Search results for "A2"
showing 10 items of 1101 documents
Alterazioni funzionali leucocitarie nella malattia ipertensiva
2009
Tribological properties of thin films made by atomic layer deposition sliding against silicon
2018
Interfacial phenomena, such as adhesion, friction, and wear, can dominate the performance and reliability of microelectromechanical (MEMS) devices. Here, thin films made by atomic layer deposition (ALD) were tested for their tribological properties. Tribological tests were carried out with silicon counterpart sliding against ALD thin films in order to simulate the contacts occurring in the MEMS devices. The counterpart was sliding in a linear reciprocating motion against the ALD films with the total sliding distances of 5 and 20 m. Al2O3 and TiO2 coatings with different deposition temperatures were investigated in addition to Al2O3-TiO2-nanolaminate, TiN, NbN, TiAlCN, a-C:H [diamondlike car…
Ekstracelulārās kalcija koncentrācijas ietekme uz krūts vēža šūnu līnijas MCF-7 migrāciju un invāziju
2018
Visbiežākais ar krūts vēzi saistītais nāves iemesls ir metastāzes citos orgānos. Lai metastāzes veidotos, šūnām ir jābūt spējīgām migrēt un invadēt. Tomēr pētījumu rezultāti par ekstracelulārā Ca2+ ietekmi uz krūts vēža šūnu spēju migrēt un invadēt ir pretrunīgi. Darba mērķis bija noteikt ekstracelulārā Ca2+ koncentrācijas ietekmi uz krūts vēža šūnu līnijas MCF-7 migrāciju un invāziju. Šūnas tika kultivētas barotnēs ar dažādu Ca2+ koncentrāciju. Tika konstatēts, ka palielināta ekstracelulārā Ca2+ koncentrācija barotnē samazina MCF-7 šūnu spēju migrēt un invadēt, bet neietekmē populācijas dubultošanās laiku. Šūnās, kas kultivētas barotnēs ar palielinātu Ca2+ koncentrāciju, ciešo starpšūnu ko…
Choosing an A2-language and language education from teachers’ point of view
2015
Language education policy consists of multiple levels, all the way from the European Union to teachers in local schools. Bearing in mind that even teachers have a role to play in language education policy our bachelor’s thesis aimed to create an overall picture of what knowledge do primary school teachers and headmasters in the Jyväskylä area possess relating language education matters and more specifically the A2-language. The study also examined the situations in which the teachers would or would not recommend the A2-language to a pupil. How the teachers act in the process of choosing the A2-language was also the focus of this study. This article affords a glance to our research and its r…
A methodological framework based on a DANP model for evaluating the software quality in terms of usability: a preliminary investigation on mobile ope…
2020
Evaluation of the software usability as concerns software alternatives represents a typical Multi- Criteria Decision-Analysis (MCDA) problem. Such a kind of problem can be successfully faced via structured models and approaches which validity have been widely shown in literature. In this work, a methodological framework based on a MCDA model integrating the DEMATEL method along with the ANP technique is proposed and explained with more detail to address the relevant issue of the software usability evaluation. The applicability of the considered DEMATEL-ANP (DANP) based model in the under analysis contest is demonstrated via a preliminary investigation, where the usability of the two major M…
Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications
2018
Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) antibodies. There is sound evidence that aPL act as pathogenic autoantibodies being responsible for vascular clots and miscarriages. However, the exact mechanisms involved in the clinical manifestations of the syndrome are still a matter of investigation. In particular, while vascular thrombosis is apparently not associated with inflammation, the pathogenesis of miscarriages can be explained only in part by the aPL-mediated hypercoagulable state and additional non-thrombotic effects, including placental inflammation, have b…
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2.
2015
The NG2 proteoglycan is characteristically expressed by oligodendrocyte progenitor cells (OPC) and also by aggressive brain tumours highly resistant to chemo- and radiation therapy. Oligodendrocyte-lineage cells are particularly sensitive to stress resulting in cell death in white matter after hypoxic or ischemic insults of premature infants and destruction of OPC in some types of Multiple Sclerosis lesions. Here we show that the NG2 proteoglycan binds OMI/HtrA2, a mitochondrial serine protease which is released from damaged mitochondria into the cytosol in response to stress. In the cytosol, OMI/HtrA2 initiates apoptosis by proteolytic degradation of anti-apoptotic factors. OPC in which NG…
Design and Culture of the Territory: Ecomuseo del Grano e del Pane in the Salemi Museum System
2019
The article deals with design experimentation in the complex and composite field of design for the culture of the territory, aimed at enhancing the particular resources common to the Mediterranean areas, through an incremental and collaborative design methodology. The town of Salemi (TP) inherited an extraordinary concentration of cultural heritage from its history; in particular the preparation and display of the decorated breads for the Festivity of San Giuseppe, occurring on March 19th, which expresses a profound religiosity and a complex rituality, shared, handed down and recognized as an intan- gible cultural asset to be protected. In this territorial context, a vision aimed at encour-…
On the limit velocity and buckling phenomena of axially moving orthotropic membranes and plates
2011
In this paper, we consider the static stability problems of axially moving orthotropic membranes and plates. The study is motivated by paper production processes, as paper has a fiber structure which can be described as orthotropic on the macroscopic level. The moving web is modeled as an axially moving orthotropic plate. The original dynamic plate problem is reduced to a two-dimensional spectral problem for static stability analysis, and solved using analytical techniques. As a result, the minimal eigenvalue and the corresponding buckling mode are found. It is observed that the buckling mode has a shape localized in the regions close to the free boundaries. The localization effect is demon…
Literatūra kā palīglīdzeklis franču valodas apguvē iesācēju līmenim
2020
Jau sākot ar iesācēju līmeņiem (A1, A2, A2+) franču valodas kā svešvalodas apguvē ir ieteicams iekļaut literāros tekstus. Šāda prakse atver skolēniem durvis uz citu kultūru, bagātina viņu valodu, veicina intelekta attīstību un parāda skaistumu, ko sniedz fantāziju pasaule. Darba mērķis ir noteikt kritērijus pēc kādiem izvēlēties literāros darbus, lai tie būtu piemēroti iesācēju līmenim (A1, A2, A2+) franču valodā kā svešvalodā kā arī metodes kā no šiem darbiem izveidot aktivitātes franču valodas pasniegšanai iesācēju līmenim. Lai šos kritērijus noteiktu tika apskatīti dažādi speciālistu viedokļi, kā arī izpētītas piedāvātās metodes darbu iekļaušanai mācību procesā saglabājot to oriģinalitāt…