Search results for "ALTER"
showing 10 items of 2368 documents
Secoiridoids and Iridoids from Morinda asteroscepa
2020
The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4–7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identified using NMR spectroscopic and mass spectrometric techniques, with the absolute configuration of 1 having been established by single-crystal X-ray diffraction analysis. The crude leaf extract (10 μg/mL) and compounds 1–3 and 5 (10 μM) showed mild antiplasmodial activities against the chloroquine-sensitive malaria parasite Plasmodium falciparum (…
Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells
2015
Abstract Background Apoptosis and other forms of cell death have been intensively investigated in the past years to explain the mode of action of synthetic anticancer drugs and natural products. Recently, a new form of cell death emerged, which was termed ferroptosis, because it depends on intracellular iron. Here, the role of genes involved in iron metabolism and homeostasis for the cytotoxicity of ten artemisinin derivatives have been systematically investigated. Material and methods Log10IC50 values of 10 artemisinin derivatives (artesunate, artemether, arteether, artenimol, artemisitene, arteanuin B, another monomeric artemisinin derivative and three artemisinin dimer molecules) were co…
What is new for an old molecule? : Systematic review and recommendations on the use of resveratrol
2011
BackgroundResveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark.MethodologyLiterature search in databases as PUBMED and ISI Web of Science in combination with manual search was used to answer the following five questions: (1)Can resveratrol be recommended in the prevention…
Evaluation of innovative thermal insulation systems for a sustainable envelope
2017
La memoria presenta i risultati ottenuti su sistemi di isolamento termico per l’involucro edilizio. Si presentano i risultati ottenuti tramite simulazioni informatiche che hanno consentito di verificare e ottimizzare la trasmissione del calore attraverso un sistema sottovuoto in vetro per le facciate trasparenti. Inoltre la possibilità offerta dal riciclo del materiale di scarto della potatura dell’Opunthia Ficus Indica (fichi d’india) che,opportunamente trattato ha permesso di ottenere un materiale isolante (Brevetto n. 1402131), in forma di pannello o in grani sfusi, (valori di coibenza termica 0.0710.057 W/mK). The paper presents the results of the research on thermal insulation systems…
Priming for JA-dependent defenses using hexanoic acid is an effective mechanism to protect Arabidopsis against B. cinerea
2011
Abstract Soil drench treatments with hexanoic acid can effectively protect Arabidopsis plants against Botrytis cinerea through a mechanism based on a stronger and faster accumulation of JA-dependent defenses. Plants impaired in ethylene, salicylic acid, abscisic acid or glutathion pathways showed intact protection by hexanoic acid upon B. cinerea infection. Accordingly, no significant changes in the SA marker gene PR-1 in either the SA or ABA hormone balance were observed in the infected and treated plants. In contrast, the JA signaling pathway showed dramatic changes after hexanoic acid treatment, mainly when the pathogen was present. The impaired JA mutants, jin1-2 and jar1 , were unable …
Per una fotografia alternativa. Scrittura e immagine in "Un settimo uomo" di John Berger e Jean Mohr
2016
Con il presente contributo si intendono indagare le modalità rappresentative di un dispositivo culturale che si situa all'incrocio tra storytelling, saggistica e immagine fotografica, dando luogo a una forma di comunicazione ibrida. Si esplora a tal fine il rapporto che lega testi e immagini in "Un settimo uomo di J. Berger, prodotto culturale arricchito e accompagnato dalle immagini dei migranti est-europei di J. Mohr.
Las ADR en la justicia del siglo XXI, en especial la mediación (The Alternative Dispute Resolution ‘ADR’ in the Justice of the 21st Century, Especial…
2011
Spanish Abstract: El presente ensayo busca exponer en torno a experiencias poco analizadas por los sistemas juridicos europeos de corte continental, pero muy bien conocidas por los sistemas anglosajones. El objetivo trazado es fomentar el debate en torno a estas alternativas para la resolucion de los conflictos en la sociedad, con especial atencion a la mediacion. English Abstract: This is essay seeks to expose not very much analyzed experiences by the legal systems of the continental Europeans, but very well known by the Anglo-Saxon systems. The stated goal is to encourage debate on these alternatives to resolve conflicts in society, with special attention to mediation.
Zvaigžņotā Debess: 2011, Rudens (213)
2011
Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: A.Spektors. New Radiotelescopes (abridged) ; N.Cimahoviča. Solar Researchers Gather in Samarkand (abridged) ; DEVELOPMENTS in SCIENCE: M.Krastiņš. Smallest Planet of Solar System: Riddle of Centuries (2nd part) ; NEWS: A.Alksnis. New Look at „Oddball” Star Cluster NGC 6791 ; CONFERENCE “The VIEW from SPACE. FIRST MANNED SPACE FLIGHT – 50”: U.Stirna. Creation of Space Technologies and Materials ; ACADEMIC STAFF of the UNIVERSITY of LATVIA: A.Salītis. Centenary of Latvian Astronomer Professor K.Šteins (1911-1983) ; LATVIAN SCIENTISTS: I.Vilks. Remembering Leonora Roze (1928-2010) ; For SCHOOL YOUTH: A.Bruņeniece, I.Dudareva. Human Adventure in Sp…
Kalanchoe pinnata inhibits mast cell activation and prevents allergic airway disease
2011
Aqueous extract of Kalanchoe pinnata (Kp) have been found effective in models to reduce acute anaphylactic reactions. In the present study, we investigate the effect of Kp and the flavonoid quercetin (QE) and quercitrin (QI) on mast cell activation in vitro and in a model of allergic airway disease in vivo. Treatment with Kp and QE in vitro inhibited degranulation and cytokine production of bone marrow-derived mast cells following IgE/FcɛRI crosslinking, whereas treatment with QI had no effect. Similarly, in vivo treatment with Kp and QE decreased development of airway hyperresponsiveness, airway inflammation, goblet cell metaplasia and production of IL-5, IL-13 and TNF. In contrast, treatm…
Potential Antipsoriatic Avarol Derivatives as Antioxidants and Inhibitors of PGE2 Generation and Proliferation in the HaCaT Cell Line
2004
The synthesis and structure-activity relationships for a series of 14 new avarol derivatives as antioxidants and inhibitors of cell proliferation and PGE(2) generation in human keratinocytes are described. Compound 6 (thiosalicylic derivative) was the most potent inhibitor of superoxide generation in human neutrophils and also potently inhibited PGE(2) generation in the human keratinocyte HaCaT cell line. Compound 7(3'-methylaminoavarone) presented the best antiproliferative profile, by the inhibition of (3)H-thymidine incorporation in HaCaT cells, with potency similar to the reference compound anthralin. None of the avarol derivatives showed any sign of cytotoxicity measured as LDH release…