada pessoa (física e jurídica) de receber, por parte da autoridade pública, em relação às questões que se lhe refiram, um tratamento imparcial, equitativo e num prazo razoável. Inclui, também, os seguintes direitos de natureza procedimental: a ser ouvida, antes de, a seu respeito, ser tomada qualquer medida individual que a afete desfavoravelmente; a ter acess…

Observer-based stabilization of spacecraft rendezvous with variable sampling and sensor nonlinearity

2013

Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://dx.doi.org/10.1155/2013/902452 Open Access This paper addresses the observer-based control problem of spacecraft rendezvous with nonuniform sampling period. The relative dynamic model is based on the classical Clohessy-Wiltshire equation, and sensor nonlinearity and sampling are considered together in a unified framework. The purpose of this paper is to perform an observer-based controller synthesis by using sampled and saturated output measurements, such that the resulting closed-loop system is exponentially stable. A time-dependent Lyapunov functional is devel…

Perceived barriers in the outdoor environment and development of walking difficulties in older people

2012

SIR—Older people with mobility limitations often report more barriers in their outdoor environment than people with intact mobility [1]. However, it is uncertain whether older people perceive their environment as problematic because of their mobility limitations or whether the environmental barriers precede incident mobility limitation, as most studies have been limited to cross-sectional analyses [2–5]. Only a few longitudinal studies have shown that barriers in the outdoor environment, such as poor street conditions, poor lighting and heavy traffic, increase the risk for overall functional loss [6, 7] and decrease physical activity participation [8]. More knowledge is needed about the cha…

Older rehabilitees’ life-course agency in Finnish gerontological rehabilitation

2015

Aims: This study investigates gerontological rehabilitation sessions of Finnish rehabilitees in the framework of life-course agency from the perspectives of temporal orientation and agency. Methods: The research data were obtained by non-participatory observation in 11 individual goal-setting sessions between 11 rehabilitees and their personal counsellors. The data were analysed in accordance with data-driven, qualitative content and narrative analysis, with an emphasis on the life-course agency approach. Results: Four temporal orientations of older rehabilitees were identified in the rehabilitation sessions: (i) timeless, (ii) past, (iii) present, and (iv) life course. For each temporal or…

Direct Analysis of Psilocin and Muscimol in Urine Samples Using Single Drop Microextraction Technique In-Line with Capillary Electrophoresis

2020

The fully automated system of single drop microextraction coupled with capillary electrophoresis (SDME-CE) was developed for in-line preconcentration and determination of muscimol (MUS) and psilocin (PSC) from urine samples. Those two analytes are characteristic active metabolites of Amanita and Psilocybe mushrooms, evoking visual and auditory hallucinations. Study analytes were selectively extracted from the donor phase (urine samples, pH 4) into the organic phase (a drop of octanol layer), and re-extracted to the acidic acceptor (background electrolyte, BGE), consisting of 25 mM phosphate buffer (pH 3). The optimized conditions for the extraction procedure of a 200 &micro

Tandem cross enyne metathesis (CEYM)–intramolecular Diels–Alder reaction (IMDAR). An easy entry to linear bicyclic scaffolds

2015

A new tandem cross enyne metathesis (CEYM)–intramolecular Diels–Alder reaction (IMDAR) has been carried out. It involves conjugated ketones, esters or amides bearing a remote olefin and aromatic alkynes as the starting materials. The overall process enables the preparation of a small family of linear bicyclic scaffolds in a very simple manner with moderate to good levels of diastereoselectivity. This methodology constitutes one of the few examples that employ olefins differently than ethylene in tandem CEYM–IMDAR protocols.

Direct oxidation of isobutane to methacrolein over V-MCM-41 catalysts

2004

High vanadium content mesoporous vanado-silicates with MCM-41-like structure, obtained by the atrane route, catalyse the direct oxidation of isobutane to methacrolein with 30% selectivity, and a total dehydrogenation (olefin plus methacrolein) selectivity up to 74%.

Mujeres, trabajo y asociación rural

2019

Impact of dietary intervention on serum neurofilament light chain in multiple sclerosis

2021

Background and ObjectivesAdapted ketogenic diet (AKD) and caloric restriction (CR) have been suggested as alternative therapeutic strategies for multiple sclerosis (MS), but information on their impact on neuroaxonal damage is lacking. Thus, we explored the impact of diets on serum neurofilament light chain (sNfL) levels in patients with relapsing-remitting MS.MethodsWe retrospectively evaluated a prospective randomized controlled trial of 60 patients with MS who were on a common diet or ketogenic diet or fasting. We examined sNfL levels of 40 participants at baseline and at the end of the study after 6 months using single molecule array assay.ResultssNfL levels were investigated in 9 contr…

Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS

2020

ObjectiveWe applied longitudinal 3T MRI and advanced computational models in 2 independent cohorts of patients with early MS to investigate how white matter (WM) lesion distribution and cortical atrophy topographically interrelate and affect functional disability.MethodsClinical disability was measured using the Expanded Disability Status Scale Score at baseline and at 1-year follow-up in a cohort of 119 patients with early relapsing-remitting MS and in a replication cohort of 81 patients. Covarying patterns of cortical atrophy and baseline lesion distribution were extracted by parallel independent component analysis. Predictive power of covarying patterns for disability progression was tes…