Search results for "65"

showing 10 items of 1111 documents

Obesity causes PGC‐1α deficiency in the pancreas leading to marked IL‐6 upregulation via NF‐κB in acute pancreatitis

2019

Obesity is associated with local and systemic complications in acute pancreatitis. PPARγ coactivator 1α (PGC-1α) is a transcriptional coactivator and master regulator of mitochondrial biogenesis that exhibits dysregulation in obese subjects. Our aims were: (1) to study PGC-1α levels in pancreas from lean or obese rats and mice with acute pancreatitis; and (2) to determine the role of PGC-1α in the inflammatory response during acute pancreatitis elucidating the signaling pathways regulated by PGC-1α. Lean and obese Zucker rats and lean and obese C57BL6 mice were used first; subsequently, wild-type and PGC-1α knockout (KO) mice with cerulein-induced pancreatitis were used to assess the inflam…

MaleTaurocholic Acid0301 basic medicinemedicine.medical_specialtyPGC-1αPathology and Forensic Medicine03 medical and health sciencesDownregulation and upregulationInternal medicineAnimalsMedicineObesityPhosphorylationInterleukin 6PancreasCeruletideMice KnockoutIL-6biologyp65Interleukin-6business.industryNF-kappa BTranscription Factor RelAmedicine.diseasePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRats ZuckerUp-Regulation3. Good healthMice Inbred C57BLDisease Models Animal030104 developmental biologyEndocrinologymedicine.anatomical_structureMitochondrial biogenesisPancreatitisbiology.proteinPancreatitisAcute pancreatitisPPARGC1AbusinessPancreasCeruletideSignal TransductionThe Journal of Pathology
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Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients

2021

Abstract Obesity is increasing in patients with type 2 diabetes. A possible reduced association between fructosamine and glycated hemoglobin (HbA1c) in obese individuals has been previously discussed, but this has never been specifically evaluated in type 2 diabetes, and the potential influence of body fat mass and fat distribution has never been studied. We studied 112 type 2 diabetes patients with assessment of fat mass, liver fat and fat distribution. Patients with body mass index (BMI) above the median (34.9 kg/m2), versus BMI below the median, had a correlation coefficient between fructosamine and HbA1c significantly reduced (r = 0.358 vs r = 0.765). In the whole population, fructosami…

Maleendocrine system diseasesEndocrinology Diabetes and MetabolismType 2 diabetesObesechemistry.chemical_compound0302 clinical medicineProspective Studies2. Zero hunger[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismeducation.field_of_studyDiabetesGeneral MedicineArticles[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismMiddle AgedMagnetic Resonance ImagingFructosamineClinical Science and Care030220 oncology & carcinogenesisFructosamineFemalemedicine.medical_specialtyPopulationShort ReportAbdominal Fat030209 endocrinology & metabolismDiseases of the endocrine glands. Clinical endocrinologyFat mass03 medical and health sciencesDiabetes mellitusInternal medicineInternal MedicinemedicineHumansObesityeducationAgedGlycated Hemoglobinbusiness.industrynutritional and metabolic diseasesmedicine.diseaseRC648-665ObesityEndocrinologychemistryDiabetes Mellitus Type 2Glycated hemoglobinbusinessBody mass indexJournal of Diabetes Investigation
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Prognostic Impact of Hyponatremia and Hypernatremia in COVID-19 Pneumonia. A HOPE-COVID-19 (Health Outcome Predictive Evaluation for COVID-19) Regist…

2020

Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admittance dysnatremia is associated with mortality, sepsis, or intensive therapy (IT) in patients hospitalized with SARS-COV2 pneumonia. This is a retrospective study of the HOPE-COVID-19 registry, with data collected from January 1th through April 31th, 2020. We selected all hospitalized adult patients with RT-PCR-confirmed SARS-COV2 pneumonia and a registered admission serum sodium level (SNa). Patients were classified as hyponatremic (SNa <…

MalehyponatremiaEndocrinology Diabetes and Metabolism030204 cardiovascular system & hematologyGlobal Healthlcsh:Diseases of the endocrine glands. Clinical endocrinology:Health Care::Health Care Quality Access and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Outcome and Process Assessment (Health Care) [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]sepsis0302 clinical medicineEndocrinology:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Retrospective Studies [Medical Subject Headings]HiponatremiaOutcome Assessment Health CareSARS-COV2Hospital MortalityRegistriesOriginal Research:Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings]HypernatremiahypernatremiaMiddle AgedPrognosisVirusHospitalizationSurvival Rate:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization [Medical Subject Headings]HipernatremiaFemaleHyponatremiaHyponatremiamedicine.medical_specialty:Information Science::Information Science::Data Collection::Vital Statistics::Mortality::Survival Rate [Medical Subject Headings]Coronavirus disease 2019 (COVID-19)Infecciones por coronavirus:Check Tags::Male [Medical Subject Headings]030209 endocrinology & metabolismSepsis03 medical and health sciencesInternal medicineSepsis:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings]medicineHumans:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Water-Electrolyte Imbalance::Hypernatremia [Medical Subject Headings]MortalitySurvival rateAgedRetrospective Studieslcsh:RC648-665business.industrySARS-CoV-2COVID-19Retrospective cohort study:Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Aparato respiratoriomedicine.diseasemortality:Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [Medical Subject Headings]Clinical trialbody regionsPneumonia:Check Tags::Female [Medical Subject Headings]:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Water-Electrolyte Imbalance::Hyponatremia [Medical Subject Headings]Mortalidad:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Hospital Mortality [Medical Subject Headings]HypernatremiabusinessFollow-Up Studies
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Glycemic Dysregulations Are Associated With Worsening Cognitive Function in Older Participants at High Risk of Cardiovascular Disease: Two-Year Follo…

