Search results for "41"
showing 10 items of 3365 documents
Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
2021
To date, computational approaches have been recognized as a key component in drug design and discovery workflows. Developed to help researchers save time and reduce costs, several computational tools have been developed and implemented in the last twenty years. At present, they are routinely used to identify a therapeutic target, understand ligand–protein and protein–protein interactions, and identify orthosteric and allosteric binding sites, but their primary use remains the identification of hits through ligand-based and structure-based virtual screening and the optimization of lead compounds, followed by the estimation of the binding free energy. The repurposing of an old drug for the tr…
Everyday Appropriations of Information Technology: A Study of Creative Uses of Digital Cameras
2011
Repurposive appropriation is a creative everyday act in which a user invents a novel use for information technology (IT) and adopts it. This study is the first to address its prevalence and predictability in the consumer IT context. In all, 2,379 respondents filled in an online questionnaire on creative uses of digital cameras, such as using them as scanners, periscopes, and storage media. The data reveal that such creative uses are adopted by about half of the users, on average, across different demographic backgrounds. Discovery of a creative use on one's own is slightly more common than is learning it from others. Most users discover the creative uses either completely on their own or wh…
On the Coincidence of the Feedback Nash and Stackelberg Equilibria in Economic Applications of Differential Games
2002
In this paper the scope of the applicability of the Stackelberg equilibrium concept in differential games is investigated. Firstly, conditions for obtaining the coincidence between the Stackelberg and Nash equilibria are defined in terms of the instantaneous pay-off function and the state equation of the game. Secondly, it is showed that for a class of differential games with state-interdependence both equilibria are identical independently of the player being the leader of the game. A survey of different economic models shows that this coincidence is going to occur for a good number of economic applications of differential games. This result appears because of the continuous-time setting i…
Finite-Time Distributed Energy-to-Peak Control for Uncertain Multiagent Systems
2014
Published version of an article in the journal: Abstract and Applied Analysis. Also available from the publisher at: http://dx.doi.org/10.1155/2014/260201 Open Access This paper investigates the finite-time distributed L2-L∞ consensus control problem of multiagent systems with parameter uncertainties. The relative states of neighboring agents are used to construct the control law and some agents know their own states. By substituting the control input into multiagent systems, an augmented closed-loop system is obtained. Then, we analyze its finite-time boundedness (FTB) and finite-time L2-L∞ performance. A sufficient condition for the existence of the designed controller is given with the f…
Mathematical Learning Opportunities in Kindergarten through the Use of Digital Tools: Affordances and Constraints
2013
Accepted version of an article in the journal: Nordic Journal of Digital Literacy. Also available from the publisher at: http://www.idunn.no/ts/dk/2013/03/mathematical_learning_opportunities_in_kindergarten_through This study aims at scrutinising the mathematical learning opportunities of children engaging with digital tools and the emerging affordances and constraints faced in such settings. By adopting a sociocultural perspective on learning and development, the multimodal analysis of the adult-child interaction shows that the children are participants in processes of appropriating the mathematical concepts of sorting and counting. Affordances are taken advantage of by the adults and cons…
Perspectives and reflections on teaching linear algebra
2020
Abstract This paper presents ‘expert opinions’ on what should be taught in a first-year linear algebra course at university; the aim is to gain a generic picture and general guiding principles for such a course. Drawing on a Delphi method, 14 university professors—called ‘experts’ in this study—addressed the following questions: What should be on a first-year linear algebra undergraduate course for engineering and/or mathematics students? How could such courses be taught? What tools (if any) are essential to these two groups of students? The results of the investigation, these experts’ opinions, mainly concern what should be in a linear algebra course (e.g. problem-solving and applications)…
Design and Investigation of a Touch Gesture for Dividing in a Virtual Manipulative Model for Equation-solving
2020
AbstractPhysical models for equation solving typically lack feedback regarding their appropriate use. Such feedback is possible in virtual environments and could be implemented in hybrid models. Based on an epistemological analysis, this article presents a touch gesture as a way for users to signal they want to divide both sides of an equation and a design for feedback on the use of this so-called ‘division gesture’. The design is investigated by contrasting a case study, in which students used an app with the division gesture, with a preparatory study where students had to perform corresponding actions on physical manipulatives. This investigation revealed insight into feedback functions, …
New Anti-Neoplastics Obtained by a Molecular Connectivity Method
2000
Molecular Connectivity is a method, which allows to discriminate different pharmacological activities on the basics of numeric parameters of the molecules in study, related with specific and exclusive indexes. In the present study, we propose two potentially anti-neoplasic compounds: tricromil and zomepirac, by analyzing more than a hundred different chemicals.
Multiword Units in Machine Translation and Translation Technology
2018
This article describes a new word alignment gold standard for German nominal compounds and their multiword translation equivalents in English, French, Italian, and Spanish. The gold standard contains alignments for each of the ten language pairs, resulting in a total of 8,229 bidirectional alignments. It covers 362 occurrences of 137 different German compounds randomly selected from the corpus of European Parliament plenary sessions, sampled according to the criteria of frequency and morphological complexity. The standard serves for the evaluation and optimisation of automatic word alignments in the context of spotting translations of German compounds. The study also shows that in this text…
Study on Support Vector Machine-Based Fault Detection in Tennessee Eastman Process
2014
Published version of an article in the journal: Abstract and Applied Analysis. Also available from the publisher at: http://dx.doi.org/10.1155/2014/836895 Open Access This paper investigates the proficiency of support vector machine (SVM) using datasets generated by Tennessee Eastman process simulation for fault detection. Due to its excellent performance in generalization, the classification performance of SVM is satisfactory. SVM algorithm combined with kernel function has the nonlinear attribute and can better handle the case where samples and attributes are massive. In addition, with forehand optimizing the parameters using the cross-validation technique, SVM can produce high accuracy i…