Search results for "63"
showing 10 items of 724 documents
Cytokine Polymorphism in Takotsubo Cardiomyopathy
2014
IMIN11. Cytokine Polymorphism in Takotsubo Cardiomyopathy P. Di Gangi1, L. Scola1, S. Giambanco1, M. Bova1, G. Santini1, L. Vaccarino1, C. R. Balistreri1, D. Lio1, P. Assennato1, S. Novo1, G. Novo1 1University of Palermo, Palermo, Italy Background: Takotsubo (TT) cardiomyopathy is characterised by an acute left ventricular dysfunction triggered by emotional or physical stresses. Clinically, the syndrome is characterised by acute symptoms mimicking acute infarction without relevant electrocardiographic and biochemical markers of myocardial damage changes. Stressful events inducing an excess catecholamine release and myocardial β-adrenergic receptors (β-AR) seem to play a major role in TT. Ac…
Observaciones, sobre un tratado, que escrivio ... Fr. Diego Tello, con el titulo de Suffragio a la piedad, con que la Nacion Española desea, y solic…
1750
Sig. A-S2 Escut xil. dels mercedaris al final Reclams. - Cristus
A decidable multi-modal logic of context
1997
We give a logic for formulas Á¡± Ã, with the informal reading ”à is true in the context described by Á”. These are interpreted as binary modalities, by quantification over an enumerable set of unary modalities c¡± Ã, meaning ”à is true in context c”. The logic allows arbitrary nesting of contexts. A corresponding axiomatic presentation is given, and proven to be decidable, sound, and complete. Previously, quantificational logic of context restricted the nesting of contexts, and was only known to be decidable in very special cases.
Second-line administration of thrombopoietin receptor agonists in immune thrombocytopenia: Italian Delphi-based consensus recommendations
2021
Introduction: In patients with primary immune thrombocytopenia (ITP), a short course of steroids is routinely given as first-line therapy. However, the response is often transient and additional therapy is usually needed. Thrombopoietin receptor agonists (TPO-RAs) are frequently used as second-line therapy, although there is little clinical guidance on the timing of their administration and on tapering/discontinuation of the drug. To provide clinical recommendations, we used the Delphi technique to obtain consensus for statements regarding administration and on tapering/discontinuation of second-line TPO-RAs among a group of Italian clinicians with expertise in management of ITP. Methods: T…
The Essential Thrombocythemia, Thrombotic Risk Stratification, and Cardiovascular Risk Factors
2020
Essential thrombocythemia is a rare hematological malignancy with good overall survival, but moderate to high risk of developing arterial or venous thrombosis lifelong. Different thrombotic risk scores for patients with essential thrombocythemia have been proposed, but only one of them (the IPSET-t scoring system) takes into account the classical cardiovascular risk factors as one of the scoring items. Currently, in clinical practice, the presence of cardiovascular risk factors in patients with diagnosis of ET rarely determines the decision to initiate cytoreductive therapies. In our study, we compared different risk models to estimate the thrombotic risk of 233 ET patients and the role of …
D2R striatopallidal neurons inhibit both locomotor and drug reward processes.
2009
The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.
Photoelastic stress analysis assisted evaluation of fracture toughness in hydrothermally aged epoxies
2014
The present work has investigated the fracture toughness of a model DGEBA epoxy system subject to Hidro-Thermal aging. A Photoelastic Stress Analysis technique has been implemented, showing the evolution of stresses arising throughout the water uptake process due to the non-uniform swelling of the material. Gravimetric and Dynamic Mechanical Thermal Analyses have further complemented the characterization, showing the onset of plasticization effects with aging. The correlation of all previous characterizations has allowed to conclude that an increase of KIC fracture toughness is obtained at the fully saturated condition. In particular Photoelasticity has also revealed the onset of relevant s…
La protezione penale degli interessi finanziari UE: considerazioni sparse a un anno dalla Direttiva 2017/1371
2018
L’articolo analizza la Direttiva (UE) 2017/1371 in materia di tutela penale degli interessi finanziari UE, mettendola a confronto sia con la Convenzione PIF del 1995 e i suoi Protocolli del 1996 e 1997 sia con la Proposta di Direttiva 2012/363 della Commissione UE. Dal confronto emerge, in particolare, come la Direttiva, se costituisce un notevole progresso rispetto al sistema convenzionale pre-vigente, finisce invece per deludere le attese create dalla ben più coraggiosa proposta della Commissione. The article analyses the Directive (EU) 2017/1371 concerning the protection of EU financial interests by means of criminal law, comparing it both with the 1995 EU Convention and its Protocols, o…