Search results for "62"
showing 10 items of 970 documents
Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning
2021
Recent evidence suggests that, in some foci, elimination of onchocerciasis from Africa may be feasible with mass drug administration (MDA) of ivermectin. To achieve continental elimination of transmission, mapping surveys will need to be conducted across all implementation units (IUs) for which endemicity status is currently unknown. Using boosted regression tree models with optimised hyperparameter selection, we estimated environmental suitability for onchocerciasis at the 5 × 5-km resolution across Africa. In order to classify IUs that include locations that are environmentally suitable, we used receiver operating characteristic (ROC) analysis to identify an optimal threshold for suitabil…
Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts
2018
Source at https://doi.org/10.1186/s13058-018-1073-0. Licensed CC BY-NC-ND 4.0. Background: Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, we examined whether modeling this heterogeneity could improve prediction. Methods: We built two models, for ER+ (ModelER+) and ER- tumors (ModelER-) , respectively, in 281,330 women (51% postmenopausal at recruitment) from the European Prospective Investigation into Cancer and Nutrition cohort. Discrimination (C-statistic) and calibration (the agreement between predicted and observed tumor risks)…
Phase 1 Study of IMAB362 with immunomodulation in patients with advanced gastric cancer
2017
220O Claudin 18.2 - a novel treatment target in the multicenter, randomized, phase II FAST study, a trial of epirubicin, oxaliplatin, and capecitabin…
2016
Integrating Telemedicine Solutions with Electronic Health Records; Evaluation of Alternatives based on the Proposed Reference Architecture for Norway…
2016
This report studies the way forward for how a telemedicine solution can be integrated for exchange of data with an existing Electronic Health Record (EHR) system. The solution used an example for this report is based on a telemedicine solution for COPD patients (Chronic Obstructive Pulmonary Disease) developed in the project “Collaborative Point-of-Care Services Agder: Follow-up of COPD patients as part of the United4Health EU Project», with financial support from the Research Council of Norway. In addition, the EHR solution from DIPS ASA is used as an example of an existing system for integration. Important parameters for choosing way forward on how to are: urgency with regards to timeli…
CONVENTIONAL INTERNAL LIMITING MEMBRANE PEELING VERSUS INVERTED FLAP FOR SMALL-TO-MEDIUM IDIOPATHIC MACULAR HOLE
2022
Purpose: To compare conventional internal limiting membrane (ILM) peeling versus inverted flap technique in small-to-medium idiopathic macular hole. Methods: Eyes with ≤400 μ m idiopathic macular holes were randomized into the conventional ILM peeling group (25 eyes) and inverted flap group (25 eyes). A 12-month follow-up was considered. Macular sensitivity (MS) change detected with MP-1 microperimetry was the primary outcome. Secondary outcomes included best-corrected visual acuity change, closure rate, anatomical findings on optical coherence tomography such as U-shape foveal contour, restoration of external limiting membrane, and ellipsoid zone. Results: In both groups, MS improved throu…
Deformable object segmentation in ultra-sound images
2013
Breast cancer is the second most common type of cancer being the leading cause of cancer death among females both in western and in economically developing countries. Medical imaging is key for early detection, diagnosis and treatment follow-up. Despite Digital Mammography (DM) remains the reference imaging modality, Ultra-Sound (US) imaging has proven to be a successful adjunct image modality for breast cancer screening, specially as a consequence of the discriminative capabilities that US offers for differentiating between solid lesions that are benign or malignant. Despite US usability,US suffers inconveniences due to its natural noise that compromises the diagnosis capabilities of radio…
Oracion funebre, en las exequias que en 11 de Iulio del año 1699 hizo la Santa Metropolitana Iglesia de Valencia al ... Señor Don Fray Iuan Thomas …
1699
El f. de làm. és el retrat de Tomàs de Rocabertí Port. con orla tip. Caplletres ornades, fris Sign.: [ ]3, œœ2, A-E4, F3 Text amb postil·les marginals Reclams
Brief an Garlieb H. Merkel
1799
Ms. 930a, Nr. 8, Bl. 22r-23v Böttiger, Karl August. Brief an Garlieb H. Merkel, Weimar, d[en] 13. November 1797 Autora rokraksts / Autograph, vācu, angļu un latīņu val. / Deutsch, Englisch und Latein [4] lpp. / S. Attēlu numuri / Bildnummern: 930a-008-1 – 930a-008-4 Der Verfasser nennt in diesem inhaltsreichen Brief zahlreiche Namen und hält nicht nur die Verbindung mit Merkel, die aus dessen erstem Aufenthalt in Weimar resultierte, aufrecht, sondern gibt ihm weitere Hinweise und Empfehlung für seinen weiteren Aufenthalt in Dänemark. So rät er zur Übersetzung dreier Romane aus dem Englischen, darunter Jane Wests „A gossip's story“ (London 1796). Ferner bittet der Verfasser Merkel um Gefälli…
Erosion and screening of tungsten during inter/intra-ELM periods in the JET-ILW divertor
2020
Abstract Intra-ELM tungsten sources, which dominate the total W source, are quantified in the inner and outer divertor of JET-ILW. The amount of the sputtered W atoms for individual ELMs demonstrates a clear dependence on the ELM frequency. It decreases when the pedestal temperature is lower and, correspondingly, the ELM frequency is higher. Nevertheless, the entire gross erosion W source (the number of eroded W atoms per second due to ELMs) increases initially with ELM frequency and reaches its maximum at fELM ≈ 50–55 Hz followed by its reduction in the high frequency range. The in/out asymmetry of the intra-ELM W sources during ELMs is a critical issue and is investigated in this contribu…