Search results for "54"
showing 10 items of 2200 documents
Les poisons du XIXe et leur traduction à l’espagnol : Mateu Orfila et son Traité des poisons (1814-1815)
2019
Dans ce travail, on étudie une des œuvres pionnières de référence en toxicologie du XIXe siècle : Traité des poisons, publiée par Mathieu Orfila entre 1814 et1815 à Paris, traduite en espagnol par le Dr. Mariano de Larra y Langelot en 1819, et éditée à Madrid. Larra se vante, dans l'introduction, que sa traduction a été révisée par Orfila lui-même, détail qui n’apparaît pas dans les traductions en allemand, anglais ou italien. Nous présenterons les événements historiques qui ont accompagné cette première traduction, ainsi que les raisons qui ont conduit Mariano de Larra, père du célèbre écrivain romantique Mariano José de Larra, à traduire ce travail après avoir été exilé en France pendant …
Le graphic novel italien Peppino Impastato un giullare contro la mafia et sa traduction française
2018
Eddie Campbell dans son Graphic Novel Manifesto définit ce nouvel art «a movement rather than a form», un courant d’auteurs dont le but est d’élever la bande dessinée à des niveaux plus ambitieux, d’autant plus que l’objet de leurs œuvres dérive de l’histoire passée où récente d’un Pays. Le critique et essayiste italien Goffredo Fofi considère le graphic novel la forme expressive la plus vitale au monde aujourd’hui au même niveau que les documentaires cinématographiques. Traduire un graphic novel comporte tous les défis de la traduction d’une bande dessinée et d’un récit avec en plus, dans le cas de Peppino Impastato, la difficulté linguistique due à l’emploi de formes dialectales du sicili…
Extracellular Vesicle microRNAs Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma
2020
Osteolytic bone disease is the major complication associated with the progression of multiple myeloma (MM). Recently, extracellular vesicles (EVs) have emerged as mediators of MM-associated bone disease by inhibiting the osteogenic differentiation of human mesenchymal stem cells (hMSCs). Here, we investigated a correlation between the EV-mediated osteogenic inhibition and MM vesicle content, focusing on miRNAs. By the use of a MicroRNA Card, we identified a pool of miRNAs, highly expressed in EVs, from MM cell line (MM1.S EVs), expression of which was confirmed in EVs from bone marrow (BM) plasma of patients affected by smoldering myeloma (SMM) and MM. Notably,we found that miR-129-5p, whic…
Transparency in Spanish credit institutions
2012
Codes of conduct have become perhaps the most frequently used tool in the management of corporate social responsibility. This research aims to determine the wa y in which Credit Institutions perceive tr ansparency and to see how this influ- ences the application of codes of ethics. The fieldwork was conducted by means of a survey that was answered by 57 Spanish Credit Institutions. The code of ethics has high significance and good positive correlation when reporting on the delivery of products and services , using criteria of social responsibility
Divergent Patterns and Trends in Breast Cancer Incidence, Mortality and Survival Among Older Women in Germany and the United States
2020
Background: Breast cancer treatment has changed tremendously over the last decades. In addition, the use of mammography screening for early detection has increased strongly. To evaluate the impact of these developments, long-term trends in incidence, mortality, stage distribution and survival were investigated for Germany and the United States (US). Methods: Using population-based cancer registry data, long-term incidence and mortality trends (1975&ndash
Semi-natural habitats in boreal Europe: a rise of a social-ecological research agenda
2021
The European continent contains substantial areas of semi-natural habitats, mostly grasslands, which are among the most endangered habitats in Europe. Their continued existence depends on some form of human activity, for either production or conservation purposes, or both. We examined the share of semi-natural grasslands within the general grassland areas in boreal Europe. We reviewed research literature across the region to compile evidence on semi-natural grasslands and other semi-natural habitats, such as wooded pastures, in respect to a range of topics such as ecology, land-use change, socioeconomics, and production. We also explored drivers of the research agenda and outlined future re…
Randomized Trial : D-Glyceric Acid Activates Mitochondrial Metabolism in 50–60-Year-Old Healthy Humans
2021
Background: Based on earlier studies, natural metabolite D-glyceric acid (DGA) does not seem to play any role in whole-body metabolism. Nevertheless, one ethanol oxidation-related rat study with controversial results raised our interest. According to preparatory studies for the regulatory approval of DGA, some highly conserved mechanism seems to subtly activate the cellular energy metabolism. Therefore, the present 25-days double-blind human study with placebo control was initiated. Purpose: The main target in the present study with 27 healthy 50–60-year-old human volunteers was to find out whether an “acute” 4-days and a longer 21-days exogenous DGA regimen caused moderate activation of th…
Extracellular Vesicles as Shuttles of Tumor Biomarkers and Anti-Tumor Drugs
2014
Extracellular vesicles (EV) include vesicles released by either normal or tumor cells. EV may exceed the nanometric scale (microvesicles), or to be within the nanoscale, also called exosomes. Thus, it appears that only exosomes and larger vesicles may have the size for potential applications in nanomedicine, in either disease diagnosis or therapy. This is of particular interest for research in cancer, also because the vast majority of existing data on EV are coming from pre-clinical and clinical oncology. We know that the microenvironmental features of cancer may favor cell-to-cell paracrine communication through EV, but EV have been purified, characterized, and quantified from plasma of tu…
Fenomenografia ja variaatioteoria aikuiskasvatustieteen tutkimuksessa
2016
Aikuiskasvatuksen tutkimusmenetelmiä: Aikuiskasvatuksen asiantuntijat esittelevät aikuiskasvatustieteen tutkimusmenetelmiä ja näkökulmia tutkimukseen.
Do Older Employees Suffer More from Work Intensification and Other Intensified Job Demands? Evidence from Upper White-Collar Workers
2019
Background: Working life today is characterized by acceleration and intensification due to social, and particularly technological, acceleration affecting the whole of society. These phenomena also affect working life by intensifying job demands, possibly imposing new job stressors on the workforce. At the same time workforce is aging, raising a question how older employees manage to cope with these work life changes. Methods: This study examined intensified job demands and their effects on occupational well-being from the age perspective utilizing Finnish survey data from upper white-collar workers (N = 2,200). Data was analyzed using multivariate analysis of covariance and hierarchical reg…