Search results for "AMT"
showing 10 items of 90 documents
Late onset and pregnancy-induced congenital thrombotic thrombocytopenic purpura
2014
SummaryWe report on our patient (case 2) who experienced a first acute episode of thrombotic thrombocytopenic purpura (TTP) at the age of 19 years during her first pregnancy in 1976 which ended in a spontaneous abortion in the 30th gestational week. Treatment with red blood cell concentrates was implemented and splenectomy was performed. After having suffered from several TTP episodes in 1977, possibly mitigated by acetylsalicylic acid therapy, an interruption and sterilization were performed in 1980 in her second pregnancy thereby avoiding another disease flare-up. Her elder sister (case 1) had been diagnosed with TTP in 1974, also during her first pregnancy. She died in 1977 during her se…
Role of the Netrin-like Domain of Procollagen C-Proteinase Enhancer-1 in the Control of Metalloproteinase Activity
2010
The netrin-like (NTR) domain is a feature of several extracellular proteins, most notably the N-terminal domain of tissue inhibitors of metalloproteinases (TIMPs), where it functions as a strong inhibitor of matrix metalloproteinases and some other members of the metzincin superfamily. The presence of a C-terminal NTR domain in procollagen C-proteinase enhancers (PCPEs), proteins that stimulate the activity of astacin-like tolloid proteinases, raises the possibility that this might also have inhibitory activity. Here we show that both long and short forms of the PCPE-1 NTR domain, the latter beginning at the N-terminal cysteine known to be critical for TIMP activity, show no inhibition, at …
Old and New Drugs for Treatment of Advanced Heart Failure.
2020
Background: Advanced heart failure (HF) is a progressive disease with high mortality and limited medical therapeutic options. Long-term mechanical circulatory support and heart transplantation remain goldstandard treatments for these patients; however, access to these therapies is limited by the advanced age and multiple comorbidities of affected patients, as well as by the limited number of organs available. Methods: Traditional and new drugs available for the treatment of advanced HF have been researched. Results: To date, the cornerstone for the treatment of patients with advanced HF remains water restriction, intravenous loop diuretic therapy and inotropic support. However, many patien…
Bericht der Commission in Sachen der Organisation der neuen communalen Verwaltungsorgane: Organisationsplan
1878
"Auf Verfügen des Rigaschen Stadthaupts als Manuscript gedruckt."
Uenighetsdramaturgier
2019
Hvordan kan samtidsteater bli arena, laboratorium og katalysator for «uenighetsfellesskaper» (Iversen, 2014)? I denne artikkelen drøfter jeg teatersituasjonens potensial for uenighetsfellesskap og ser uenighet i forestillinger i relasjon til uenighet om forestillinger før jeg analyserer to eksempler på «uenighetsdramaturgier». I de kontekstsensible analysene undersøker jeg hvordan publikumets interne uenighet kommer til uttrykk, og hvordan det dramaturgisk legges til rette for denne uenigheten.
Teacher Educators’ Professional Identity in English-Medium Instruction at a Finnish University
2021
Publisher Copyright: © 2021, University of Ljubljana. All rights reserved. Although different forms of English-medium instruction (EMI) are being recognised, the different ways in which EMI can impact the pedagogical activities and expertise of higher education educators have received less attention. Using face-to-face and written interviews with nine teacher educators at a Finnish university, this study examines the most important aspects teacher educators perceive in their work through EMI and how these aspects connect to the understanding of their professional identity. The study is theoretically premised on the interconnected concepts of pedagogical doing, pedagogical being, pedagogical…
En kvalitativ studie om pårørendes erfaringer knyttet til etterlattesamtale med sykepleier fra en kommunal institusjon
2014
Masteroppgave i helsefag ME 518 Universitetet i Agder 2014 Background: There is a deficiency of bereavement support in Norwegian municipalities. The deficiency is shown in the existing literature of the relatives point of view, both national and internationally. The bereavement support is important forthe bereaved and the palliative care. The follow-up could have a positive effect onthe bereaved. The aim of the study was to gain knowledge about the family membersexperience with follow- up, conducted by a community nurse from a municipalinstitution.Method: The study used a qualitative, descriptive method. Qualitative interviews wereconducted with 7 relatives to earlier cancer patients from t…
Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura
2020
Recently, we showed that ADAMTS13 circulates in an open conformation during the acute phase of immune-mediated thrombotic thrombocytopenic purpura (iTTP). Although the cause of this conformational change remains elusive, ADAMTS13 is primarily closed in iTTP patients in remission with ADAMTS13 activity >50% and undetectable anti-ADAMTS13 autoantibodies, as well as after rituximab treatment, suggesting a role for anti-ADAMTS13 autoantibodies. Therefore, immunoglobulin G from 18 acute iTTP patients was purified and added to closed ADAMTS13 in healthy donor plasma. This resulted in open ADAMTS13 in 14 of 18 (78%) samples, proving that anti-ADAMTS13 autoantibodies can induce an open ADAMTS13 con…
The Carbon Monoxide-Releasing Molecule Tricarbonyldichlororuthenium(II) Dimer Protects Human Osteoarthritic Chondrocytes and Cartilage from the Catab…
2008
We have investigated the effects of a carbon monoxide-releasing molecule, tricarbonyldichlororuthenium(II) dimer (CORM-2), on catabolic processes in human osteoarthritis (OA) cartilage and chondrocytes activated with interleukin-1beta. In these cells, proinflammatory cytokines induce the synthesis of matrix metalloproteinases (MMPs) and aggrecanases, including members of a disintegrin and metalloproteinase with thrombospondin domain (ADAMTS) family, which may contribute to cartilage loss. CORM-2 down-regulated MMP-1, MMP-3, MMP-10, MMP-13, and ADAMTS-5 in OA chondrocytes, and it inhibited cartilage degradation. These effects were accompanied by increased aggrecan synthesis and collagen II e…
Drug-induced variations of the renin-angiotensin-aldosterone system in rats. I. Diuretics.
1977
Summary Groups of 10 rats were treated with diuretics (furosemide, hydrochlorotiazide, spironolactone, triamterene) under conditions of high or low plasma renin activity (PRA) brought about by administering distilled water or saline load, respectively. PRA, plasma aldosterone levels, urine aldosterone concentration as well as diuresis and Na+ and K+ excretion were