6533b7d4fe1ef96bd1262a10
RESEARCH PRODUCT
Anti-Inflammatory Triterpenes from Pistacia terebinthus Galls
Rosa M. GinerJose M. PrietoEva M Giner-larzaM. Carmen RecioJosé Luis RíosSalvador MáñezMiguel Cerdá-nicolássubject
Magnetic Resonance SpectroscopyNeutrophilsmedicine.drug_classLeukotriene B4Anti-Inflammatory AgentsCyproheptadinePharmaceutical SciencePharmacologyPharmacognosyLeukotriene B4Pistacia terebinthusDexamethasonePhospholipases AAnti-inflammatoryAnalytical ChemistryMicechemistry.chemical_compoundPhospholipase A2TriterpeneDrug DiscoverymedicineAnimalsOleananeCalcimycinInflammationPharmacologychemistry.chemical_classificationDose-Response Relationship DrugIonophoresbiologyPistaciaPlant ExtractsOrganic Chemistrybiology.organism_classificationTriterpenesHindlimbPhospholipases A2Complementary and alternative medicinechemistryBiochemistryPistaciabiology.proteinTetradecanoylphorbol AcetateMolecular Medicinedescription
From the galls of Pistacia terebinthus we obtained an extract that proved to be effective against chronic and acute inflammation. Now we report on the isolation and identification of three triterpenes: two tirucallane-type lanostanoids and one oleanane, which we have identified as masticadienonic acid (1), masticadienolic acid (2), and morolic acid (3), respectively. All of them showed effectiveness on the mouse ear inflammation induced by repeated applications of 12-O-tetradecanoylphorbol 13-acetate and on the phospholipase A2-induced foot paw edema. The pharmacological activity of the compounds was ratified by a histological study of the ear samples. In addition, they inhibited leukotriene B4 production in rat polymorphonuclear leukocytes stimulated with calcium ionophore A 23187.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-05-04 | Planta Medica |