Search results for "A2"
showing 10 items of 1101 documents
Propagation Channels for mmWave Vehicular Communications : State-of-the-art and Future Research Directions
2018
Vehicular communications essentially support automotive applications for safety and infotainment. For this reason, industry leaders envision an enhanced role for vehicular communications in the fifth generation of mobile communications technology. Over the years, the number of vehicle- mounted sensors has increased steadily, which potentially leads to more volume of critical data communications in a short time. Also, emerging applications such as remote/autonomous driving and infotainment such as high-definition movie streaming require data-rates on the order of multiple Gb/s. Such high data rates require a large system bandwidth, but very limited bandwidth is available in the sub-6 GHz cel…
Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.
2000
The melanosomal protein tyrosinase is considered as a target of specific immunotherapy against melanoma. Two tyrosinase-derived peptides are presented in association with HLA-A2.1 [Wolfel et al., Eur. J. Immunol., 24, 759-764 (1994)]. Peptide 1-9 (MLLAVLYCL) is generated from the putative signal sequence. The internal peptide 369-377 is posttranslationally converted at residue 371, and its presentation is dependent on functional TAP transporters and proteasomes [Mosse et al., J. exp. Med.187, 37-48 (1998)]. Herein, we report on the processing and transport requirements for the signal sequence-derived peptide 1-9 that were studied in parallel to those for peptide 369-377. After infection of …
The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multipl…
2020
The IL22RA2 locus is associated with risk for multiple sclerosis (MS) but causative variants are yet to be determined. In a single nucleotide polymorphism (SNP) screen of this locus in a Basque population, rs28385692, a rare coding variant substituting Leu for Pro at position 16 emerged significantly (p = 0.02). This variant is located in the signal peptide (SP) shared by the three secreted protein isoforms produced by IL22RA2 (IL-22 binding protein-1(IL-22BPi1), IL-22BPi2 and IL-22BPi3). Genotyping was extended to a Europe-wide case-control dataset and yielded high significance in the full dataset (p = 3.17 ×
Effect of macro and micro nutrients addition during anaerobic mono-digestion of grass silage in leach-bed reactors
2019
The effect of macro- (NH4Cl) (set I) and micro-nutrients (Fe, Ni, Co and Mo) (set II) addition on chemical oxygen demand (COD) solubilisation during anaerobic mono-digestion of grass silage was investigated in two sets of leach bed reactor experiments at 35°C. Results showed that addition of NH4Cl and micro-nutrients improved COD solubilisation by 18% (0.56 g SCOD g−1 volatile solids) and 7% (0.45 g SCOD g−1 VS), respectively than control. About 20–50% of the added micro-nutrients were bioavailable in the produced leachates, while the rest (50–80%) were adsorbed onto the grass silage. Results of biological methane potential assays showed that, specific methane yields of grass silage were im…
Parvovirus H-1-Induced Tumor Cell Death Enhances Human Immune Response In Vitro via Increased Phagocytosis, Maturation, and Cross-Presentation by Den…
2005
Oncotropic and oncolytic viruses have attracted high attention as antitumor agents because they preferentially kill cancer cells in vitro and reduce the incidence of spontaneous, induced, or implanted animal tumors. Some autonomous parvoviruses (H-1, minute virus of mice) and derived recombinant vectors are currently under preclinical evaluation. Still not fully understood, their antitumor properties involve more than just tumor cell killing. Because wild-type parvovirus-mediated tumor cell lysates (TCLs) may trigger antigen-presenting cells (APCs) to augment the host immune repertoire, we analyzed phagocytosis, maturation, and crosspresentation of H-1-induced TCLs by human dendritic cells …
