Search results for "AEP"

Chromoendoscopy in Inflammatory Bowel Disease

2012

Chromoendoscopy with methylene blue or indigo carmine significantly increases the diagnostic yield of finding intraepithelial neoplasia in patients with longstanding colitis. The number needed to treat is 14 for panchromoendoscopy to identify 1 additional patient with dysplasia. Chromoendoscopy can greatly facilitate the identification of flat lesions harboring intraepithelial neoplasia. Chromoendoscopy can guide biopsies and clearly reduces the amount of biopsies that are needed per patient. Magnifying endoscopy or CLE are additional techniques, which can be used in conjunction with chromoendoscopy to further reduce the amount of biopsies and to further increase the diagnostic yield. Chrom…

Qui Exsitum Parentes Dederunt : a formulation in prose of the immatura (praepostera) mors topos on a roman inscription in ager Tarraconensis (Renau, …

2016

Mediante un análisis gráfico y lingüístico y examinando la tradición de la epigrafía latina sepulcral, la frase con la que concluye esta inscripción, y que no pertenece al formulario habitual de la epigrafía en prosa, se interpreta como una formulación del tópico de la immatura (praepostera) mors Not only the graphic and linguistic analysis, but also the typical tradition in Latin sepulchral inscriptions, suggest that the final sentence, which does not belong to the usual form epigraphy prose, should be interpreted as a formulation of the immatura (praepostera) mors topos

The Transcription Factors TBX2 and TBX3 Interact with Human Papillomavirus 16 (HPV16) L2 and Repress the Long Control Region of HPVs

2013

ABSTRACT The minor capsid protein L2 of human papillomaviruses (HPVs) has multiple functions during the viral life cycle. Although L2 is required for effective invasion and morphogenesis, only a few cellular interaction partners are known so far. Using yeast two-hybrid screening, we identified the transcription factor TBX2 as a novel interaction partner of HPV type 16 (HPV16) L2. Coimmunoprecipitations and immunofluorescence analyses confirmed the L2-TBX2 interaction and revealed that L2 also interacts with TBX3, another member of the T-box family. Transcription of the early genes during HPV infection is under the control of an upstream enhancer and early promoter region, the long control r…

How to develop strategies of adaptation to climate change based on a foresight exercise?

2019

Context and purpose of the study ‐ Prospective studies raise a real intellectual interest for those who contribute to them or take cognizance of it. But they are often considered too difficult to operationalize, and most of the prospective exercises are not followed by action plans, particularly at value chain level. To overcome this difficulty in linking the work of experts and the decisions of stakeholder of value chains, a particular effort was made to operationalize the outcomes from a prospective study on the French vine and wine industry in the context of climate change. The approach consisted in collecting and using the feed‐back of professionalsfrom the wine industry about these out…

Chromoscopy-Guided Endomicroscopy Increases the Diagnostic Yield of Intraepithelial Neoplasia in Ulcerative Colitis

2007

Background & Aims: Because of the large number of biopsy specimens, surveillance colonoscopy in ulcerative colitis (UC) is currently time consuming and significant flat lesions still may be missed. In this study we assessed the value of combined chromoscopy and endomicroscopy for the diagnosis of intraepithelial neoplasias in a randomized controlled trial. Methods: A total of 161 patients with long-term UC in clinical remission were randomized at a 1:1 ratio to undergo conventional colonoscopy or chromoscopy with endomicroscopy. Eight patients were excluded because of insufficient bowel preparation. In the conventional colonoscopic group (n = 73), random biopsy examinations and targeted bio…

Oppiminen ja asiantuntijuus varhaiskasvatuksessa : varhaisen oppimaan ohjaamisen suunnitelma erityistä tukea tarvitsevien lasten ohjauksessa

2004

Vulvar cancer: a review for dermatologists.

2015

Vulvar malignancies are important tumors of the female reproductive system. They represent a serious health issue with an incidence between 2 and 7 per 100,000 and year. We provide a review about most important cancer entities, i.e., melanoma, squamous cell carcinoma, basal cell carcinoma, neuroendocrine cancer, and skin adnexal malignancies. Squamous cell carcinoma is the most common vulvar malignancy that can develop from vulvar intraepithelial neoplasia or de novo. Basal cell carcinoma represents only 2 % of all vulvar cancers. Melanoma of the vulva exists in two major types—superficial spreading and acral lentiginous. A special feature is the occurrence of multiple vulvar melanomas. Of …

Indicators of agricultural intensity and intensification: a review of the literature

2015

Since the 1960s, research has dealt with agricultural intensification (AI) as a solution to ensure global food security. Recently, sustainable intensification (SI) has increasingly been used to describe those agricultural and farming systems that ensure adequate ecosystem service provision. Studies differ in terms of the application scales and methodologies, thus we aim to summarize the main findings from the literature on how AI and SI are assessed, from the farm to global levels. Our literature review is based on 7865 papers selected from the Web of Science database and analysed using CorText software. A further selection of 105 relevant papers was used for an in-depth full-text analysis …

IL-10 signaling prevents gluten-dependent intraepithelial CD4(+) cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine

2019

Breach of tolerance to gluten leads to the chronic small intestinal enteropathy celiac disease. A key event in celiac disease development is gluten-dependent infiltration of activated cytotoxic intraepithelial lymphocytes (IELs), which cytolyze epithelial cells causing crypt hyperplasia and villous atrophy. The mechanisms leading to gluten-dependent small intestinal IEL infiltration and activation remain elusive. We have demonstrated that under homeostatic conditions in mice, gluten drives the differentiation of anti-inflammatory T cells producing large amounts of the immunosuppressive cytokine interleukin-10 (IL-10). Here we addressed whether this dominant IL-10 axis prevents gluten-depend…

Leptin: A pivotal mediator of intestinal inflammation in mice

2002

Abstract Background & Aims: In addition to acting as a regulator of food intake and energy expenditure, leptin can also modulate immune and inflammatory responses. The role of leptin in intestinal inflammation is the focus of the present study. Methods: Acute and chronic colitis were induced in leptin-deficient ob/ob or wild-type (WT) mice using dextran sulfate sodium (DSS) or trinitrobenzene sulfonic acid (TNBS). The severity of colitis was evaluated, and possible mechanisms were studied. Results: Leptin directly stimulates intraepithelial lymphocytes (IELs) and lamina propria mononuclear cells (LPMCs). In the DSS acute model, ob/ob mice exhibited a 72% reduction of colitis severity and sp…