Search results for "617"
showing 10 items of 100 documents
Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever
2017
Arenaviruses such as Lassa virus (LASV) cause hemorrhagic fever. Terminal shock is associated with a systemic cytokine storm, but the mechanisms are ill defined. Here we used HLA-A2-expressing mice infected with a monkey-pathogenic strain of lymphocytic choriomeningitis virus (LCMV-WE), a close relative of LASV, to investigate the pathophysiology of arenavirus hemorrhagic fever (AHF). AHF manifested as pleural effusions, edematous skin swelling, and serum albumin loss, culminating in hypovolemic shock. A characteristic cytokine storm included numerous pro-inflammatory cytokines and nitric oxide (NO) metabolites. Edema formation and terminal shock were abrogated in mice lacking inducible nit…
Mechanical ventilation alters the development of staphylococcus aureus pneumonia in rabbit
2016
Ventilator-associated pneumonia (VAP) is common during mechanical ventilation (MV). Beside obvious deleterious effects on muco-ciliary clearance, MV could adversely shift the host immune response towards a pro-inflammatory pattern through toll-like receptor (TLRs) up-regulation. We tested this hypothesis in a rabbit model of Staphylococcus aureus VAP. Pneumonia was caused by airway challenge with S. aureus, in either spontaneously breathing (SB) or MV rabbits (n = 13 and 17, respectively). Pneumonia assessment regarding pulmonary and systemic bacterial burden, as well as inflammatory response was done 8 and 24 hours after S. aureus challenge. In addition, ex vivo stimulations of whole blood…
Drugs and diseases: Summary and consensus statements of group 1. The 5th EAO Consensus Conference 2018
2018
OBJECTIVES: The task of this working group was to update the knowledge about the use of drugs and biologicals affecting healing of soft tissue and bone during implant treatment or procedures associated with it. Moreover, the impact of titanium particles and biocorrosion on complications and implant survival has been analysed. MATERIALS AND METHODS: The literature in the areas of interest (platelet concentrates, antiresorptive drugs as well as implant-host interaction) was screened using systematic reviews for the former two areas, whereas a narrative critical review was performed for the latter topic. Two manuscripts on platelet concentrates, one manuscript on antiresorptive drugs and one m…
Is the pelvis-thorax coordination a valuable outcome instrument to assess patients with Hip osteoarthritis?
2020
Objective: The evaluation of the disease severity in hip osteoarthritis (OA) patients being currently based on subjective instruments. It would be of interest to develop more objective instruments, for example based on gait analysis. The aims of this study were to explore if pelvis-thorax coordination parameters could be valuable instrument outcomes to achieve this evaluation by assessing their reliability, discriminant capacity and responsiveness. Methods: Three groups of subjects; healthy, hip OA patients with severe disease (defined as indication to surgery), hip OA patients with less severe disease (no indication to surgery) were included. Hip OA patients with severe disease were evalua…
Validity and reliability of the CatWalk system as a static and dynamic gait analysis tool for the assessment of functional nerve recovery in small an…
2017
Introduction: A range of behavioral testing paradigms have been developed for the research of central and peripheral nerve injuries with the help of small animal models. Following any nerve repair strategy, improved functional outcome may be the most important evidence of axon regeneration. A novel automated gait analysis system, the CatWalk™, can measure dynamic as well as static gait patterns of small animals. Of most interest in detecting functional recovery are in particular dynamic gait parameters, coordination measures, and the intensity of the animals paw prints. This article is designed to lead to a more efficient choice of CatWalk parameters in future studies concerning the functio…
Valoración de técnicas de luz estructurada en la determinación de deformidades del raquis
2002
Título: VALORACIÓN DE TÉCNICAS DE LUZ ESTRUCTURADA EN LA DETERMINACIÓN DE LAS DEFORMIDADES DEL RAQUIS.Introducción: En los últimos años se ha observado un desarrollo de los métodos indirectos, entre los que se encuentra la luz estructurada, aplicados al estudio de las deformidades del raquis, y fundamentalmente, de la escoliosis idiopática. Esto se debe al interés por disminuir el número de exploraciones radiográficas, cuantificar la deformidad externa y caracterizar correctamente una patología que tiene lugar en los tres planos del espacio y que clásicamente viene siendo representada por el ángulo de Cobb. Objetivo: 1) Es la puesta a punto, para su utilización en la práctica clínica, de un…
Accidentabilidad laboral: Accidentes oculares.
2005
INTRODUCCIONEl número de accidentes de trabajo es elevado. España tiene el índice más alto de accidentes no mortales de toda la Unión Europea y el tercero en los accidentes mortales.Su coste económico oscila sobre los 1200 millones de euros al año. En Estados Unidos, España, Suiza, Latinoamérica y el Caribe representa el 2-4% del PIB.Los accidentes oculares constituyen el 10% de todos los accidentes del cuerpo, y suelen ser leves.MATERIAL Y METODOHemos estudiado los accidentes de trabajo con baja ocurridos a los trabajadores que tienen cubierta dicha contingencia.Los documentos fueron el parte de accidente de trabajo con baja y la relación de altas o fallecimientos.En el estudio de los cost…
Aportación de la radioterapia guiada por la imagen al tratamiento del cáncer de próstata
2010
Objetivo: Demostrar que la verificación mediante Cone Beam CT (CBCT) en una serie de pacientes tratados con radioterapia externa 3D (RTE3D) por su cáncer de próstata (CP) se relaciona con una reducción de los niveles de toxicidad aguda y tardía. Material y Métodos: Se ha realizado un estudio retrospectivo no aleatorizado de 2 grupos homogéneos de pacientes tratados entre 2005 y 2008, 46 pacientes verificados mediante Electronic Portal Devices (EPIC) y 48 verificados mediante CBCT (Electa Synergy), con una mediana de edad de 67 años (42-85 años). Recibieron RTE3D por CP estadio localizado ( T1-T3b N0 M0 ), prescribiéndose las mismas dosis, simulados y planificados con los mismos criterios y …
Repercusiones laborales en usuarios de pantallas de visualización de datos tras cirugía refractiva.
2006
Objetivo:Evaluar la influencia en la calidad percibida de visión y en el ámbito laboral de los trabajadores usuarios de pantallas de visualización de datos que se asocia a la mejora de la función visual tras queratomileusis in situ con láser excimer (LASIK).Métodos:Estudio observacional y longitudinal en una población de 96 pacientes intervenidos de cirugía refractiva con láser excimer según técnica LASIK mediante aplicación de un cuestionario construido al efecto aplicado antes y después de cirugía por un observador independiente.Las edades de los pacientes variaban entre los 21 y los 60 años. Entre ellos hay 54 mujeres y 42 hombres. Y poseían errores refractivos entre - 1 y - 10 D de miop…
La sentencia y su ejecución en el proyecto dominicano de ley sobre control judicial de la administración pública
2021
The regime of the execution of the sentence is analyzed, starting from the powers of declarative and executive substitution of the contentious-administrative judge. It begins with the reference to the constitutional guidelines of the administrative process. Then, the different modalities of judicial substitution are described in the types of sentences (declarative, constitutive and conviction) regulated in the project, to then refer to the regime of executive seizure of public goods. It ends by describing: the powers granted to the judge to agree indirect measures that assist with the execution of the judgment, the cases of impossibility of execution and the extension of the sentence to thi…