Search results for "47"

Flower lose, a cell fitness marker, predicts COVID‐19 prognosis

2021

Abstract Risk stratification of COVID‐19 patients is essential for pandemic management. Changes in the cell fitness marker, hFwe‐Lose, can precede the host immune response to infection, potentially making such a biomarker an earlier triage tool. Here, we evaluate whether hFwe‐Lose gene expression can outperform conventional methods in predicting outcomes (e.g., death and hospitalization) in COVID‐19 patients. We performed a post‐mortem examination of infected lung tissue in deceased COVID‐19 patients to determine hFwe‐Lose’s biological role in acute lung injury. We then performed an observational study (n = 283) to evaluate whether hFwe‐Lose expression (in nasopharyngeal samples) could accu…

Cancer Stem Cell Biomarkers Predictive of Radiotherapy Response in Rectal Cancer: A Systematic Review

2021

Background: Rectal cancer (RC) is one of the most commonly diagnosed and particularly challenging tumours to treat due to its location in the pelvis and close proximity to critical genitourinary organs. Radiotherapy (RT) is recognised as a key component of therapeutic strategy to treat RC, promoting the downsizing and downstaging of large RCs in neoadjuvant settings, although its therapeutic effect is limited due to radioresistance. Evidence from experimental and clinical studies indicates that the likelihood of achieving local tumour control by RT depends on the complete eradication of cancer stem cells (CSC), a minority subset of tumour cells with stemness properties. Methods: A systemati…

Head and Neck Lymphomas in HIV Patients: a Clinical Perspective

2017

Introduction Because of the many HIV-related malignancies, the diagnosis and treatment of lymphoma in patients infected with human immunodeficiency virus are challenging. Objective Here, we review current knowledge of the pathogenesis, epidemiology, symptomatology, diagnosis, and treatment of head and neck lymphomas in HIV patients from a clinical perspective. Data Synthesis Although Hodgkin's lymphoma is not an AIDS-defining neoplasm, its prevalence is ten times higher in HIV patients than in the general population. NHL is the second most common malignancy in HIV patients, after Kaposi's sarcoma. In this group of patients, NHL is characterized by rapid progression, frequent extranodal inv…

Analysis of the road traffic management system in the neural network development perspective

2019

The research goal of the paper is to present the issues connected with road traffic management systems and to illustrate a management system that uses Intelligent Transportation Systems and neural networks. The use of Intelligent Transportation Systems (ITS) is a method of improving the conditions of communications, making it independent from the development of communications infrastructure. The attributes of neural networks are focused on solving the problems of optimisation, which involve the development of optimal strategies for traffic management. The proposed road traffic management system that uses ITS and neural networks can be applied in prediction of the conditions of communication…

Ultraviolet-induced paramagnetic centers and absorption changes in singlemode Ge-doped optical fibers

2009

We investigated the laser-energy-density dependence of absorption changes and paramagnetic centers induced by a cw Ar+ laser operating at 5.1 eV, in both unloaded and H-2-loaded single mode Ge-doped optical fibers. The induced absorption is measured in the blue and near ultraviolet spectral range by using the 3.1 eV photoluminescence, ascribed to Ge lone pair center (GLPC), as an in situ probe source. We find that the Ge (1) center (GeO4-) is induced upon UV exposure by electron trapping on GeO4 precursors, where the free electrons are most likely produced by ionization of GLPC. Ge (1) is responsible of optical transmission loss of the fiber in the investigated range. Hydrogen loading stron…

Banki-Michell Optimal Design by Computational Fluid Dynamics Testing and Hydrodynamic Analysis

2013

In hydropower, the exploitation of small power sources requires the use of small turbines that combine efficiency and economy. Banki-Michell turbines represent a possible choice for their simplicity and for their good efficiency under variable load conditions. Several experimental and numerical tests have already been designed for examining the best geometry and optimal design of cross-flow type machines, but a theoretical framework for a sequential design of the turbine parameters, taking full advantage of recently expanded computational capabilities, is still missing. To this aim, after a review of the available criteria for Banki-Michell parameter design, a novel two-step procedure is de…

Regularity of sets under a reformulation in a product space of reduced dimension

2023

Different notions on regularity of sets and of collection of sets play an important role in the analysis of the convergence of projection algorithms in nonconvex scenarios. While some projection algorithms can be applied to feasibility problems defined by finitely many sets, some other require the use of a product space reformulation to construct equivalent problems with two sets. In this work we analyze how some regularity properties are preserved under a reformulation in a product space of reduced dimension. This allows us to establish local linear convergence of parallel projection methods which are constructed through this reformulation.

Oracion a Santa Catarina de Sena, particular Abogada de moribundos, para lograr en la hora de la muerte el recibir los santos Sacramentos.

Grav. xil. enmarcat de "S. Catarina de Sena" El full orlat

Arquitectura renacentista "inacabada" de Jerónimo Quijano y su integración en determinados templos de origen gòtico

2014

Jerónimo Quijano fue un arquitecto español que destacó durante la etapa del Renacimiento Pleno en España en el tercio central del siglo XVI. Los edificios seleccionados principalmente son: iglesia de Santiago de Orihuela –Alicante– e iglesia de Santa María del Salvador de Chinchilla –Albacete–. En ambos se construyó una nueva cabecera renacentista e integrada en una nave gótica preexistente y en el caso de haber sido “acabadas” íntegramente con el criterio del maestro serían sin duda ejemplos claves del Renacimiento español. En Orihuela se percibe la necesidad de “descubrir” visualmente el magnífico arco de triunfo romano que hace de portada de la nueva cabecera renacentista, sugiriendo así…

Brief an Garlieb H. Merkel

1799

Ms. 930a, Nr. 8, Bl. 22r-23v Böttiger, Karl August. Brief an Garlieb H. Merkel, Weimar, d[en] 13. November 1797 Autora rokraksts / Autograph, vācu, angļu un latīņu val. / Deutsch, Englisch und Latein [4] lpp. / S. Attēlu numuri / Bildnummern: 930a-008-1 – 930a-008-4 Der Verfasser nennt in diesem inhaltsreichen Brief zahlreiche Namen und hält nicht nur die Verbindung mit Merkel, die aus dessen erstem Aufenthalt in Weimar resultierte, aufrecht, sondern gibt ihm weitere Hinweise und Empfehlung für seinen weiteren Aufenthalt in Dänemark. So rät er zur Übersetzung dreier Romane aus dem Englischen, darunter Jane Wests „A gossip's story“ (London 1796). Ferner bittet der Verfasser Merkel um Gefälli…