Search results for "ADHERENCE"

Antithrombotische Therapie bei peripherer arterieller Verschlusskrankheit

2018

Was ist neu? Antithrombotische Therapie bei stabiler PAVK Die aktuellen deutschen und europäischen Leitlinien empfehlen bei Patienten mit einer peripheren arteriellen Verschlusskrankheit (PAVK) die Monotherapie mit einem Thrombozytenaggregationshemmer (ASS 100 mg oder Clopidogrel 75 mg).In der COMPASS (Cardiovascular OutcoMes for People using Anticoagulation StrategieS) -Studie wurde Patienten mit PAVK 2 × 2,5 mg Rivaroxaban zusätzlich zu ASS 100 mg gegeben. Dies führte zur signifikanten Reduktion kardiovaskulärer Ereignisse (MACE = Major Adverse Cardiovascular Events) wie kardiovaskulärer Tod, Myokardinfarkt und Schlaganfall. Ebenfalls signifikant reduziert wurden periphere Ereignisse (MAL…

Periphere arterielle Verschlusskrankheit als Zusatzdiagnose bei koronarer Herzerkrankung – Einfluss auf Diagnostik, Therapie und Prognose

2014

Das Vorliegen einer PAVK verschlechtert die Prognose eines Patienten mit KHK und sollte daher bei Diagnostik und Therapieplanung berucksichtigt werden. Ist eine weiterfuhrende Diagnostik bei V. a. eine KHK geplant, sollte man an mogliche Limitationen durch das Vorliegen einer PAVK denken. Bei einer Ergometrie sind PAVK Patienten moglicherweise aufgrund einer Claudicatio weniger gut belastbar, bei einer invasiven Diagnostik konnen Probleme beim Gefaszugang auftreten. Die Einstellung der kardiovaskularen Risikofaktoren ist bei allen Manifestationen der Arteriosklerose wichtig. Herbei sind die Empfehlungen der Leitlinien bei PAVK und KHK vergleichbar. Ebenso sind Thrombozytenaggregationshemmer…

Fostering drug.storage,preparation and treatment modalities improves adherence to treatment with turoctocog-alfa in patients with haemophilia A:resul…

2019

Overcoming barriers to evidence-based patient blood management: a restricted review

2020

Abstract Background Blood transfusions are associated with a range of adverse patient outcomes, including coagulopathy, immunomodulation and haemolysis, which increase the risk of morbidity and mortality. Consideration of these risks and potential benefits are necessary when deciding to transfuse. Patient blood management (PBM) guidelines exist to assist in clinical decision-making, but they are underutilised. Exploration of barriers to the implementation and utilisation of the PBM guidelines is required. This study aimed to identify common barriers and implementation strategies used to implement PBM guidelines, with a comparison against current expert opinion. Methods A restricted review a…

Combined Point of Care Tools Are Able to Improve Treatment Adherence and Health-Related Quality of Life in Patients with Severe Hemophilia: An Observ…

2019

Introduction: Ultrasound (US) assessment of joints is an evolving point of care tool for the detection of early joint arthropathy (Napolitano M, Kessler CM. Hemophilia A and B. Consultative Hemostasis and Thrombosis, Kitchens, 4th edition); population pharmacokinetic (pop-PK) studies are adopted as a useful instrument to set the prophylaxis regimen for patients with hemophilia, they may improve adherence (Nagao A.et al. Thromb Res. 2019 Jan; 173:79-84) and reduce the annual bleeding rate (ABR). Adherence to continuous intravenous administrations of factor VIII or Factor IX products is challenging, thus patients may experience breakthrough bleedings while on prophylaxis. Repeated US examinat…

Patterns and determinants of adherence to resistance and endurance training during cancer treatment in the Phys-Can RCT.

2022

Abstract Background Knowledge regarding adherence is necessary to improve the specificity of exercise interventions during cancer treatment. We aimed to determine adherence to resistance and endurance training interventions in parallel; identify subgroups with similar adherence characteristics; and examine determinants of these subgroups. Methods In the Phys-Can randomised controlled trial, participants (n = 577, 81% women, mean(SD) age 59(12) years, and 50% with BMI ≥ 25 kg/m2) starting (neo-) adjuvant treatment for breast, colorectal or prostate cancer were randomized to 6-month of high (HI) or low-to-moderate intensity (LMI) supervised, group-based resistance training and individual home…

Noninfectious uveitis: strategies to optimize treatment compliance and adherence.

2015

Noninfectious uveitis includes a heterogenous group of sight-threatening ocular and systemic disorders. Significant progress has been made in the treatment of noninfectious uveitis in recent years, particularly with regard to the effective use of corticosteroids and non-corticosteroid immunosuppressive drugs, including biologic agents. All of these therapeutic approaches are limited, however, by any given patient's ability to comply with and adhere to their prescribed treatment. In fact, compliance and adherence are among the most important patient-related determinants of treatment success. We discuss strategies to optimize compliance and adherence.

Latvijas Ģimenes hiperholesterinēmijas reģistra pacientu līdzestība rekomendētajai lipīdus pazeminošai terapijai

2021

Ģimenes hiperholesterinēmija (ĢH) ir ģenētiska autosomāli dominantā ceļā pārmantojama slimība, kas būtiski ietekmē zema blīvuma lipoproteīnu holesterīna (ZBLH) katabolismu un paaugstina KSS risku, apmēram 20 reizes. Hipolipidemizējošā terapija būtiski samazina kardiovaskulāru notikumu risku pacientiem ar ĢH, tomēr neskatoties uz vadlīniju rekomendācijām un efektīvu terapiju pieejamības, daudzi pacienti nesasniedz savus lipīdu mērķus un viņiem joprojām ir augsts kardiovaskulārais risks. Līdz ar to ir būtiski jāizvērtē arī pacientu līdzestības faktors. Pētījuma mērķis: Noskaidrot Latvijas Ģimenes hiperholesterinēmijas reģistra (LĢHR) pacientu līdzestību rekomendētajai hipolipidemizējošai tera…

COMPLEMENT-DEPENDENT B-CELL ACTIVATION BY COBRA VENOM FACTOR AND OTHER MITOGENS?

1974

It has been proposed that two distinct signals are required for the triggering of the precursors of antibody-forming bone marrow-derived cells (B cells): (a) the binding of antigen or of a mitogen to the corresponding receptor sites on B-cell membranes and (b) the interaction of activated C3 with the C3 receptor of B lymphocytes. There is growing evidence that B-cell mitogens and T (thymus-derived cell)-independent antigens are capable of activating the alternate pathway of the complement system (bypass). Therefore, the effect of another potent bypass inducer was investigated with regard to B-cell activation and the role of C3. Purified, pyrogen-free cobra venom factor was mitogenic for bot…

Real-world effectiveness of long acting aripiprazole: Treatment persistence and its correlates in the Italian clinical practice

2019

Abstract Objectives To identify the variables that are associated with persistence to Aripiprazole-Long Acting (A-LAI), in adult patients with schizophrenia. Methods Observational, retrospective, non-interventional study involving 261 patients with schizophrenia. Results Eighty-six percent of study subjects were persistent for at least 6 months. All subjects with baseline CGI-S of 1 or 2, 95% of subjects with CGI-S of 3, 86% with CGI-S of 4, 82% of subjects with CGI-S of 5, 73% of subjects with CGI of 6 and 90% of subjects with CGI of 7 were persistent. A-LAI treatment continuation rate was higher in patients with: 1) baseline CGI score ≤ 4; 2) schizophrenia dimension (LDPS) mania score ≤ 5…