Search results for "ANSM"
showing 10 items of 3078 documents
Una aproximación a la perspectiva de género en drogodependencias y VIH/SIDA
2002
En el presente trabajo se aborda la necesidad de integrar el concepto de genero como un factor a considerar en la problemática de las drogodependencias y VIH/Sida. El contenido de este concepto esta basado en el carácter relacional Hombre/mujer Se aportan datos acerca de la situación epidemiológica, así como factores relevantes y problemas específicos a partir de estudios realizados en todo el mundo, pero haciendo especial énfasis en las zonas no desarrolladas, donde el impacto de la pobreza es un fuerte potenciador del VlH/Sida y drogas. Se reseñan algunos esfuerzos por abordar la perspectiva de género como el programa de Igualdad de Oportunidades entre hombres y mujeres de la Unión Europe…
La importancia de la detección precoz
2002
Descripción de la evolución del número de pruebas efectuadas durante el periodo 1992-2001 en las consultas anónimas de detección del VIH en el Pais Vasco así como las prácticas de riesgo que aconsejan la prueba.Los resultados indican claramente el aumento de las serologías positivas por relaciones sexuales de riesgo confirmando la tendencia mundial de la epidemia.Además, los resultados obtenidos del análisis retrospectivo de todos los casos de nueva infección por-VIH detectados en el conjunto del País vasco en los 5 últimos años indican una alta coincidencia del diagnóstico VlH con el de Sida.Por este motivo en junio de 2002 se ha realizado una campaña de prevención para sensibilizar a la p…
Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the a…
2015
Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We evaluated the protective effects of the selective CB1 receptor agonist ACEA, the selective CB2 receptor agonist JWH133 and the fatty-acid amide-hydrolase (FAAH) inhibitor URB597, which enhances endocannabinoid receptor activity, on NPC proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. We performed immunohistochemical and stereological analyses of cells expressing the mitotic phosphorylation of his…
Adenosine negatively regulates duodenal motility in mice: role of A1 and A2a receptors .
2011
Trichuris trichiura egg extract proteome reveals potential diagnostic targets and immunomodulators.
2021
The proteomic analysis was performed at the proteomics facility of SCSIE, University of Valencia (Burjassot, Spain) that belongs to ProteoRed, PRB2-ISCIII, Madrid, Spain. We also thank Dr. Tatiana Corey, Dr. Amy Beierschmitt and Dr. Pompei Bolfa for their support during sample collection.
The IceCube data acquisition system: Signal capture, digitization, and timestamping
2008
IceCube is a km-scale neutrino observatory under construction at the South Pole with sensors both in the deep ice (InIce) and on the surface (IceTop). The sensors, called Digital Optical Modules (DOMs), detect, digitize and timestamp the signals from optical Cherenkov-radiation photons. The DOM Main Board (MB) data acquisition subsystem is connected to the central DAQ in the IceCube Laboratory (ICL) by a single twisted copper wire-pair and transmits packetized data on demand. Time calibration is maintained throughout the array by regular transmission to the DOMs of precisely timed analog signals, synchronized to a central GPS-disciplined clock. The design goals and consequent features, func…
Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
2021
Graphical abstract
Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon
2007
BACKGROUND AND PURPOSE: This study analysed the contribution of the purinergic system to enteric neurotransmission in the longitudinal muscle of mouse distal colon. EXPERIMENTAL APPROACH: Motor responses to exogenous ATP and to nerve stimulation in vitro were assessed as changes in isometric tension. KEY RESULTS: ATP induced a concentration-dependent contraction, reduced by 4-[[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzene disulphonic acid (PPADS), suramin, P2Y purinoreceptor desensitisation with adenosine 5'-O-2-thiodiphosphate (ADPbetaS), and atropine, but unaffected by P2X purinoceptor desensitisation with alpha,beta-methylene ATP (alpha,beta-meATP) an…
The Arabidopsis heavy metal P-type ATPase HMA5 interacts with metallochaperones and functions in copper detoxification of roots
2005
*† ‡ § Summary Since copper (Cu) is essential in key physiological oxidation reactions, organisms have developed strategies for handling Cu while avoiding its potentially toxic effects. Among the tools that have evolved to cope with Cu is a network of Cu homeostasis factors such as Cu-transporting P-type ATPases that play a key role in transmembrane Cu transport. In this work we present the functional characterization of an Arabidopsis Cutransporting P-type ATPase, denoted heavy metal ATPase 5 (HMA5), and its interaction with Arabidopsis metallochaperones. HMA5 is primarily expressed in roots, and is strongly and specifically induced by Cu in whole plants. We have identified and characteriz…
Development and Characterization of an Amorphous Solid Dispersion of Furosemide in the Form of a Sublingual Bioadhesive Film to Enhance Bioavailabili…
2017
Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoadhesive sublingual fast-dissolving FUR based film has been developed and evaluated in order to optimize the bioavailability of FUR by increasing solubility and guaranteeing a good dissolution reproducibility. The Differential Scanning Calorimetry (DSC) analyses confirmed that the film prepared using the solvent casting method entrapped FUR in the amorphous state. As a solid dispersion, FUR increa…