2021

The authors wish to thank the PREDIMED-Plus participants and staff for their engagement, as well as to the primary care centers involved in the study. We also thank the Cerca Programme of the Generalitat de Catalunya, and the CIBEROBN, CIBERESP and CIBERDEM initiatives of Instituto de Salud Carlos III in Spain, and the collaborators in the PRIME consortium for helpful input. The first version of the present article has been published in the public repository Research Square as a preprint publication of our work (44). We particularly thank Stephanie Nishi for her assistance with manuscript language revision.

Malemedicine.medical_specialtyCognition disordersEndocrinology Diabetes and Metabolism030209 endocrinology & metabolismGlycemic ControlprediabetesType 2 diabetesdiabetes durationTrastorns de la cognicióDiseases of the endocrine glands. Clinical endocrinology03 medical and health scienceschemistry.chemical_compoundCognitionEndocrinology0302 clinical medicineInsulin resistanceinsulin resistanceDiabetes mellitusInternal medicinemedicineHumansHypoglycemic AgentsCognitive DysfunctionProspective StudiesPrediabetesglycated (glycosylated) hemoglobinCognitive declinecognitive functionAgedGlucose Metabolism DisordersOriginal ResearchGlycemicDiabetisbusiness.industryMalalties cardiovascularsDiabetesMiddle AgedRC648-665medicine.disease3. Good healthCardiovascular diseaseschemistryFemaletype 2 diabetesGlycated hemoglobinMetabolic syndromebusiness030217 neurology & neurosurgery
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Is complying with the recommendations of sodium intake beneficial for health in individuals at high cardiovascular risk? Findings from the PREDIMED s…

2015

Background: Excess sodium intake is associated with high blood pressure, a major risk factor for cardiovascular disease (CVD). It is unknown whether decreasing sodium intake to ,2300 mg/d has an effect on CVD or all-cause mortality. Objective: The objective was to assess whether reductions in sodium intake to ,2300 mg/d were associated with either an increased or a decreased risk of fatal and nonfatal CVD and all-cause mortality. Design: This observational prospective study of the PREvencicon DIeta MEDiterr� (PREDIMED) trial included 3982 participants at high CVD risk. Sodium intake was evaluated with a validated food- frequency questionnaire and categorized as low (,1500 mg/d), in- termedi…

Malemedicine.medical_specialtyMediterranean dietMedicine (miscellaneous)Health Promotion0002-9165Lower riskDiet MediterraneanSistema cardiovascular malaltiesBioquímica i biotecnologiaGastroenterologyDieta mediterràniaNutrition PolicyCohort StudiesPatient Education as TopicRisk FactorsInternal medicineMediterranean dietmedicinePrevalenceMortalitatHumansRisk factorMortalityProspective cohort studyAgedAged 80 and overBioquímica y tecnologíaNutrition and Dieteticsbusiness.industryProportional hazards modelIncidence (epidemiology)IncidenceDiet Sodium-RestrictedMiddle AgedSurgeryBiochemistry and technologyCardiovascular diseasesCardiovascular DiseasesSpainRelative riskPatient ComplianceFemalebusinessCohort studyFollow-Up Studies
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The predictive role of atherogenic dyslipidemia in subjects with non-coronary atherosclerosis

2009

Abstract Background Recent findings have suggested that subjects with non-coronary atherosclerosis may show elevated prevalence of atherogenic dyslipidemia, including higher triglyceride levels, reduced HDL-cholesterol concentrations and increased levels of small, dense low-density lipoproteins (LDL). These three lipid abnormalities constitute the so-called “atherogenic-lipoprotein-phenotype” (ALP) but its predictive role in these patients still remains to be established. Methods We performed a 2-year follow-up study to assess clinical and biochemical predictors of cardiovascular events in 44 male patients (64 ± 5 years, BMI: 27 ± 3), 26 with peripheral arterial disease and 18 with abdomina…

