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RESEARCH PRODUCT
Kalanchoe pinnata inhibits mast cell activation and prevents allergic airway disease
Helen MartinMichelle Frazão MuzitanoSônia Soares CostaChristian TaubeSebastian ReuterE.a. CruzRoland BuhlMichael StassenBartira Rossi-bergmannNina Dehzadsubject
KalanchoeOvalbuminmedicine.medical_treatmentBasophil Degranulation TestPharmaceutical ScienceInflammationImmunoglobulin EMiceIn vivoDrug DiscoverymedicineAnimalsMast CellsPharmacologyMetaplasiaMice Inbred BALB CGoblet cellInterleukin-13biologyPlant ExtractsTumor Necrosis Factor-alphabusiness.industryDegranulationIn vitroCytokinemedicine.anatomical_structureComplementary and alternative medicineImmunologybiology.proteinMolecular MedicineQuercetinTumor necrosis factor alphaGoblet CellsBronchial HyperreactivityInterleukin-5medicine.symptombusinessPhytotherapydescription
Aqueous extract of Kalanchoe pinnata (Kp) have been found effective in models to reduce acute anaphylactic reactions. In the present study, we investigate the effect of Kp and the flavonoid quercetin (QE) and quercitrin (QI) on mast cell activation in vitro and in a model of allergic airway disease in vivo. Treatment with Kp and QE in vitro inhibited degranulation and cytokine production of bone marrow-derived mast cells following IgE/FcɛRI crosslinking, whereas treatment with QI had no effect. Similarly, in vivo treatment with Kp and QE decreased development of airway hyperresponsiveness, airway inflammation, goblet cell metaplasia and production of IL-5, IL-13 and TNF. In contrast, treatment with QI had no effect on these parameters. These findings demonstrate that treatment with Kp or QE is effective in treatment of allergic airway disease, providing new insights to the immunomodulatory functions of this plant.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-02-05 | Phytomedicine |