Search results for "70"
showing 10 items of 9933 documents
Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules?
2021
Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should be objective and quantifiable and respond to specific therapeutic interventions. Optimal biomarkers should reflect the underlying process (pathological or not), be reproducible, widely available, and allow measurements repeatedly over time. Ideally, biomarkers should also be non-invasive and cost-effective. This review aims to focus on the usefulness and limitations of electroencephalography (EEG) in the search for Alzheimer’s disease (AD) biomarkers. The main aim of this article is to review the evolution of the most used biomarkers in AD and the need for new peripheral and, ideally, non-invasive b…
Drug-Coated Balloon vs. Stent for de novo Non-small Coronary Artery Disease: A Systematic Review and Meta-Analysis
2021
Introduction: Drug-coated balloon (DCB) has been an attractive option in de novo vessels. A systematic review and meta-analysis were conducted to evaluate the efficacy and safety of DCB vs. stent for treating de novo lesions in non-small vessels.Methods: Studies in PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science were searched (from their commencement to March 2021). This meta-analysis was performed by Review Manager 5.3.Results: A total of 3 random controlled trials (RCTs) with 255 patients and 2 observational studies (OS) with 265 patients were included in this meta-analysis following our inclusion criteria. It could be observed that DCB presented no …
Mellommenneskelige aspekter i operasjonsteamet -operasjonssykepleieres opplevelser : kvalitative intervju med operasjonssykepleiere om opp- levelser …
2014
Masteroppgave i spesialsykepleie – Universitetet i Agder 2014 Background: Experiences from practice in surgical units led us to question what makes teamwork effective and elegant, and also reflect upon the causes of situations where the teamwork is less than optimal and team members become frustrated. Purpose and research question: We based our research design on some of the relational factors defined in Reeves et al. (2010) conceptual framework for interprofessional teamwork. This was done to explore how surgical nurses experience these factors in relation to cooperation in surgical teams. We chose the following research question: How do surgical nurses experience the relational factors of…
Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex
2014
Highlights • We characterise Sas3p and Gcn5p active HAT complexes in WT and deleted TAP-strains. • We confirm that Pdp3p interacts with NuA3, histones and chromatin regulators. • Pdp3p MS-analysis reveals its phosphorylation, ubiquitination and methylation. • Sas3p can substitute Gcn5p in acetylation of histone H3K14 but not of H3K9. • Genome-wide profiling of Sas3p supports its involvement in transcriptional elongation.
On a nonlinear Schrödinger equation for nucleons in one space dimension
2021
We study a 1D nonlinear Schrödinger equation appearing in the description of a particle inside an atomic nucleus. For various nonlinearities, the ground states are discussed and given in explicit form. Their stability is studied numerically via the time evolution of perturbed ground states. In the time evolution of general localized initial data, they are shown to appear in the long time behaviour of certain cases.
Hva påvirker bruken av e-læring som læringsverktøy blant anestesisykepleiere
2014
Masteroppgave i spesialsykepleie – Universitetet i Agder 2014 Background: To ensure competence it is important to use good sources of knowledge and learning tools that provide good learning outcome. E-learning is considered to be the future focus to ensure a common updated competence. Purpose: Purpose of this study was to illuminate what influences the use of e-learning as a learning tool among nurse anesthetists. Methods: We conducted a cross-sectional study using a questionnaire based on the technology acceptance model (TAM). Based on previous theory and research, we added organizational factors to TAM. We performed a cross-sectional study among 369 nurse anesthetists in helse sør-øst. 11…
Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents
2022
Over the last decade, several compounds have been identified for the treatment of obesity. However, due to the complexity of the disease, many pharmacological interventions have raised concerns about their efficacy and safety. Therefore, it is important to discover new factors involved in the induction/progression of obesity. Adipose stromal/stem cells (ASCs), which are mostly isolated from subcutaneous adipose tissue, are the primary cells contributing to the expansion of fat mass. Like other cells, ASCs release nanoparticles known as extracellular vesicles (EVs), which are being actively studied for their potential applications in a variety of diseases. Here, we focused on the importance …
Interrelationship Between Age, Gender, and Weight Status on Motor Coordination in Italian Children and Early Adolescents Aged 6–13 Years Old
2021
Although numerous evidences reported a negative correlation between motor coordination (MC) and overweight/obesity in children and adolescents, the interrelationship between age, gender, and weight status is still debatable. Hence, the aim of this cross-sectional study was to examine the association between MC and weight status according to age and gender across childhood and early adolescence in a large sample of Italian elementary and middle school students. A number of 1961 Italian school students (1,026 boys, 935 girls) was stratified in three consecutive age groups (6–7, 8–10, and 11–13 years) and four weight status categories (underweight, normal weight, overweight, and obese) accordi…
Food policies to prevent obesity and the main non-transmissible diseases in Spain: where there's a will there's a way
2019
Introducción: En España, un tercio de los menores y dos tercios de los adultos padecen exceso de peso, una condición que genera un sobre coste médico directo de 2000 millones de euros. El entorno alimentario obesogénico causa obesidad al promover el consumo de bebidas azucaradas y de alimentos ultraprocesados. Por ello, proponemos cinco políticas prioritarias con el PODER de revertir la epidemia de obesidad y de enfermedades no transmisibles asociadas a ella, mediante la creación de entornos alimentarios saludables.El PODER de las políticas alimentarias: P (Publicidad): regulación de la publicidad de alimentos y bebidas no saludables dirigida a menores por todos los medios y prohibición de …
Adipokines in obesity and metabolic diseases
2020
Adipose tissue secretes many adipokines that regulate important physiological functions. Growing studies have highlighted that these bioactive molecules may contribute to the development of metabolic and cardiovascular diseases. Adipokines exert systemic metabolic effects and independent activity on numerous cells of the cardiovascular system, including cardiomyocytes and vascular cell walls. Adiponectin shows anti-inflammatory and anti-atherosclerotic activity on blood vessels. Conversely, resistin is endowed with pro-inflammatory effects and stimulates the proliferation of smooth muscle cells, thus promoting the development of atherosclerotic plaque. Leptin plays an important role in card…