Search results for "ALK"
showing 10 items of 4314 documents
Viltus atmiņas, alkohola lietošanas biežuma un uztvertā stresa saistības
2019
Bakalaura darba nosaukums ir “Viltus atmiņas, alkohola lietošanas biežuma un uztvertā stresa saistības”. Pētījuma mērķis bija noskaidrot, vai viltus atmiņas un uztvertais stress būs augstāks tiem indivīdiem, kuri biežāk lieto alkoholu. Pētījumā piedalījās 81 respondents, no kuriem 25 bija vīrieši un 56 bija sievietes. Respondentu vecums bija no 19 gadiem līdz 49 gadiem, vidējais vecums bija 26 gadi. Pētījumā tika izmantota depresijas, trauksmes un stresa skalas (Depression Anxiety Stress Scales, 1995). Latvijā metodi adaptējuši Edmunds Vanags un Malgožata Raščevska, 2015. Kā arī, tika izmantots viltus atmiņu tests (Vaska, Vanags, & Ekmanis, 2018), kurš tika izveidots kursa II vajadzībām, un…
Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine.
2011
International audience; Vinblastine and vincristine are dimeric indole alkaloids derived from (formerly: ). Their monomeric precursor molecules are vindoline and catharanthine. While vinblastine and vincristine are well-known mitotic spindle poisons, not much is known about vindoline and catharanthine. Vindoline and catharanthine showed weak cytotoxicity, while vinblastine, vincristine, and the semisynthetic vindesine and vinorelbine revealed high cytotoxicity towards cancer cells. This may reflect a general biological principle of poisonous plants. Highly toxic compounds are not only active towards predators, but also towards plant tissues. Hence, plants need mechanisms to protect themselv…
Synthesis of vinca alkaloids and related compounds LX. A simple transformation of apovincamine into vincamine
1992
Abstract The 15α-chloro-vincamine derivative 2 was prepared and proved to be key intermediate of a two-step transformation of apovincamine into vincamine. The structure of 2 was established via detailed NMR and X-ray investigations.
Copper-catalyzed regioselective synthesis of (E)-β-fluorovinyl sulfones
2019
Organofluorine compounds are finding increasing application in a variety of fields such as pharmaceutical, agrochemical, and material sciences. However, given the scarcity of fluorine-containing natural products, advancement in this area depends almost entirely on the development of new synthetic methodologies. In this article, we present the synthesis of a series of previously undescribed (E)-&beta
La violenza indicibile. l'aggressività femminile nelle relazioni interpersonali
2012
L’espressione della violenza nelle relazioni familiari è da alcuni anni oggetto di interesse in ambito sociologico, psicologico e giuridico. Le riflessioni teoriche e gli studi empirici sul tema hanno dato ampio spazio prevalentemente all’esercizio di violenza da parte dell’uomo lasciando sullo sfondo altre tipologie di relazioni disfunzionali ove la violenza viene invece perpetrata dalla donna. L'aggressività femminile è, invece, tutt'altro che rara, e se esiste un generale consenso sul fatto che gli uomini mostrino livelli più elevati di aggressione fisica rispetto alle donne, è pur vero che le differenze risultano essere piccole e moderate, evidenziando che anche le donne possono essere …
Parent-Implemented Hanen Program It Takes Two to Talk®: An Exploratory Study in Spain
2021
Parent-implemented interventions are a highly common approach for enhancing communication and linguistic abilities of late talkers, involving a population that shows a small expressive vocabulary in the absence of other deficits that could explain it. This study aimed to compare the outcomes of a parent-implemented language intervention, It Takes Two to Talk®—The Hanen Program® for Parents (ITTT), to a clinician-directed therapy. Participants were 17 families and their late-talking children: 10 families took part in ITTT and 7 in the clinician-directed modality. The outcomes in the social communication domain were more favorable for the ITTT group, but there were no significant differences …
Adaptive Vocabulary Learning Environment for Late Talkers
2016
The main aim of this research is to provide children who have an early language delay with an adaptive way to train their vocabulary taking into account individuality of the learner. The suggested system is a mobile game-based learning environment which provides simple tasks where the learner chooses a picture that corresponds to a played back sound from multiple pictures presented on the screen. Our basic assumption is that the more similar the concepts (in our case, words) are, the harder the recognition task is. The system chooses the pictures to be presented on the screen by calculating the distances between the concepts in different dimensions. The distances are considered to consist o…
Tilan väkeä ja naapureita : varhaismodernin maaseutuyhteisön sosiaalinen kenttä ja kontaktinmuodostus Vuorimäen tilalla 1807-1883
2011
Tutkimuksen aiheena on maaseutuyhteisön sosiaalinen kenttä ja kontaktinmuodostus, jota tutkin kummi-, avioliitto- ja palkolliskontaktien kautta. Tutkimuskohteena on keskisuomalainen Vuorimäen tila vuosina 1807–1883. Tutkimuksessa käytän yhteisöelämänkerrallista tutkimusotetta, jonka avulla saadaan koottua pienistä yksittäisiä ihmisiä käsittelevistä tiedon rippeistä laaja kuva koko yhteisöstä ja sen rakenteista ja mentaliteeteista. Tärkeä tutkimusmetodi on ollut myös sosiaalisten kenttien luominen, jossa olen soveltanut Juhani U.E. Lehtosen avioliittokenttä mallia ja kartallistamista. Keskeisinä lähteinä käytän rippi- ja historiakirjoja, joiden avulla olen selvittänyt tilan asukkaiden avioli…