Malemedicine.medical_specialtyMultivariate analysis1303 BiochemistryClinical Biochemistry10265 Clinic for Endocrinology and Diabetology610 Medicine & health1308 Clinical Biochemistry2704 Biochemistry (medical)Biochemistrychemistry.chemical_compoundRisk Factorsatherogenic dyslipidemiaInternal medicineDiabetes mellitusmedicineHumansFamily historyCoronary atherosclerosisDyslipidemiasPeripheral Vascular DiseasesUnivariate analysisTriglyceridebusiness.industryBiochemistry (medical)Cholesterol LDLGeneral MedicineMiddle AgedAtherosclerosismedicine.diseaseAbdominal aortic aneurysmPeripheralPhenotypechemistryCase-Control StudiesMultivariate AnalysisCardiologyAtherosclerosis HDL-cholesterol Triglycerides Small dense LDL Atherogenic lipoprotein phenotypebusinessAortic Aneurysm AbdominalFollow-Up Studies
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Image-Guided Thermal Ablation as an Alternative to Surgery for Papillary Thyroid Microcarcinoma: Preliminary Results of an Italian Experience

2021

PurposeTo report the results of our preliminary experience in treating patients with papillary thyroid microcarcinoma (PTMC) with image-guided thermal ablation, in particular estimating the feasibility, safety and short-term efficacyMaterials and MethodsFrom 2018 patients with cytologically proven PTMC < 10 mm were discussed in a multidisciplinary team and evaluated for feasibility of image-guided thermal ablation. In case of technical feasibility, the three possible alternatives (i.e., image-guided thermal ablation, surgery, and active surveillance) were discussed with patients. Patients who agreed to be treated with image guided thermal ablation underwent radiofrequency (RFA) or la…

Malemedicine.medical_specialtyrecurrencecomplicationsRadiofrequency ablationEndocrinology Diabetes and Metabolismmedicine.medical_treatmentSedationThermal ablationPapillary Thyroid MicrocarcinomaThyroid function testslcsh:Diseases of the endocrine glands. Clinical endocrinology030218 nuclear medicine & medical imaginglaw.invention03 medical and health sciencesthermal ablation0302 clinical medicineEndocrinologylawmedicineHumansLocal anesthesiapapillary thyroid microcarcinomaThyroid NeoplasmsRetrospective StudiesOriginal Researchlcsh:RC648-665medicine.diagnostic_testbusiness.industryMicrowave ablationThyroidectomyMiddle AgedCarcinoma PapillarySurgeryTreatment OutcomeSurgery Computer-Assisted030220 oncology & carcinogenesisthyroidectomylaser ablationFemaleLaser Therapyradiofrequency ablationmedicine.symptombusinessFrontiers in Endocrinology
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Lobo Cabrera, Manuel: Doña Juana de Austria. La princesa gobernadora

2021

Manuel: Doña Juana de Austria. La princesa gobernadora Verdet MartínezUNESCO::HISTORIADoña Juana de Austria. La princesa gobernadora Verdet Martínez [Manuel]Revista de historia moderna 590302 2021 47 8168306 Lobo Cabrera [0210-9093 553 Estudis]Nuria 565 568:HISTORIA [UNESCO]0210-9093 553 Estudis: Revista de historia moderna 590302 2021 47 8168306 Lobo Cabrera
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L’inclusione vista dagli alunni: costruzione e validazione del questionario per rilevare la qualità inclusiva della scuola

2018

Molti studi nazionali e internazionali si sono concentrati sulla valutazione e sulla promozione della qualità inclusiva della scuola. Si tratta di un argomento complesso, che ha stimolato un ampio dibattito e una varietà di contributi che mettono in luce la necessità di uno strumento in grado di misurare la qualità inclusiva delle nostre scuole, per determinare l’evidenza empirica riguardo a questo tema. L’articolo presenta i risultati di una sperimentazione finalizzata alla redazione di un questionario per la rilevazione della qualità inclusiva del sistema scolastico percepita dagli alunni. Il questionario si pone come uno strumento di valutazione e autovalutazione che permette la misurazi…

Many national and international studies have concentrated on the evaluation and promotion of the inclusive qualities of schools. It is a complex issue which has led to wide debate and a variety of contributions which in turn highlight the need for a tool capable of measuring the inclusive quality of our schools in order to determine the empirical evidence regarding this topic. This article presents the results of an experiment in drafting a questionnaire in order to measure the inclusive quality of the school system perceived by its pupils. The questionnaire is intended as an evaluation and selfevaluation tool that enables the inclusive quality generated by the context to be measured as it is perceived by pupils. At the same time the tool allows reflection processes amongst teachers to be promoted so that they can implement educational activities which contribute to the planning and control of inclusive teaching practices. This contribution puts forward an original tool for measuring the inclusive quality of the school system perceived by pupils attending primary school in several Sicilian towns. It was administered in its definitive version to a sample of 1652 children. The psychometric properties of the tool and the significance it can hold in the areas of planning in research and of educational design are presented in this paper.Settore M-PED/03 - Didattica E Pedagogia Speciale
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Gozos a la beata Mariana de Jesus, de la Orden de nuestra Señora de la Merced, Redencion de Cautivos

1750

El full orlat Grav. xil. enmarcat de "La Bta. Mariana de Jesus", flanquejat per gerros amb flors Text del goig a tres col. separades per filets

Marianna de Jesús Beata (1565-1624) Goigs
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