Search results for "AIH"
showing 10 items of 785 documents
Peak oxygen uptake cut-points to identify children at increased cardiometabolic risk - The PANIC Study.
2019
We aimed to develop cut -points for directly measured peak oxygen uptake (VO2peak ) to identify boys and girls at increased cardiometabolic risk using different scaling methods to control for body size and composition. Altogether 352 children (186 boys, 166 girls) aged 9 – 11 years were included in the analyses. We measured VO2peak directly during a maximal cycle ergometer exercise test and lean body mass (LM) by bioelectrical impedance. We computed a sex - and age -specific cardiometabolic risk score (CRS) by summing important cardiometabolic risk factors and defined increased cardiometabolic risk as >1 standard deviation above the mean of CRS. Receiver operating characteristics curves wer…
Assessment of students’ agency in Finnish and Spanish university courses: Analysis of measurement invariance
2023
This study reports on the measurement invariance of the Agency of University Students Scale in data consisting of Finnish and Spanish university students (n = 645) and presents cross-national findings on student agency assessment. Multigroup confirmatory factor analysis confirmed the metric invariance for 10 factors, which allows comparisons of covariance structures and correlation analyses, and can, for example, be used to examine background factor effects on agency across groups. At least partial scalar invariance was confirmed for six factors, allowing comparisons of mean values between Finnish and Spanish students. Differences were found in the experiences of personal and relational res…
Muscle Free Fatty-Acid Uptake Associates to Mechanical Efficiency During Exercise in Humans
2018
Intrinsic factors related to muscle metabolism may explain the differences in mechanical efficiency (ME) during exercise. Therefore, this study aimed to investigate the relationship between muscle metabolism and ME. Totally 17 healthy recreationally active male participants were recruited and divided into efficient (EF; n = 8) and inefficient (IE; n = 9) groups, which were matched for age (mean ± SD 24 ± 2 vs. 23 ± 2 years), BMI (23 ± 1 vs. 23 ± 2 kg m−2), physical activity levels (3.4 ± 1.0 vs. 4.1 ± 1.0 sessions/week), and V˙O2peak (53 ± 3 vs. 52 ± 3 mL kg−1 min−1), respectively, but differed for ME at 45% of V˙O2peak intensity during submaximal bicycle ergometer test (EF 20.5 ± 3.5 vs. I…
Effect of Chronic Exercise Training on Blood Lactate Metabolism Among Patients With Type 2 Diabetes Mellitus : A Systematic Review and Meta-Analysis
2021
Purpose: To assess the effect of chronic exercise training on blood lactate metabolism at rest (i.e., basal lactate concentrations) and during exercise (i.e., blood lactate concentration at a fixed load, load at a fixed blood lactate concentration, and load at the individual blood lactate threshold) among patients with type 2 diabetes mellitus (T2DM).Methods: PubMed (MedLine), Embase, Web of Science, and Scopus were searched. Randomized controlled trials, non-randomized controlled trials, and case-control studies using chronic exercise training (i.e., 4 weeks) and that assessed blood lactate concentrations at rest and during exercise in T2DM patients were included.Results: Thirteen studies …
Influence of Menstrual Cycle or Hormonal Contraceptive Phase on Energy Intake and Metabolic Hormones—A Pilot Study
2021
Sex hormones are suggested to influence energy intake (EI) and metabolic hormones. This study investigated the influence of menstrual cycle (MC) and hormonal contraceptive (HC) cycle phases on EI, energy availability (EA), and metabolic hormones in recreational athletes (eumenorrheic, NHC = 15 and monophasic HC-users, CHC = 9). In addition, 72-h dietary and training logs were collected in addition to blood samples, which were analyzed for 17β-estradiol (E2), progesterone (P4), leptin, total ghrelin, insulin, and tri-iodothyronine (T3). Measurements were completed at four time-points (phases): Bleeding, mid-follicular (FP)/active 1, ovulation (OVU)/active 2, mid-luteal (LP)/inactive in NHC/C…
