Search results for "62"
showing 10 items of 970 documents
La investigación en el diseño. Un modelo basado en la experiencia
2010
Vicent Garcia, poeta europeu
2012
Després de repassar la bibliografia crítica i els textos poètics derivats, es procedeix a l’anàlisi d’un conegut sonet de Francesc Vicent Garcia, rector de Vallfogona (1578/1579-1623): «A una hermosa dama de cabell negre, que es pentinava en un terrat ab una pinta de marfil», que comença «Ab una pinta de marfil polia», en què l’autor mostra una habilitat poètica excepcional. S’insereix després el text en el seu context estètic i històric, el barroc europeu, i finalment se’l compara amb una sèrie de sonets equivalents, sobre el mateix motiu, produïts per autors castellans, portuguesos, italians i francesos. S’hi conclou que el de Garcia és molt original, tot i la forta codificació de la sèri…
First-in-human study of IMAB362, an anti-claudin 18.2 monoclonal antibody, in patients with advanced gastroesophageal cancer
2017
Quantitative lower bounds to the Euclidean and the Gaussian Cheeger constants
2020
We provide a quantitative lower bound to the Cheeger constant of a set $\Omega$ in both the Euclidean and the Gaussian settings in terms of suitable asymmetry indexes. We provide examples which show that these quantitative estimates are sharp.
WT1 isoform expression pattern in acute myeloid leukemia.
2013
WT1 plays a dual role in leukemia development, probably due to an imbalance in the expression of the 4 main WT1 isoforms. We quantify their expression and evaluate them in a series of AML patients. Our data showed a predominant expression of isoform D in AML, although in a lower quantity than in normal CD34+ cells. We found a positive correlation between the total WT1 expression and A, B and C isoforms. The overexpression of WT1 in AML might be due to a relative increase in A, B and C isoforms, together with a relative decrease in isoform D expression.
Targeting Aberrant Ncam (neural cell adhesion molecule; CD56) Expression in Acute Myeloid Leukemia
2015
Abstract Background Acute myeloid leukemia (AML) is a heterogeneous disease of the hematopoietic progenitor cell driven by the subsequent acquisition of genetic alterations. Approximately 20% of AML patients show strong expression of CD56 (neural cell adhesion molecule; NCAM). Expression of NCAM is associated with poor overall survival; however, the functional role of aberrant NCAM expression has not been investigated to date. The goal of this study is to examine the biological role of NCAM in AML and to explore whether NCAM represents a potential therapeutic target. Results In order to evaluate the clinical significance of elevated NCAM expression in AML, we screened a panel of human cell …
SARS-CoV-2 mRNA Vaccine Breakthrough Infections in Fully Vaccinated Healthcare Personnel: A Systematic Review
2022
The number of people vaccinated against COVID-19 increases worldwide every day; however, it is important to study the risk of breakthrough infections in vaccinated individuals at high risk of exposure such as healthcare personnel (HCP). A systematic literature review (SLR) applying the PRISMA declaration and the PECOS format using the following entry terms was used: “Health Personnel OR Healthcare Worker OR Healthcare Provider OR Healthcare Personnel AND breakthrough OR infection after vaccine*”. The research was carried out utilizing the following databases: SCOPUS, PubMed, Embase, and Web of Sciences. An overall very low incidence of post-vaccination breakthrough infections was found, ran…
Complete karyotype characterization of the K562 cell line by combined application of G-banding, multiplex-fluorescence in situ hybridization, fluores…
2001
This study combines conventional cytogenetics, fluorescence in situ hybridization (FISH), multiplex-FISH and comparative genomic hybridization (CGH). In applying this multimodal approach on the human leukemia cell line K562, the chromosome composition was refined in detail and compared with data from the literature. A hypotriploid karyotype with a modal chromosome number of 67, and 21 unique marker chromosomes were identified. The classification of six markers was identical to published data and the composition of five further markers from the literature could be fully clarified for the first time. The composition of another five markers, which have been interpreted in divergent ways in dif…
Redes de colaboración y autorías científicas sobre la enfermedad de Chagas: análisis de las publicaciones indexadas en PubMed (1940-2009)
2012
Chagas disease is a chronic, tropical, parasitic disease, endemic throughout Latin America. The large-scale migration of populations has increased the geographic distribution of the disease and cases have been observed in many other countries around the world. To strengthen the critical mass of knowledge generated in different countries, it is essential to promote cooperative and translational research initiatives. We analyzed authorship of scientific documents on Chagas disease indexed in the Medline database from 1940 to 2009. Bibliometrics was used to analyze the evolution of collaboration patterns. A Social Network Analysis was carried out to identify the main research groups in the are…
La hospitalización domiciliaria: antecedentes, situación actual y perspectivas
2001
Objetivo. Determinar las distintas variantes que ha tenido el concepto de la hospitalización domiciliaria a lo largo del tiempo, para así contribuir al debate sobre las circunstancias que inciden en la gestión sanitaria frente a futuros retos. Métodos. Se revisa la literatura sobre la atención domiciliaria como modalidad asistencial de salud mediante una exploración de las publicaciones indizadas en MEDLINE, LILACS y el Índice Médico Español durante el período de 1995-2000. Resultados. La hospitalización domiciliaria ha tenido un desarrollo desigual a lo largo del tiempo en diferentes países y son varios los modelos de este tipo de atención, cada uno con sus respectivas ventajas y desventaj…