Search results for "5-Triazine"

showing 10 items of 79 documents

1,3,5-Triazines: A promising scaffold for anticancer drugs development

2017

This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the structure-activity relationship and, whenever reported, the possible mechanism of action of 1,3,5-triazine derivatives as well as of their hetero-fused compounds. Many 1,3,5-triazine derivatives, both uncondensed and hetero-fused, have shown remarkable antitumor activities and some of them reached clinical development.

0301 basic medicineModels MolecularScaffold31Disubstituted 135-triazineTrisubstituted 135-triazineAntineoplastic AgentsChemistry Techniques Synthetic01 natural sciences03 medical and health sciencesStructure-Activity RelationshipNeoplasmsDrug DiscoverymedicineAnimalsHumans5-TriazinesTrisubstituted 1Disubstituted 1Antitumor activityPharmacologyHeterofused 135-triazine010405 organic chemistryChemistryTriazinesNitrogen heterocyclesDrug Discovery3003 Pharmaceutical ScienceOrganic ChemistryGeneral MedicineHeterofused 1Combinatorial chemistry135-Triazine0104 chemical sciences030104 developmental biologyNitrogen heterocycleMechanism of action1; 3; 5-Triazines; Antitumor activity; Disubstituted 1; 3; 5-triazines; Heterofused 1; 3; 5-triazines; Nitrogen heterocycles; Trisubstituted 1; 3; 5-triazines; Pharmacology; Drug Discovery3003 Pharmaceutical Science; Organic Chemistrymedicine.symptomAntitumor activity
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Metal-free regioselective C–C bond cleavage in 1,3,5-triazine derivatives of β-diketones

2014

Metal-free regioselective activation of a carbon–carbon bond in 1,3,5-triazine derivatives of β-diketones is easily achieved, in the absence of a catalyst, with the assistance of intramolecular hydrogen bonding.

ChemistryHydrogen bondRegioselectivityGeneral ChemistryCatalysisCatalysischemistry.chemical_compound135-TriazineMetal freeIntramolecular forcePolymer chemistryMaterials ChemistryOrganic chemistryta116Bond cleavageNew J. Chem.
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Synthesis, structure and magnetic properties of the one-dimensional chain compound {K[Fe(1,3,5-triazine-2,4,6-tricarboxylate)(H2O)2]·2H2O}∞

2002

The one-dimensional chain compound {[Fe(1,3,5-triazine-2,4,6-tricarboxylate)(H2O)2]}n−n was obtained from a reaction of 1,3,5-triazine-2,4,6-tricarboxylate with Fe(II) in water at room temperature. The high-spin Fe(II) centers adopt a pentagonal bipyramid geometry with unusual ligand binding modes. Magnetic measurements revealed weak magnetic interactions between paramagnetic centers; these were modeled with both axial and rhombic distortions.

Paramagnetismchemistry.chemical_compoundCrystallographyMagnetic measurementsPentagonal bipyramidal molecular geometryChain (algebraic topology)135-TriazineChemistryCompound KGeneral ChemistryTricarboxylateJournal of the Chemical Society, Dalton Transactions
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CCDC 1583576: Experimental Crystal Structure Determination

2018

Related Article: David Straßburger, Natascha Stergiou, Moritz Urschbach, Hajime Yurugi, Daniel Spitzer, Dieter Schollmeyer, Edgar Schmitt, Pol Besenius|2018|ChemBioChem|19|912|doi:10.1002/cbic.201800114

Space GroupCrystallography22'2''-(135-triazine-246-triyltrisulfanediyl)triacetic acidCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1492552: Experimental Crystal Structure Determination

2018

Related Article: T.E. Gorelik, J. van de Streek, H. Meier, L. Andernach, T. Opatz|2018|Acta Crystallogr.,Sect.B:Struct.Sci.,Cryst.Eng. and Mat.|74|287|doi:10.1107/S2052520618006686

Space GroupCrystallography44'4''-[135-triazine-246-triyltris(ethene-21-diyl)]tris(NN-dimethylaniline)Crystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 821714: Experimental Crystal Structure Determination

2012

Related Article: K.Raatikainen, K.Rissanen|2011|CrystEngComm|13|6972|doi:10.1039/c1ce05447c

Space GroupCrystallographyCrystal SystemCrystal Structure135-triazine bis(1-iodopyrrolidine-25-dione)Cell ParametersExperimental 3D Coordinates
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CCDC 105199: Experimental Crystal Structure Determination

1999

Related Article: G.E.Herberich, E.Barday, A.Fischer|1998|J.Organomet.Chem.|567|127|doi:10.1016/S0022-328X(98)00674-3

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(eta^5^-1-(bis(NN-Dimethylamino)boryl)indene)-(NN'N''-trimethyl-hexahydro-135-triazine-NN'N'')-lithiumExperimental 3D Coordinates
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CCDC 149748: Experimental Crystal Structure Determination

2001

Related Article: C.Schmidt, E.F.Paulus, V.Bohmer, W.Vogt|2001|New J.Chem.|25|374|doi:10.1039/b010210p

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters135-tris((R)-1-Indyl)-hexahydro-135-triazineExperimental 3D Coordinates
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CCDC 1894806: Experimental Crystal Structure Determination

2019

Related Article: Natalie Tober, Thorsten Rieth, Matthias Lehmann, Heiner Detert, |2019|Chem.-Eur.J.|25|15295|doi:10.1002/chem.201902975

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters246-tris(5-[4-propoxyphenyl]-134-oxadiazol-2-yl)-135-triazine toluene solvateExperimental 3D Coordinates
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CCDC 1986850: Experimental Crystal Structure Determination

2020

Related Article: Beatriz Feringán, Jesús Cerdá, Beatriz Diosdado, Juan Aragó, Enrique Ortí, Raquel Giménez, Teresa Sierra|2020|Chem.-Eur.J.|26|15313|doi:10.1002/chem.202001271

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters24-bis[1-(4-butoxyphenyl)-1H-123-triazol-4-yl]-6-[1-(4-butoxyphenyl)-1H-123-triazol-4-yl]-135-triazine unknown solvate dihydrateExperimental 3D Coordinates
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