Search results for "A2"
showing 10 items of 1101 documents
TGF-β2 silencing to target biliary-derived liver diseases
2020
ObjectiveTGF-β2 (TGF-β, transforming growth factor beta), the less-investigated sibling of TGF-β1, is deregulated in rodent and human liver diseases. Former data from bile duct ligated and MDR2 knockout (KO) mouse models for human cholestatic liver disease suggested an involvement of TGF-β2 in biliary-derived liver diseases.DesignAs we also found upregulated TGFB2 in liver tissue of patients with primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), we now fathomed the positive prospects of targeting TGF-β2 in early stage biliary liver disease using the MDR2-KO mice. Specifically, the influence of TgfB2 silencing on the fibrotic and inflammatory niche was analysed on m…
Restoration of the Northeast cloister of the Convento de la Compañía de Jesús in Antigua, Guatemala
1998
[EN] The extraordinary history of the foundation, destruction and survival of La Antigua in Guatemala, a city frozen in time over two centuries ago, is the background for the introduction of the history of the Convento de la CompañÌa de Jesús and its northeast cloister, which has recently been restored and whose surrounding buildings have been refurbished to house the headquarters of the Institute of Ibero-American Cooperation in the city.
A construction of a fuzzy topology from a strong fuzzy metric
2016
<p>After the inception of the concept of a fuzzy metric by I. Kramosil and J. Michalek, and especially after its revision by A. George and G. Veeramani, the attention of many researches was attracted to the topology induced by a fuzzy metric. In most of the works devoted to this subject the resulting topology is an ordinary, that is a crisp one. Recently some researchers showed interest in the fuzzy-type topologies induced by fuzzy metrics. In particular, in the paper (J.J. Mi\~{n}ana, A. \v{S}ostak, {\it Fuzzifying topology induced by a strong fuzzy metric}, Fuzzy Sets and Systems, 6938 DOI information: 10.1016/j.fss.2015.11.005.) a fuzzifying topology ${\mathcal T}:2^X \to [0,1]$ …
Predicting the bioaccumulation of polyaromatic hydrocarbons and polychlorinated biphenyls in benthic animals in sediments
2016
There were two main objectives in this study. The first was to compare the accuracy of different prediction methods for the chemical concentrations of polyaromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) in the organism, based on the measured chemical concentrations existing in sediment dry matter or pore water. The predicted tissue concentrations were compared to the measured ones after 28-day laboratory test using oligochaeta worms (Lumbriculus variegatus). The second objective was to compare the bioaccumulation of PAHs and PCBs in the laboratory test with the in situ bioaccumulation of these compounds. Using the traditional organic carbon-water partitioning model, tissue…
New analysis of ηπ tensor resonances measured at the COMPASS experiment
2018
We present a new amplitude analysis of the $\eta\pi$ $D$-wave in $\pi^- p\to \eta\pi^- p$ measured by COMPASS. Employing an analytical model based on the principles of the relativistic $S$-matrix, we find two resonances that can be identified with the $a_2(1320)$ and the excited $a_2^\prime(1700)$, and perform a comprehensive analysis of their pole positions. For the mass and width of the $a_2$ we find $M=(1307 \pm 1 \pm 6)$~MeV and $\Gamma=(112 \pm 1 \pm 8)$~MeV, and for the excited state $a_2^\prime$ we obtain $M=(1720 \pm 10 \pm 60)$~MeV and $\Gamma=(280\pm 10 \pm 70)$~MeV, respectively.
Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery.
2014
AbstractNucleotides activating P2Y13 receptors display neuroprotective actions against different apoptotic stimuli in cerebellar granule neurons. In the present study, P2Y13 neuroprotection was analyzed in conditions of genotoxic stress. Exposure to cisplatin and UV radiation induced caspase-3-dependent apoptotic cell death, and p38 MAPK signaling de-regulation. Pre-treatment with P2Y13 nucleotide agonist, 2methyl-thio-ADP (2MeSADP), restored granule neuron survival and prevented p38 long-lasting activation induced by cytotoxic treatments. Microarray gene expression analysis in 2MeSADP-stimulated cells revealed over-representation of genes related to protein phosphatase activity. Among them…
Dental stem cell signaling pathway activation in response to hydraulic calcium silicate-based endodontic cements: A systematic review of in vitro stu…
2020
Abstract Objective To present a qualitative synthesis of in vitro studies which analyzed human dental stem cell (DSC) molecular signaling pathway activation in response to hydraulic calcium silicate-based cements (HCSCs). Methods A systematic electronic search was performed in Medline, Scopus, Embase, Web of Science and SciELO databases on January 20 and last updated on March 20, 2020. In vitro studies assessing the implication of signaling pathways in activity related marker (gene/protein) expression and mineralization induced by HCSCs in contact with human DSCs were included. Results The search identified 277 preliminary results. After discarding duplicates, and screening of titles, abstr…
Simulation of PLL with impulse signals in MATLAB: Limitations, hidden oscillations, and pull-in range
2015
The limitations of PLL simulation are demonstrated on an example of phase-locked loop with triangular phase detector characteristic. It is shown that simulation in MatLab may not reveal periodic oscillations (e.g. such as hidden oscillations) and thus may lead to unreliable conclusions on the width of pull-in range.
Coordination networks incorporating halogen-bond donor sites and azobenzene groups
2016
Two Zn coordination networks, {[Zn(1)(Py)2]2(2-propanol)}n (3) and {[Zn(1)2(Bipy)2](DMF)2}n (4), incorporating halogen-bond (XB) donor sites and azobenzene groups have been synthesized and fully characterized. Obtaining 3 and 4 confirms that it is possible to use a ligand wherein its coordination bond acceptor sites and XB donor sites are on the same molecular scaffold (i.e., an aromatic ring) without interfering with each other. We demonstrate that XBs play a fundamental role in the architectures and properties of the obtained coordination networks. In 3, XBs promote the formation of 2D supramolecular layers, which, by overlapping each other, allow the incorporation of 2-propanol as a gues…
Anti-Inflammatory Triterpenes from Pistacia terebinthus Galls
2002
From the galls of Pistacia terebinthus we obtained an extract that proved to be effective against chronic and acute inflammation. Now we report on the isolation and identification of three triterpenes: two tirucallane-type lanostanoids and one oleanane, which we have identified as masticadienonic acid (1), masticadienolic acid (2), and morolic acid (3), respectively. All of them showed effectiveness on the mouse ear inflammation induced by repeated applications of 12-O-tetradecanoylphorbol 13-acetate and on the phospholipase A2-induced foot paw edema. The pharmacological activity of the compounds was ratified by a histological study of the ear samples. In addition, they inhibited leukotrien…