Search results for "82"

Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors.

2021

Simple Summary The clinical efficacy of immunotherapies when treating cold tumors is still low, and different treatment combinations are needed when dealing with this challenging scenario. In this work, a middle-out strategy was followed to develop a model describing the antitumor efficacy of different immune-modulator combinations, including an antigen, a toll-like receptor-3 agonist, and an immune checkpoint inhibitor in mice treated with non-inflamed tumor cells. Our results support that clinical response requires antigen-presenting cell activation and also relies on the amount of CD8 T cells and tumor resistance mechanisms present. This mathematical model is a very useful platform to ev…

Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism

2012

N-methyl-D-aspartate (NMDA) receptors belong to a family of ionotropic glutamate receptors that contribute to the signal transmission in the central nervous system. NMDA receptors are heterotetramers that usually consist of two GluN1 and GluN2 monomers. The extracellular ligand-binding domain (LBD) of a monomer is comprised of discontinuous segments that form the functional domains D1 and D2. While the binding of a full agonist glycine to LBD of GluN1 is linked to cleft closure and subsequent ion-channel opening, partial agonists are known to activate the receptor only sub-maximally. Although the crystal structures of the LBD of related GluA2 receptor explain the mechanism for the partial a…

El monument al mestre Serrano a Sueca per Vicente Beltrán: entusiasme inicial, construcció i problemes legals

2018

Linguistica Lettica, Nr. 23

2015

Perdre le fil: labyrinthes de la littérature française moderne

2009

From the day when Theseus killed the Minotaur, the Maze turned into a form in search of meaning, and became useless. As a result, one was enjoined to ascribe nw meanings to the empty strcuture. Modern writers, when confronted with such a void, will have explored all its possibilities: while some of them, like Michel Butor, dismiss the sacred dimensions, others, like Serge Doubrovsky, see in it the image of the self (the body, the psyche...), and others still, like Raymond Roussel, Alain Robbe-Grillet or Georges Pererc, make of the pure geometrical structure of the labyrinth an aesthetic model, and thus a mirror of the work of art. However, one still have to ask whether the labrinth is a val…

No brihwestibas un wiņņas eezelschanas Kursemmē : Wisseem gohdigeem Kursemmes arrajeem par pamahzischanu un wajadsigu siņņu [No brīvestības un viņas …

1819

Tekstā arī “Dziesma uz Ķeizara Aleksandra dzimšanas dienu”, dziesma “No brīvestības”, Kurzemes arāja īsu lūgšana priekš dabūtās brīvestības

Supersymmetric structures for second order differential operators

2012

Necessary and sufficient conditions are obtained for a real semiclassical partial differential operator of order two to possess a supersymmetric structure. For the operator coming from a chain of oscillators, coupled to two heat baths, we show the non-existence of a smooth supersymmetric structure, for a suitable interaction potential, provided that the temperatures of the baths are different.

Studi greci e latini nell?antica Università di Altamura (1748-1821)

2019

The article tries to highlight, despite the scarse of available documentation, the Greek and Latin studies (language and texts) in the ancient Apulian University in Altamura (1748-1821). Furthermore, on the basis of unpublished archival materials (school registers and student workbooks) it is possible to shed light on the ancient authors explained at school, the teaching methods, and the study practices.

Inuentiones y translationes de S. Mercurio

2019

Inuentiones and translationes of the relics are part of the hagiographic dossier of a saint and provide interesting information about his cult over the centuries. For S. Mercurius of Caesarea the original texts in Greek have been lost, but we have two collections miracles in Coptic that narrate the inuentio and translatio of his relics and there is also a medieval tradition about his translatio to Benevento (Italy). From all these texts is deduced a healing cult of S. Mercurius based on the usual topics.

First record of the enigmatic coleoid genus Longibelus from Sakhalin (Far East Russia): a contribution to our understanding of Cretaceous coleoid hab…

2021

AbstractA newly collected specimen of the enigmatic coleoid genus Longibelus is recorded from lower Turonian strata along the River Shadrinka in Sakhalin (Russian Far East). To date, this is the first record of Late Cretaceous coleoid cephalopods from the island and, in fact, from the entire Pacific coast of the Russian Federation. Lithological characteristics, coupled with published geochemical analyses (δ13C and Corg content), suggest the habitat of this coleoid taxon to have been the middle to outer (i.e. distal) shelf. Its provenance from the stratigraphical level that is known as the Scaphites Event, characterised by a mass occurrence of Scaphites and Yesoites, may be indicative of occ…