Search results for "62"
showing 10 items of 970 documents
Identification of Biphenyl-Based Hybrid Molecules Able To Decrease the Intracellular Level of Bcl-2 Protein in Bcl-2 Overexpressing Leukemia Cells
2009
With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on apoptosis and differentiation, making them potential leads for development as new anticancer agents and chemical probes to study signaling networks in neoplastic cells.
Antimicrobial and antiproliferative activity of Peucedanum nebrodense (Guss.) Strohl.
2003
Abstract Acetone extract of Peucedanum nebrodense (Guss.) Strohl., a rare endemic species from the Madonie mountains (Sicily), was tested in vitro for its antimicrobial activity against bacterial reference strains and antiproliferative activity against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and L1210 (murine leukemia) cell lines. The acetone extract showed antiproliferative IC 50 values in the range of 14–0.27 μg/ml.
ChemInform Abstract: (a)-Anellated Carbazoles with Antitumor Activity: Synthesis and Cytotoxicity.
2010
The cycloadducts3,5, and7, readily available from methoxy-substituted 3-vinylindoles1 and2, were dehydrogenated withDDQ to the coplanar [a]-anellated carbazoles4,6, and8. Compound4a, also characterized by X-ray structural analysis, shows significant cytotoxicity against K562 und RXF393 human tumor cell lines.
Stress concentration for closely located inclusions in nonlinear perfect conductivity problems
2019
We study the stress concentration, which is the gradient of the solution, when two smooth inclusions are closely located in a possibly anisotropic medium. The governing equation may be degenerate of $p-$Laplace type, with $1<p \leq N$. We prove optimal $L^\infty$ estimates for the blow-up of the gradient of the solution as the distance between the inclusions tends to zero.
La factoría de la Empresa Nacional Elcano en Manises : una valoración patrimonial
2010
La factoría de la Empresa Nacional Elcano de Manises (Valencia) fue construida entre 1946 y 1953 dentro de los planes estatales de reconstrucción industrial de la postguerra. Sus arquitecturas plantean una dualidad entre la modernidad y racionalidad de los espacios productivos y la tradición historicista de los edificios representativos, directamente relacionada con los programas ideológicos del Régimen. De su valoración a partir de los criterios establecidos por el Ministerio de Cultura para el Plan Nacional de Patrimonio Industrial, se desprende el extraordinario valor de la factoría como conjunto, el cual se sitúa por encima de la ya alta calidad de sus edificios a nivel individual, por …
Juan II de Aragón y las artes suntuarias
2015
Producción Científica
The role of contact chemoreception in the host location process of an egg parasitoid
2016
Taste allows insects to detect palatable or toxic foods, identify a mate, and select appropriate oviposition sites. The gustatory system strongly contributes to the survival and reproductive success of many species, yet it is rarely studied in insect parasitoids. In order to locate and assess a host in which they will lay their eggs, female wasps actively search for chemical cues using their sensory organs present mainly on the antennae. In this paper, we studied the role of antennal taste sensilla chaetica in the perception of contact semiochemicals in Trissolcus brochymenae (Hymenoptera: Platygastridae), an egg parasitoid of the brassicaceae pest Murgantia histrionica (Heteroptera: Pentat…
The Polarized Image of a Synchrotron-emitting Ring of Gas Orbiting a Black Hole
2021
Full list of authors: Narayan, Ramesh; Palumbo, Daniel C. M.; Johnson, Michael D.; Gelles, Zachary; Himwich, Elizabeth; Chang, Dominic O.; Ricarte, Angelo; Dexter, Jason; Gammie, Charles F.; Chael, Andrew A.; Event Horizon Telescope Collaboration; Akiyama, Kazunori; Alberdi, Antxon; Alef, Walter; Algaba, Juan Carlos; Anantua, Richard; Asada, Keiichi; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David Baloković, Mislav; Barrett, John; Benson, Bradford A.; Bintley, Dan; Blackburn, Lindy; Blundell, Raymond; Boland, Wilfred; Bouman, Katherine L.; Bower, Geoffrey C.; Boyce, Hope; Bremer, Michael; Brinkerink, Christiaan D.; Brissenden, Roger; Britzen, Silke; Broderick, Avery E.; Broguiere, Domini…
EVIDENCE OF NON-THERMAL X-RAY EMISSION FROM HH 80
2013
Protostellar jets appear at all stages of star formation when the accretion process is still at work. Jets travel at velocities of hundreds of km s -1, creating strong shocks when interacting with the interstellar medium. Several cases of jets have been detected in X-rays, typically showing soft emission. For the first time, we report evidence of hard X-ray emission possibly related to non-thermal processes not explained by previous models of the post-shock emission predicted in the jet/ambient interaction scenario. HH 80 is located at the south head of the jet associated with the massive protostar IRAS 18162-2048. It shows soft and hard X-ray emission in regions that are spatially separate…
Search for heavy neutral lepton production in K+ decays to positrons
2020
A search for heavy neutral lepton ($N$) production in $K^+\to e^+N$ decays using the data sample collected by the NA62 experiment at CERN in 2017--2018 is reported. Upper limits of the extended neutrino mixing matrix element $|U_{e4}|^2$ are established at the level of $10^{-9}$ over most of the accessible heavy neutral lepton mass range 144--462 MeV/$c^2$, with the assumption that the lifetime exceeds 50 ns. These limits improve significantly upon those of previous production and decay searches. The $|U_{e4}|^2$ range favoured by Big Bang Nucleosynthesis is excluded up to a mass of about 340 MeV/$c^2$.