Vascular Adhesion Protein 1 Mediates Gut Microbial Flagellin-Induced Inflammation, Leukocyte Infiltration, and Hepatic Steatosis
2021
Toll-like receptor 5 ligand, flagellin, and vascular adhesion protein 1 (VAP-1) are involved in non-alcoholic fatty liver disease. This study aimed to determine whether VAP-1 mediates flagellin-induced hepatic fat accumulation. The effects of flagellin on adipocyte VAP-1 expression were first studied in vitro. Then, flagellin (100 ng/mouse) or saline was intraperitoneally injected into C57BL/6J (WT) and C57BL/6-Aoc3-/- (VAP-1 KO) mice on a high-fat diet twice a week every 2 weeks for 10 weeks. After that, the effects on inflammation, insulin signaling, and metabolism were studied in liver and adipose tissues. Hepatic fat was quantified histologically and biochemically. Because flagellin cha…
Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adipo…
2015
The loss of estrogen during menopause causes changes in the female body, with wide-ranging effects on health. Estrogen-containing hormone replacement therapy (HRT) leads to a relief of typical menopausal symptoms, benefits bone and muscle health, and is associated with tissue-specific gene expression profiles. As gene expression is controlled by epigenetic factors (including DNA methylation), many of which are environmentally sensitive, it is plausible that at least part of the HRT-associated gene expression is due to changes in DNA methylation profile. We investigated genome-wide DNA methylation and gene expression patterns of white blood cells (WBCs) and their associations with body compo…
Branched-Chain Amino Acid Deprivation Decreases Lipid Oxidation and Lipogenesis in C2C12 Myotubes
2022
Impaired lipid metabolism is a common risk factor underlying several metabolic diseases such as metabolic syndrome and type 2 diabetes. Branched-chain amino acids (BCAAs) that include valine, leucine and isoleucine have been proven to share a role in lipid metabolism and hence in maintaining metabolic health. We have previously introduced a hypothesis suggesting that BCAA degradation mechanistically connects to lipid oxidation and storage in skeletal muscle. To test our hypothesis, the present study examined the effects of BCAA deprivation and supplementation on lipid oxidation, lipogenesis and lipid droplet characteristics in murine C2C12 myotubes. In addition, the role of myotube contract…
Dietary intake and strength training adaptation in 50-70 -year old men and women : with special reference to muscle mass, strength, serum anabolic ho…
2007
Frailty has been defined as an age-related decrease of the physiologic systems that results in weakness, weight loss and decreased functional performance, thus increasing the risk of disability. The physical characteristics of frailty are affected by the amount of muscle mass and strength. Strength training (ST) can alleviate age-related declines in muscle mass, strength and physical function. However, there is controversy regarding whether dietary intake can improve the effects of ST. The present thesis assessed the effects of dietary intake (DI) on muscular, hormonal and metabolic adaptations to ST in healthy 50-70 year old people. In cross-sectional study I, maximal strength of the leg e…
Nikkelin kertyminen täplärapuun (Pacifastacus leniusculus) kahdessa eri lämpötilassa
2017
Kaivostoiminnan aiheuttamat metallipäästöt ovat maailmanlaajuinen ympäristöongelma. Kaivospäästöjen takia metalleja pääsee luontoon ja eliöstöön biosaatavassa vesiliukoisessa muodossa kuten sulfaatteina tai klorideina. Nikkeli on bioakkumuloituva eliöille haitallinen metalli, jota käytetään teollisuuden raaka-aineena ympäri maailmaa. Tässä tutkielmassa tarkasteltiin nikkelin kertymistä täplärapuun (Pacifastacus leniusculus) laboratorio-olosuhteissa kahdella 14 vrk:n altistuskokeella eri nikkelialtistuspitoisuuksilla kahdessa eri lämpötilassa (7 ja 17 °C). Eri testilämpötiloilla pyrittiin selvittämään, onko nikkelin kertyminen riippuvaista vaihtolämpöisen täpläravun aineenvaihduntatasosta. K…