Search results for "95"
showing 10 items of 2244 documents
Efficacy and safety of photodynamic therapy with RLP068 for diabetic foot ulcers: a review of the literature and clinical experience
2020
This article is the second part of a literature review concerning diabetic foot ulcers (DFUs) and the use of antimicrobial photodynamic therapy (PDT). PDT involves the topical application of a photosensitiser into the tissue, followed by illumination that induces the formation of reactive oxygen species (ROS). PDT provides bacterial inactivation and promotes wound healing, and it can be used to manage the infection and microbial colonisation of DFUs. It has pivotal advantages in comparison with chemotherapeutics, such as no potential to induce resistance, and a wide spectrum of activity. Tetracationic Zn(II) phthalocyanine derivatives have been developed for PDT. Among these, we would like …
Sulfonilurea preparātu farmakoģenētika cukura diabēta ārstēšanā
2015
Darba aktualitāte: Otrā tipa cukura diabēta (2TCD) prevalence pieaug gan Latvijas, gan pasaules mērogā. Pacientiem ir nepieciešama personalizēta pieeja, kas labāk ļautu sasniegt terapijas mērķi un izvairīties no komplikācijām. Sulfonilurea (SU) preparāti ir viena no visbiežāk izmantotajām perorālo antidiabētisko preparātu klasēm, tāpēc ir būtiski apzināt šo preparātu individuālos efektus. Pētījuma mērķis: Noskaidrot, vai SU preparātu farmakoģenētika ietekmē 2TCD pacientu ārstēšanas rezultātu. Metodes un materiāli: Longitudinālā prospektīvā pētījumā tika iesaistīti 315 2TCD pacienti, retrospektīvi tika iesaistīti 162, no kuriem kopumā sulfonilurea preparātus bija lietojuši 162, atlases kritē…
Polyphenols and Pharmacological Screening of a Monarda fistulosa L. dry Extract Based on a Hydrodistilled Residue By-Product
2021
This study aimed to determine the composition and content of polyphenols in the dry extract obtained from the hydrodistilled residue by-product of the wild bergamot (Monarda fistulosa L., Lamiaceae Martinov family) herb (MFDE) and to evaluate its safety and pharmacological properties. The total phenolic content (TPC) in the MFDE was 120.64 mg GAE/g. The high-performance liquid chromatography (HPLC) analysis showed the presence of a plethora of phenolic compounds, including hydroxycinnamic acids and flavone derivatives in the MFDE, with rosmarinic acid and luteolin-7-O-glucoside being the main components. With an IC50 value of 0.285 mg/mL, it was found to be a strong DPPH radical scavenger. …
The shape of the liquid plain: sicilian salt flats
2019
This paper analyzes the salt flats as a place for the mixing of knowledge and experiences that originate and substantiate life: from the application of physical, chemical and biological principles to produce salt, to economic laws to regulate sales and trade, to aspects socio-anthropological aspects underlying the life of the communities that worked in production. A patrimony of material and immaterial overlaps, generated by the redesign of a segment of territory with physical and positional characteristics median between sea and land, and in which man strives to obtain fundamental resources for his livelihood. Given the complex moment of crisis and gradual abandonment that these particular…
Rehellisyyteen kasvatetut miehet : 1920-1950-lukujen savottalaisten identiteetti, sosiaalistuminen ja muistot Ylä-Savossa
2010
Tutkin yläsavolaisten savottalaisten ammatti-identiteettiä ja heidän sosiaalistumistaan 1920−1950-luvuilla oman haastatteluaineistoni pohjalta. Haastateltavia oli 26. Tutkin, miten lapset ja nuoret, yleensä pojat, sosiaalistettiin savottayhteisöön kerronnan ja vanhempien antaman esimerkin avulla. Tutkin myös, millaiseksi savottalaisten ammatti-identiteetti kehittyi mm. sanktioiden avulla. Korpilaki oli sanktio, joka ohjasi yhteisön jäseniä. Koska suurin osa yläsavolaisista savottalaisista oli perheellisiä miehiä, jotka olivat hankkimassa rahaa perheensä käyttöön, heillä oli voimakas motiivi saada yhteisönsä toimimaan niin, että rahallinen tulo oli mahdollisimman suuri, työvälineitä tai tili…
Multi-Energy School System for Seasonal Use in the Mediterranean Area
2020
School buildings represent an energy-consuming sector of real estate where different efficiency actions are necessary. The literature shows how the design of a multi-energy system offers numerous advantages, however, there are problems related to the integration of cogeneration units with renewable energy sources due to the low flexibility of the first one and the high degree of uncertainty of the latter. The authors provide an alternative solution through the analysis of a case study consisting of a multiple energy system in three Sicilian schools, focusing on the system&rsquo
Russian-speaking immigrant teachers in Finnish classrooms : Views and lived experiences in Finnish education
2017
Success of integration depends, amongst other things, on immigrants’ involvement in the host country’s education. Educational differences between home and host countries can either promote or hinder academic progress of immigrants and, consequently, overall process of their integration. The goal of this study is to investigate what effect differences between educational systems of Finland and neighbouring Russia may have on professional induction of Russian-speaking immigrant teachers in Finland. This is done through researching experiences of Russian-speaking teachers in Finnish education. Their views and interpretations of their own eligibility and Finnish schooling practices lay foundati…
Are Public Subsidies to Encourage Young Farmers Effective? Case Study of a First-Time Farm Set Up by a Young Female Farmer in the Valencian Region of…
2021
Generational renewal and the incorporation of women into the rural world are fundamental for the sustainability and modernisation of the agricultural sector. Hence the special government protection granted to the sector, which appears in both European legislation on rural issues and in the global strategy of the 2030 Agenda and the Sustainable Rural Development Goals involving a commitment to measures aimed at helping young farmers to set up agricultural holdings and especially at encouraging women to engage in farm management. In the case of Spain, this is nothing new, given that Law 35/2011 on the Shared Ownership of Agricultural Holdings became a veritable revolution in terms of gender i…
Girls4STEM: Gender Diversity in STEM for a Sustainable Future
2020
Science, Technology, Engineering, and Mathematics (STEM) are key disciplines towards tackling the challenges related to the Sustainable Development Goals. However, evidence shows that women are enrolling in these disciplines in a smaller percentage than men, especially in Engineering related fields. As stated by the United Nations Women section, increasing the number of women studying and working in STEM fields is fundamental towards achieving better solutions to the global challenges, since the potential for innovation is larger. In this paper, we present the Girls4STEM project, which started in 2019 at the Escola Tè
Infrastructural and Human Factors Affecting Safety Outcomes of Cyclists
2018
The increasing number of registered road crashes involving cyclists during the last decade, and the high proportion of road crashes resulting in severe injuries and fatalities among cyclists constitutes a global issue for community health, urban development, and sustainability. Nowadays, the incidence of many risk factors for road crashes of cyclists remains largely unexplained. Given the importance of this issue, the present study has been conducted with the aim of determining relationships between infrastructural, human factors and safety outcomes of cyclists. Objectives: This study aimed, first, to examine the relationship between key infrastructural and human factors present in cycling,…