Search results for "58"
showing 10 items of 2229 documents
Guest Editors' Introduction: Supporting Urgent Basic Reading Skills in Children in Africa and Around the World
2014
Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
2021
Both the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury. Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner. During inflammation and its resolution, polymorphonuclear cells (PMNs) and macrophages switch from producing pro-inflammatory prostaglandins and leukotrienes to specialized pro-resolving lipid mediators (SPMs), namely, lipoxins, resolvins, protectins, and maresins, which are operative at the local level to limit further inflammation and tissue injury and restore homeostasis. Accumulating evidences expand now the rol…
Computational cluster validation for microarray data analysis: experimental assessment of Clest, Consensus Clustering, Figure of Merit, Gap Statistic…
2008
Abstract Background Inferring cluster structure in microarray datasets is a fundamental task for the so-called -omic sciences. It is also a fundamental question in Statistics, Data Analysis and Classification, in particular with regard to the prediction of the number of clusters in a dataset, usually established via internal validation measures. Despite the wealth of internal measures available in the literature, new ones have been recently proposed, some of them specifically for microarray data. Results We consider five such measures: Clest, Consensus (Consensus Clustering), FOM (Figure of Merit), Gap (Gap Statistics) and ME (Model Explorer), in addition to the classic WCSS (Within Cluster…
Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments.
2022
AbstractBackgroundA recent genome-wide association study (GWAS) identified 12 independent loci significantly associated with attention-deficit/hyperactivity disorder (ADHD). Polygenic risk scores (PRS), derived from the GWAS, can be used to assess genetic overlap between ADHD and other traits. Using ADHD samples from several international sites, we derived PRS for ADHD from the recent GWAS to test whether genetic variants that contribute to ADHD also influence two cognitive functions that show strong association with ADHD: attention regulation and response inhibition, captured by reaction time variability (RTV) and commission errors (CE).MethodsThe discovery GWAS included 19 099 ADHD cases …
Cross-Device Augmented Reality Annotations Method for Asynchronous Collaboration in Unprepared Environments
2021
Augmented Reality (AR) annotations are a powerful way of communication when collaborators cannot be present at the same time in a given environment. However, this situation presents several challenges, for example: how to record the AR annotations for later consumption, how to align virtual and real world in unprepared environments or how to offer the annotations to users with different AR devices. In this paper we present a cross-device AR annotation method that allows users to create and display annotations asynchronously in environments without the need for prior preparation (AR markers, point cloud capture, etc.). This is achieved through an easy user-assisted calibration process and a …
Incidence of potential drug interactions in a transplant centre setting and relevance of electronic alerts for clinical practice support
2013
Background Adverse drug events may occur as a result of drug–drug interactions (DDIs). Information technology (IT) systems can be an important decision-making tool for healthcare workers to identify DDIs.Objective The aim of the study is to analyse drug prescriptions in our main hospital units, in order to measure the incidence and severity of potential DDIs. The utility of clinical decision-support systems (CDSSs) and computerised physician order entry (CPOE) in term of alerts adherence was also assessed. DDIs were assessed using a Micromedex healthcare series database.Methods The system, adopted by the hospital, generates alerts for prescriptions with negative interactions and thanks to a…
Representações sociais, sens pratique, poder simbólico e o processo de construção do ser docente
2019
A partir de las elaboraciones teóricas de los fundadores del campo de investigación de las representaciones sociales, se pretende avanzar en la construcción de un diálogo entre esta teoría y la praxis social de Pierre Bourdieu, centrándose en la relación entre las representaciones sociales, la praxis sensorial (como manifestación del hábito) y el poder simbólico, dimensión ausente en el modelo moscoviciano. La base empírica a partir de la cual se desarrollan las reflexiones presentes en este artículo se apoya en investigaciones realizadas sobre el proceso de construcción del ser docente, en la realidad de algunas ciudades del nordeste brasileño. En este sentido, se destaca lo que se cree qu…
El dinamismo conversacional: subsunción y feed-back. Carácter acumulativo de los elementos conversacionales
1992
Los estudiosos de la conversación coinciden en señalar el carácter especial de la relación que une a dos hablantes en un encuentro verbal. Nuestro objetivo en el presente estudio es profundizar un poco más en tales relaciones. Analizaremos, pues, algunos de los rasgos fundamentales a los que se subordina una toma de turno conversacional, como la relación que vincula al hablante y los oyentes, los canales de retroalimentación, la construcción colaborativa de los enunciados o la progresión acumulativa que caracteriza la información. Englobaremos todas estas cuestiones bajo el nombre genérico de dinamismo conversacional.
Analysis of the covers of textbooks of Primary Physical Education
2017
Esta investigación analiza las imágenes del cuerpo humano y el tipo de actividad física que practica en las portadas de los libros de texto del área de Educación Física (EF) en Educación Primaria (EP), para determinar si reproducen y transmiten estereotipos en relación al sexo, raza, cuerpo, discapacidad y actividad física en función del currículum. La muestra universo consta de 30 portadas, publicadas bajo la Ley Orgánica de Educación (LOE). Los resultados muestran portadas preferentemente dibujadas y en color, los protagonistas de la actividad física son niños y niñas conjuntamente (agrupación mixta), pero a la vez permanecen estereotipos de raza (blanca) y somatotipo (ectomorfo) realizan…
Species–area relationships in continuous vegetation: Evidence from Palaearctic grasslands
2019
Aim Species-area relationships (SARs) are fundamental scaling laws in ecology although their shape is still disputed. At larger areas, power laws best represent SARs. Yet, it remains unclear whether SARs follow other shapes at finer spatial grains in continuous vegetation. We asked which function describes SARs best at small grains and explored how sampling methodology or the environment influence SAR shape. Location Palaearctic grasslands and other non-forested habitats. Taxa Vascular plants, bryophytes and lichens. Methods We used the GrassPlot database, containing standardized vegetation-plot data from vascular plants, bryophytes and lichens spanning a wide range of grassland types throu…