Search results for "ALBI"
showing 10 items of 440 documents
The Albian (Vraconnian)-Cenomanian boundary at the western Tethyan margins (Central Tunisia and southeastern France).
2008
AbstractThrough the description and interpretation of the position of macro- and microfossils in several sections of the Albian-Cenomanian boundary in SE France and Central Tunisia, a comparison is made between the north and south margins of the Tethyan Ocean by using the occurrences of marker bioevents. For the planktonic foraminifera, the criterions applicable for the accurate determination of Thalmanninella globotruncanoides (Sigal) – the marker species for the base of the Cenomanian stage – are discussed. The species Th. globotruncanoides and the intermediate forms with its ancestor Th. caroni (Ion) are illustrated. For the ammonites, two subjects are new. Firstly, the species Stoliczka…
MARIOLA: a model for calculating the response of mediterranean bush ecosystem to climatic variations
1995
Abstract The paper summarizes the bush ecosystem model developed for assessing the effects of climatic change on the behaviour of mediterranean bushes assuming that temperature, humidity and rain-fall are the basic dimensions of the niche occupied by shrub species. In this context, changes in the monthly weather pattern serve only to outline the growth conditions due to the nonlinearity of response of shrubs to climatic factors. The plant-soil-atmosphere system is described by means of ordinary non-linear differential equations for the state variables: green biomass, woody biomass, the residues of green and woody biomasses, faecal detritus of mammals on the soil, and the total organic matte…
Zonation by ammonites and foraminifers of the Vraconnian-Turonian interval: A comparison of the Boreal and Tethyan domains (NW Europe / Central Tunis…
2008
International audience; Since the end of the 19th century the interval comprising the uppermost Upper Albian, the Cenomamian, the Turonian and the basal Coniacian has been subdivided, first into ammonite zones, then, beginning in the middle of the 20th century, into zones of planktonic foraminifera. These two groups, one macrofossil, the other microfossil, are particularly effective for bio-chronostratigraphy thanks to their rapid rates of evolution. But differences in the faunal makeup between the Boreal domain (northwestern Europe) and the Tethyan domain (Mediterranean) have for a long time hindered precise correlation of the two domains. Today, in a time interval covering about 16 millio…
Inhibition of the dimorphic transition of Candida albicans by the ornithine decarboxylase inhibitor 1,4-diaminobutanone: alterations in the glycoprot…
1990
Hyphal development in Candida albicans was selectively blocked by the ornithine decarboxylase competitive inhibitor 1,4-diaminobutanone (DAB). Inhibition of hyphal development required DAB during both yeast inoculum growth and subsequent incubation at 37 degrees C to induce mycelial growth. This effect was not due to general growth inhibition since DAB did not inhibit yeast growth, and reduced protein synthesis by 30% at most. Moreover, protein synthesis was unaffected by DAB when cells were pre-grown in drug-containing media. Since DAB inhibited dimorphic transition at 37 degrees C, morphology- and temperature-dependent protein synthesis could be distinguished. DAB stimulated the synthesis…
Colorimetric susceptibility testing for Aspergillus fumigatus: comparison of menadione-augmented 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazo…
1996
Two colorimetric methods that use Alamar Blue or 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) for assaying the in vitro activities of antifungal agents have been described. We report that both tests performed similarly when the antifungal activity of amphotericin B against Candida albicans was determined. However, only the MTT test generated interpretable data when Aspergillus fumigatus was used.
Voriconazole inhibits biofilm formation in different species of the genus Candida
2012
To determine the ability of voriconazole to inhibit the formation of biofilms.A total of 38 blood isolates of Candida spp. (8 Candida albicans, 10 Candida tropicalis, 10 Candida glabrata, 7 Candida parapsilosis sensu stricto and 3 Candida orthopsilosis) and C. albicans ATCC 90028 and ATCC 64548 were assessed. Biofilm formation was quantified using XTT reduction assays. The inhibition of biofilm formation was determined (i) in the presence of 0.06 and 0.25 mg/L voriconazole, and (ii) on surfaces previously coated with 0.06, 0.25, 1, 4 and 16 mg/L voriconazole.Voriconazole reduced biofilm formation under both conditions, the extent depending on the species, isolate and drug concentration. In …
Candida and Candidiasis: The Cell Wall as a Potential Molecular Target for Antifungal Therapy
2004
The fungal species Candida albicans is an opportunistic pathogen, which causes serious infections in humans, particularly in immunocompromised patients. Depending on the underlying host defect, C. albicans causes a variety of infections, ranging from superficial mucocutaneous candidiasis to life-threatening disseminated infections. Both the limited spectrum of antifungal drugs currently in clinical use and the emergence of resistances make necessary the development of new effective antifungal drugs with minimal side effects; however, such a research is limited by the small number of specific target sites identified to date. The cell wall is a fungal specific dynamic structure essential to a…
In vitro activity of the new semi-synthetic polypeptide cilofungin (LY121019) against Aspergillus and Candida species.
1990
The in vitro activity of cilofungin (LY121019), a new semi-synthetic antifungal agent was evaluated. Potent activity was seen against Candida albicans and Candida tropicalis, with almost identical MIC and MFC results, whereas no activity was seen against any isolates of Candida parapsilosis or three Aspergillus spp. However, MICs were dependent on medium and test conditions chosen. It is concluded that cilofungin has good activity against some medically important yeasts in vitro, and that its in vitro activity depends on the method used.
Serologic Response to Cell Wall Mannoproteins and Proteins of Candida albicans
1998
SUMMARY The cell wall of Candida albicans not only is the structure in which many biological functions essential for the fungal cells reside but also is a significant source of candidal antigens. The major cell wall components that elicit a response from the host immune system are proteins and glycoproteins, the latter being predominantly mannoproteins. Both the carbohydrate and protein moieties are able to trigger immune responses. Although cell-mediated immunity is often considered to be the most important line of defense against candidiasis, cell wall protein and glycoprotein components also elicit a potent humoral response from the host that may include some protective antibodies. Prot…
Antibody response toCandida albicanscell wall antigens
2003
The cell wall of Candida albicans is not only the structure where many essential biological functions reside but is also a significant source of candidal antigens. The major cell wall components that elicit a response from the host immune system are proteins and glycoproteins, the latter being predominantly mannoproteins. Both carbohydrate and protein moieties are able to trigger immune responses. Proteins and glycoproteins exposed at the most external layers of the wall structure are involved in several types of interactions of fungal cells with the exocellular environment. Thus, coating of fungal cells with host antibodies has the potential to profoundly influence the host-parasite intera…