Search results for "58"
showing 10 items of 2229 documents
Bovine paramphistomosis in Galicia (Spain): Prevalence, intensity, aetiology and geospatial distribution of the infection
2013
12 páginas, 5 figuras, 4 tablas.
Gozos de S. Vicente de Paul para las Hijas de la Caridad
Il·lustració del sant situada entre el goig Text del goig a tres col. separades per dobles filets i, també, a línia tirada
PML nuclear body-residing proteins sequentially associate with HPV genome after infectious nuclear delivery.
2019
Subnuclear promyelocytic leukemia (PML) nuclear bodies (NBs) are targeted by many DNA viruses after nuclear delivery. PML protein is essential for formation of PML NBs. Sp100 and Small Ubiquitin-Like Modifier (SUMO) are also permanently residing within PML NBs. Often, large DNA viruses disassemble and reorganize PML NBs to counteract their intrinsic antiviral activity and support establishment of infection. However, human papillomavirus (HPV) requires PML protein to retain incoming viral DNA in the nucleus for subsequent efficient transcription. In contrast, Sp100 was identified as a restriction factor for HPV. These findings suggested that PML NBs are important regulators of early stages o…
Convolutional architectures for virtual screening
2020
Abstract Background A Virtual Screening algorithm has to adapt to the different stages of this process. Early screening needs to ensure that all bioactive compounds are ranked in the first positions despite of the number of false positives, while a second screening round is aimed at increasing the prediction accuracy. Results A novel CNN architecture is presented to this aim, which predicts bioactivity of candidate compounds on CDK1 using a combination of molecular fingerprints as their vector representation, and has been trained suitably to achieve good results as regards both enrichment factor and accuracy in different screening modes (98.55% accuracy in active-only selection, and 98.88% …
Effects of a structured educational intervention in moderate-to-severe elderly asthmatic subjects.
2019
Background: Adherence to inhaled drugs is linked to patients’ satisfaction with their device, and an incorrect use can negatively affect the outcomes of asthma treatment. We speculated that this is particularly true in elderly asthmatic subjects. Aim: We performed a national pre-post interventional multicentre study, enrolling moderate-to-severe asthmatic subjects aged ≥65 years treated with fixed inhaled combination drugs by dry powder inhaler (DPI) or pressurized metered dose inhaler (pMDI). Adherence and critical errors were evaluated by means of validated questionnaires at first visit (V1) and after 3–6 months (V2). At V1, subjects underwent intensive training on the correct use of the…
Waiting-time and quality of care deserved to patients with early stage hepatocellular carcinoma undergoing RFA treatment
2017
Water stable isotope data set in temperate, lowland catchment, two years of monthly observations, River Salaca, Latvia
2020
Highlights • Two years of monthly water stable isotope ratios from temperate lowland catchment. • Hourly water table, temperature and electrical conductivity monitoring. • Distinct isotope ratios for raised bog, groundwater and rivers.
FluDetWeb: an interactive web-based system for the early detection of the onset of influenza epidemics
2009
Abstract Background The early identification of influenza outbreaks has became a priority in public health practice. A large variety of statistical algorithms for the automated monitoring of influenza surveillance have been proposed, but most of them require not only a lot of computational effort but also operation of sometimes not-so-friendly software. Results In this paper, we introduce FluDetWeb, an implementation of a prospective influenza surveillance methodology based on a client-server architecture with a thin (web-based) client application design. Users can introduce and edit their own data consisting of a series of weekly influenza incidence rates. The system returns the probabilit…
Temas e interpretaciones del derecho sucesorio italiano
2021
El articulo quiere mostrar que las interpretaciones de las instituciones del derecho de sucesiones que consideran el interés familiar, como expresión del principio de solidaridad (cada vez más en una protección patrimonialista de la legitimidad), siempre prevalente sobre todos los demás intereses, ya no pueden ser compartidas, porque la solidaridad no se distingue del personalismo. Modernizar el derecho de sucesiones no significa tener que abdicar en favor del contrato, sino descubrir el valor de la autonomía privada y el potencial del acto de última voluntad. Es la centralidad de la persona humana y no sólo el principio de solidaridad (más aún si se entiende en un sentido patrimonialista) …
A comparative study on the dynamic response of three semisubmersible floating offshore wind turbines
2019
Abstract Currently, there is a great interest to globally develop offshore wind energy due to the greenhouse effect and energy crisis. Great efforts have been devoted to develop reliable floating offshore wind energy technology to exploit the wind energy resources in deep seas. This paper presents a comparative study of the dynamic response of three different semisubmersible floating wind turbine structures. All the three platforms support the same 5MW wind turbine. The platforms examined are: a V-shaped Semi, an OC4-DeepCwind Semi and a Braceless Semi at 200 m water depth. A dynamic analysis is carried out in order to calculate and compare the performance of these platforms. The comparison…