Neformālo izglītības metožu izmantošana sociāli emocionālās mācīšanās prasmju pilnveidei sociālo zinību stundās 7. klasēm
2022
Neformālās izglītības metodes arvien vairāk tiek izmantotas formālajā izglītības processā. Skolotāji tās sāk izmantot dažādos stundas procesos, lai veicinātu skolēnu sociāli emocionālo prasmju attīstību. Vienlaikus jāakcentē, ka Skola2030 vadlīnijas saskan ar neformālās izglītības metožu principiem. Savā diplomdarbā darba autors vēlējās izpētīt kā neformālās izglītības metožu izmantošana pilnveido 7.klašu skolēnu sociāli emocionālās mācīšanās prasmes? Diplomdarba autors izstrādāja divas anketas, lai novērtētu skolēnu izpratni par savām sociāli emocionālajām mācīšanās prasmēm, kā arī veica pedagoģiskās novērošanas stundu ietvaros. Diplomdarba nosaukums ir ’’Neformālo izglītības metožu izmant…
Projektu veida uzdevumi skolēnu radošuma veicināšanai 11. klases angļu valodas stundās
2022
Šis darbs pēta radošuma konceptu un to, kā tas var tikt iekļauts projektveida uzdevumos 11. klašu skolēniem. Lai gan radošums nav minēta kā atsevišķa caurviju prasme Latvijas izglītības standartā Skola2030, pēc šī darba autores domām, liela daļa tajā definēto sasniedzamo mācīšanās rezultātu nav iespējams sasniegt bez radošas domāšanas. Tāpēc, šī darba mērķis bija izpētīt zinātnisko literatūru par radošumu, analizēt Skola2030 prasības svešvalodai vidusskolā pēc to radošuma potenciāla, izveidot projekta darba uzdevumu divām 11. klašu grupām un to ieviest praksē. Šis darbs dod ieskatu radošuma teorētiskajos konceptos, kā arī sniedz idejas projekta darbu ieviešanai angļu valodas kā svešvalodas …
Skolas gaitu uzsākšana 6 gadu vecumā izaicinājumi/ izvērtējums
2019
Šī darba mērķis ir teorētiski un praktiski izvērtēt sešgadīgu bērna gatavību uzsākt mācības skolā, balstoties uz šī vecuma bērnu raksturojumu, mūsdienu skolas vidi un mācību saturu. Lai sasniegtu minēto mērķi tika apskatīts un izanalizēts plašs teorētiskais materiāls. Kvalifikācijas darbs ietver mūsdienu bērnu, jaunās mācību vides un mācību procesa, jēdzienu “adaptācija” un “gatavs skolai” izvērtējums. Kā arī tika izpētīts bērna psihiskās un personības attīstības raksturojums. Tika veikts pētījums par ārvalstu pieredzi. Darba autore veica pētījumu, kur izvērtēja 18 bērnu sagatavotību skolai. Tika aptaujātas vecāku domas par skolas gaitu uzsākšanu 6 gados. Pētījuma hipotēze apstiprināsies, t…
Implementation of preventive and predictive BRCA testing in patients with breast, ovarian, pancreatic, and prostate cancer: a position paper of Itali…
2022
Constitutional BRCA1/BRCA2 pathogenic or likely pathogenic variants (PVs) are associated with an increased risk for developing breast and ovarian cancers. Current evidence indicates that BRCA1/2 PVs are also associated with pancreatic cancer, and that BRCA2 PVs are associated with prostate cancer risk. The identification of carriers of constitutional PVs in the BRCA1/2 genes allows the implementation of individual and family prevention pathways, through validated screening programs and risk-reducing strategies. According to the relevant and increasing therapeutic predictive implications, the inclusion of BRCA testing in the routine management of patients with breast, ovarian, pancreatic and…
CCDC 2023411: Experimental Crystal Structure Determination
2020
Related Article: Braulio Michele Puerta Lombardi, Chris Gendy, Benjamin S. Gelfand, Guy M. Bernard, Roderick E. Wasylishen, Heikki M. Tuononen, Roland Roesler|2021|Angew.Chem.,Int.Ed.|60|7077|doi:10.1002/anie.202011301