Search results for "AAT"
showing 10 items of 6105 documents
Hellisonin vastuuntuntoisuuden mallin kokeilu seitsemännen luokan poikien liikuntatunneilla
2002
The human liver fatty acid binding protein (FABP1) gene is activated by FOXA1 and PPARα; and repressed by C/EBPα: Implications in FABP1 down-regulati…
2013
Liver fatty acid binding protein (FABP1) prevents lipotoxicity of free fatty acids and regulates fatty acid trafficking and partition. Our objective is to investigate the transcription factors controlling the human FABP1 gene and their regulation in nonalcoholic fatty liver disease (NAFLD). Adenovirus-mediated expression of multiple transcription factors in HepG2 cells and cultured human hepatocytes demonstrated that FOXA1 and PPARα are among the most effective activators of human FABP1, whereas C/EBPα is a major dominant repressor. Moreover, FOXA1 and PPARα induced re-distribution of FABP1 protein and increased cytoplasmic expression. Reporter assays demonstrated that the major basal activ…
CCAAT/Enhancer-binding Protein α (C/EBPα) and Hepatocyte Nuclear Factor 4α (HNF4α) Synergistically Cooperate with Constitutive Androstane Receptor to…
2010
The transcription of tissue-specific and inducible genes is usually subject to the dynamic control of multiple activators. Dedifferentiated hepatic cell lines lose the expression of tissue-specific activators and many characteristic hepatic genes, such as drug-metabolizing cytochrome P450. Here we demonstrate that by combining adenoviral vectors for CCAAT/enhancer-binding protein α (C/EBPα), hepatocyte nuclear factor 4α (HNF4α), and constitutive androstane receptor, the CYP2B6 expression and inducibility by CITCO are restored in human hepatoma HepG2 cells at levels similar to those in cultured human hepatocytes. Moreover, several other phase I and II genes are simultaneously activated, whic…
A heuristic model-based approach for compensating wind effects in ski jumping.
2021
Wind influences the jump length in ski jumping, which raises questions about the fairness. To counteract the wind problem, the International Ski Federation has introduced a wind compensation system in 2009: time-averaged wind velocity components tangential to the landing slope are obtained from several sites along the landing slope, and these data are used in a linear statistical model for estimating the jump length effect of wind. This is considered in the total score of the ski jump. However, it has been shown that the jump length effect estimates can be inaccurate and misleading. The present manuscript introduces an alternative mathematical wind compensation approach that is based on an …
The 1-loop effective potential for the Standard Model in curved spacetime
2018
The renormalisation group improved Standard Model effective potential in an arbitrary curved spacetime is computed to one loop order in perturbation theory. The loop corrections are computed in the ultraviolet limit, which makes them independent of the choice of the vacuum state and allows the derivation of the complete set of $\beta$-functions. The potential depends on the spacetime curvature through the direct non-minimal Higgs-curvature coupling, curvature contributions to the loop diagrams, and through the curvature dependence of the renormalisation scale. Together, these lead to significant curvature dependence, which needs to be taken into account in cosmological applications, which i…
Massless positivity in graviton exchange
2021
We formulate Positivity Bounds for scattering amplitudes including exchange of massless particles. We generalize the standard construction through dispersion relations to include the presence of a branch cut along the real axis in the complex plane for the Maldestam variable $s$. In general, validity of these bounds require the cancellation of divergences in the forward limit of the amplitude, proportional to $t^{-1}$ and $\log(t)$. We show that this is possible in the case of gravitons if one assumes a Regge behavior of the amplitude at high energies below the Planck scale, as previously suggested in the literature, and that the concrete UV behaviour of the amplitude is uniquely determined…
Space and Time Averaged Quantum Stress Tensor Fluctuations
2021
We extend previous work on the numerical diagonalization of quantum stress tensor operators in the Minkowski vacuum state, which considered operators averaged in a finite time interval, to operators averaged in a finite spacetime region. Since real experiments occur over finite volumes and durations, physically meaningful fluctuations may be obtained from stress tensor operators averaged by compactly supported sampling functions in space and time. The direct diagonalization, via a Bogoliubov transformation, gives the eigenvalues and the probabilities of measuring those eigenvalues in the vacuum state, from which the underlying probability distribution can be constructed. For the normal-orde…
Design Features for Gender-specific Differences in Blended Learning within Higher Education in Indonesia
2019
Blended learning offers learning solutions for higher educational institutions facing the industrial revolution 4.0. In this study, we investigated the influence factors student perceptions of blended learning based on gender-specific differences in Indonesia. We applied a research model to systematically assess the effect of design features on the effectiveness of blended learning indicators (intrinsic motivation and student satisfaction). Moreover, we evaluated the research model for both genders separately. Based on the quantitative survey of 223 Indonesian students, our study confirms that the design features significantly influence the effectiveness of blended learning for male and fem…
Let the best story win : evaluation of the most cited business history articles
2017
Faced with intensifying competition for scientific impact measured in terms of citation counts, small disciplines are challenged to prove their importance as they lack the critical mass to accumulate large numbers of citations. This paper demonstrates that by emphasizing theoretical and methodological rigor even small disciplines such as business history can be competitive. Yet it still appears that readers of business history articles first and foremost seek interesting and useful subject matter, i.e. ‘best’ stories that can be used as background information and as tools in comparisons. However, articles advancing theory and methodology have increasingly gained interest and citations from …
Research on international trade and transport : a generational shift?
2018
Scandinavian economic historians made a strong presence at the World Economic History Congress (WEHC), Boston, this summer. Around one hundred Nordic scholars featured on the list of participants, ...