Search results for "AEM"
showing 10 items of 1006 documents
High-level secretion of tumor necrosis factor-alpha contributes to hematopoietic failure in hairy cell leukemia [see comments]
1989
Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in vitro colony assays. As potent producers of TNF-alpha, hairy cells could be identified, thus implicating the malignant population in the pathogenesis of hematopoietic failure due to inappropriate secretion of this cytokine.
High-level secretion of tumor necrosis factor-alpha contributes to hematopoietic failure in hairy cell leukemia [see comments]
1989
Abstract Hairy cell leukemia (HCL) is frequently associated with severe pancytopenia. The authors detected high levels of tumor necrosis factor (TNF)-alpha in the bone marrow serum of patients with HCL and found anti-TNF-alpha neutralizing monoclonal antibodies (MoAbs) to be able to enhance hematopoiesis of HCL patients in in vitro colony assays. As potent producers of TNF-alpha, hairy cells could be identified, thus implicating the malignant population in the pathogenesis of hematopoietic failure due to inappropriate secretion of this cytokine.
Liderazgo transformacional e intraemprendedurismo. Una relación mediada por la cultura organizacional
2015
El estudio está orientado al análisis de la relación entre el liderazgo transformacional (LT) y el intraemprendedurismo (IE) y la mediación de la cultura organizacional(CO) en dicha relación. Se lleva a cabo con base en una muestra de 400 profesionales. Los instrumentos utilizados fueron para el liderazgo transformacional el diseñado por Podsakoff, MacKenzie, Moorman y Fetter (1990) y Podsakoff, MacKenzie y Bommer (1996); para el intraemprendedurismo el instrumento desarrollado por Mora y Siles (2012) y para la cultura organizacional el instrumento elaborado por Denison y Mishra (1995), adaptado a Costa Rica por Vargas (2013). El análisis de datos se se realiza con el uso de análisis multiv…
The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror
2021
Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent chronic metabolic disorders, and insulin has been placed at the epicentre of its pathophysiological basis. However, the involvement of impaired alpha (α) cell function has been recognized as playing an essential role in several diseases, since hyperglucagonemia has been evidenced in both Type 1 and T2DM. This phenomenon has been attributed to intra-islet defects, like modifications in pancreatic α cell mass or dysfunction in glucagon’s secretion. Emerging evidence has shown that chronic hyperglycaemia provokes changes in the Langerhans’ islets cytoarchitecture, including α cell hyperplasia, pancreatic beta (β) cell dedifferentiati…
Endokrinologische Vorhersage der Therapieansprechbarkeit depressiver Patienten auf Lofepramin
1979
In a pilot study of 15 depressive patients of the neurotic and endogenous type we could show that some neuroendocrinological parameters are apt to predict the thymoleptic efficacy of lofepramine. These parameters, which were measured with a simple global stimulation test (insulin hypoglycaemia combined with injection of TRH and LHRH), were as follows: high basal blood glucose; high hypoglycaemic blood glucose; high decrease of blood glucose in comparison to the basal level; low basal TSH; low increase of HGH and low increase of cortisol after hypoglycemia. A synopsis of these parameters allowed a correct classification of 14 out of 15 patients according to therapy response and therapy resis…
Standardization of sampling and staining methods for the morphometric evaluation of sperm heads in the Cynomolgus monkey (Macaca fascicularis) using …
2005
Automated sperm morphology analysis (ASMA) technology has improved the assessment of sperm morphology, but the results depend on the use of adequate and standardized procedures. In this study the Sperm-Class Analyzer® (SCA) ASMA system was used to assess sperm head morphometry in the Cynomolgus monkey and to evaluate the influence of sample size, intraslide variation, and the use of three staining techniques on the accuracy of image processing and sperm head morphometry. Haematoxylin is the staining technique of choice for Cynomolgus spermatozoa, as optimum contrast of sperm heads with the surrounding background allows efficient segmentation, i.e. sperm head boundary detection, making the i…
Intenciones de emprendimiento e intraemprendimiento de los estudiantes universitarios de ciencias del deporte: un enfoque multicultural
2019
Debido a la crisis económica acaecida en los últimos años a nivel mundial, las tasas de desempleo juvenil han aumentado, lo que ha generado que el interés de las universidades por el fomento de la actividad emprendedora entre los jóvenes universitarios se haya incrementado. Fruto de ello, es que el estudio de las intenciones de emprender con estudiantes universitarios ha ganado atención durante los últimos años, aunque no ha sucedido lo mismo con las intenciones de intraemprendimiento, pese a la importancia que este tipo de emprendimiento conlleva para el rendimiento y la competitividad de las empresas ya existentes. Sin embargo, estos estudios se han centrado principalmente en estudiantes …
Anaphylaxie nach gleichzeitiger Impfung gegen Masern, Mumps, Röteln und Frühsommer-Meningoenzephalitis aufgrund einer Gelatineallergie
2006
Most allergic reactions after vaccination occur in patients sensitive to egg protein. Therefore this subject is well investigated, and the majority of common vaccines today contain only traces of egg protein. In contrast, there is little knowledge of hypersensitivities to other substances frequently contained in vaccines, e. g. antibiotics, phenol, gelatin and different preservatives. Here we report the case of a boy who had an anaphylactic reaction after being vaccinated against measles, mumps, rubella (MMR), and tick-born encephalitis (TBE) simultaneously. Different tests finally revealed a hypersensitivity to gelatin. This should be kept in mind especially during emergency care, since ge…
Cecal trap: CT findings of isolated cecal necrosis
2016
Learning objectives Background Findings and procedure details Conclusion Personal information References
CD3 immunohistochemistry is helpful in the diagnosis of giant cell arteritis.
2018
Objective. To evaluate whether CD3 staining performed routinely on temporal artery biopsy specimens might improve the sensitivity of temporal artery biopsy in patients with biopsy-negative GCA. Methods. Two hundred and seventy biopsies were considered for this study, stained with haematoxylin and eosin and with an anti-CD3 antibody. Results. The addition of CD3 staining modified the sensibility and the specificity of the histologic examination in 89.47 and 95.00%, respectively, with a positive and negative predictive values of 97.00 and 79.78%. Conclusion. The addition of CD3 immunostaining to the classic histologic evaluation is accompanied by a significant increase in the sensibility with…