Search results for "41"
showing 10 items of 3365 documents
Accelerated Changes of Environmental Conditions on the Tibetan Plateau Caused by Climate Change
2011
Abstract Variations of land surface parameters over the Tibetan Plateau have great importance on local energy and water cycles, the Asian monsoon, and climate change studies. In this paper, the NOAA/NASA Pathfinder Advanced Very High Resolution Radiometer (AVHRR) Land (PAL) dataset is used to retrieve the land surface temperature (LST), the normalized difference vegetation index (NDVI), and albedo, from 1982 to 2000. Simultaneously, meteorological parameters and land surface heat fluxes are acquired from the 40-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40) dataset and the Global Land Data Assimilation System (GLDAS), respectively. Results show that from …
Hsp70 and Its Molecular Role in Nervous System Diseases
2011
Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerative disease, epilepsy, and trauma. The overexpression of one HSP in particular, Hsp70, serves a protective role in several different models of nervous system injury, but has also been linked to a deleterious role in some diseases. Hsp70 functions as a chaperone and protects neurons from protein aggregation and toxicity (Parkinson disease, Alzheimer disease, polyglutamine diseases, and amyotrophic lateral sclerosis), protects cells from apoptosis (Parkinson disease), is a stress marker (temporal lobe epilepsy), protects cells from inflammation (cerebral ischemic injury), has an adjuvant role i…
A Theoretical Study of the Relationship between the Electrophilicity ω Index and Hammett Constant σp in [3+2] Cycloaddition Reactions of Aryl Azide/A…
2016
The relationship between the electrophilicity ω index and the Hammett constant σp has been studied for the [2+3] cycloaddition reactions of a series of para-substituted phenyl azides towards para-substituted phenyl alkynes. The electrophilicity ω index—a reactivity density functional theory (DFT) descriptor evaluated at the ground state of the molecules—shows a good linear relationship with the Hammett substituent constants σp. The theoretical scale of reactivity correctly explains the electrophilic activation/deactivation effects promoted by electron-withdrawing and electron-releasing substituents in both azide and alkyne components.
Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
2013
New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, 1 H-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG).
The Black-Litterman model
2013
Masteroppgave i økonomi og administrasjon - Universitetet i Agder 2013 The Markowitz model has two problematic tendencies; unintuitive portfolios and portfolios with high transaction costs. The Black-Litterman model was made as an improvement of the Markowitz model. It uses a Bayesian approach to combine the views of the investor with the equilibrium portfolio. The main purpose of the model is to create intuitive portfolios and limit the transaction costs. With the computer power available today, the implementation of mathematical models are an important issue. Using the programming language R, I will in this thesis look at possible ways of implementing the Black-Litterman model. Todays inv…
The performance of Value-at-Risk models on the OBX index
2013
Masteroppgave i økonomi og administrasjon - Universitetet i Agder 2013 The measuring of risk has become one of the main fields in finance during the last two decades. Value-at-Risk (VaR) has become one of the most important risk measures and is widely used for numerous applications. This thesis compares different approaches to VaR based on traditional methods such as Historical Simulation, Moving Average and Exponentially Weighted Moving Average as well as advanced approaches based on GARCH models. Comparison is done on the OBX index return data, which is the main benchmark index on the Oslo Stock Exchange. The performance of the different VaR models is evaluated with out of sample backtest…
Cross cultural influences on female apparel selection : a comparison of Norway and Pakistan
2012
Masteroppgave i økonomi og administrasjon - Universitetet i Agder 2012 The objective of this study was to investigate and compare the impacts rendered on the consumer choices and selection behavior cross culturally, specifically for the casual wear among well educated female consumers of Norway and Pakistan. The criteria used were based on the several cultural traits recognized as well as clothing values. The clothing values are basically the meaning or the types of associations a consumer form with the selective clothes. Clothing is a very integral part of one’s life. There is a small poem by William Allen Butler, called "Nothing to Wear"; It goes like this: Dresses for breakfasts, and din…
Exploration of stationary time-series’ network properties : Visibility-and Horizontal visibility graph of Gaussian white noise, AR (1), MA (1) and AR…
2019
Master's thesis Business Administration BE501 - University of Agder 2019 We haverecordedthe network properties ofstochastic processes’whitenoise,푀퐴(1), 퐴푅(1)and 퐴푅푀퐴(1,1)bymeansof visibility-and horizontal visibility algorithms. The sample series of the stochastic processeswere artificially generated and used in simulationswith multiple repetitions. We examined six global network properties:mean degree, normalized degree centrality, degree distribution, transitivity, assortativity and average geodesic pathtodiscover how theyreflect the structure of the series. These properties were also used to disclose change in behavior due to variation in the series length.Our contribution to the literat…
HBV kapsīdu savākšanās inhibīcija ar mazmolekulāriem savienojumiem
2016
Hepatīta B vīrusa (HBV) infekcija hroniskā formā ir viena no bīstamākajām mūsdienu saslimšanām, tāpēc aktīvi tiek meklētas iedarbīgas zāles infekcijas ārstēšanai. Ar mērķi atrast efektīvu un netoksisku HBV nukleokapsīdu inhibitoru, ir veikta plaši pētīta Bay-41-4109 inhibitora un tā analogu pārbaude zīdītāju šūnās. Šajā darbā HBV kapsīdas proteīna (HBc) sintēze BHK-21 šūnās nodrošināta, izmantojot rekombinantu alfavīrusa replikonu. Ir pārbaudīta Bay-41-4109 un tā analogu citotoksicitāte šūnās. Izmantojot natīvās agarozes un SDS-PAA gēla elektroforēzes un imunoblota metodes tika salīdzināta inhibitoru ietekme uz HBc proteīna ekspresiju un nukleokapsīdu veidošanos šūnās. Atrasts, ka viens no …