Search results for "APR"
showing 10 items of 2648 documents
La Neurodidáctica como transdisciplina
2017
El capítulo tiene como finalidad presentar la Neurodidáctica como transdisciplina, encontrándose y trabajando ella misma en la encrucijada entre las Neurociencias y la Didáctica, para promover un desarrollo equilibrado de todo proceso de aprendizaje.
A NEW SOLVER FOR NON-ISOTHERMAL FLOWS IN NATURAL AND MIXED CONVECTION
2022
Most thermal fluid flow of real-life practical problems fall in the category of low Mach-number or incompressible flow (e.g., industrial flows inside ducts, or around stationary/moving objects, flows in biological/biomedical problems, or atmospheric flows). Several numerical techniques have been proposed for simulation of thermal flows, Finite Difference (FDM), Finite Element (FEM), Finite Volume (FVM) and Lattice Boltzmann (LBM) methods. Unlike the FVMs and FEMs, the classical FDMs show some difficulties in handling irregular geometries. Conventional formulation of FEMs (e.g., Galerkin FEMs) suffers from the lack of local mass balance, recovered by modified formulations (Narasimhan & W…
Sapratīga termiņa jēdziens un noteikšana Patērētāju tiesības aizsardzības likuma 28.panta ceturtās daļas kontektā
2022
Šī darba mērķis ir izpētīt Patērētāju tiesību aizsardzības likuma 28.panta ceturtajā daļā paredzētās pārdevēja vai pakalpojuma sniedzēja tiesības un pienākumus pret patērētāju, kad pirkuma objekts, kuram ir trūkumi, apmaināms vai tā neatbilstība līguma noteikumiem novēršama saprātīgā termiņā, noskaidrot šī panta atbilstību Eiropas Savienības Direktīvām, kā arī analizēt, saprast un salīdzināt juridiskās literatūras autoru domas attiecībā uz šo pantu. Tāpat darbā tiks apstiprināti vai apgāzti pieņēmumi, interpretēti viedokļi un iegūti jauni viedokļi par iespējamiem risinājumiem un uzskatiem, kādam vajadzētu būt saprātīgam termiņam, lai labāk saprastu kā rīkoties gan patērētājam, gan pārdevēja…
Lipid nanocarriers containing sorafenib inhibit colonies formation in human hepatocarcinoma cells
2015
Here, the potential of two nanostructured lipid carriers (NLC) for controlled release of sorafenib was evaluated. The obtained systems showed characteristics suitable as drug delivery systems for the treatment of hepatocellular carcinoma (HCC) through parenteral administration. The use of a mixture between a solid lipid (tripalmitin) with a liquid lipid (Captex 355 EP/NF or Miglyol 812) to prepare NLC systems could give a higher drug loading capacity and a longer term stability during storage than that obtained by using only solid lipids. The obtained nanoparticles showed a nanometer size and high negative zeta potential values. Scansion electron microscopy (SEM) of the sorafenib loaded NLC…
Pharmacological and biochemical study on the effects of selective phosphodiesterase inhibitors on human term myometrium
1999
This study was aimed at evaluating the in vitro effects of phosphodiesterase inhibitors and beta2-adrenoceptor agonists on spontaneous contractions of human term myometrium. Rolipram, RP 73401 (3-cyclopentyloxy-N-(3,5(-dichloro-4-pyridil)-4-methoxybenzamide) and Ro 20-1724 (1-4-(3-butoxy-4-methoxybenzyl)-2-imidozolidinone) (phosphodiesterase 4 inhibitors) inhibited spontaneous myometrial contractions (Emax approximately 100%; pD2 of 6.80+/-0.28, 6.84+/-0.32 and 6.31+/-0.03, respectively). Salbutamol and formoterol were less effective (Emax=40+/-6% and 35+/-12%, respectively) than phosphodiesterase 4 inhibitors to reduce myometrial contractility. Inhibitors of phosphodiesterase 3 (milrinone …
Interplay between Intestinal Bacterial Communities and Unicellular Parasites in a Morbidly Obese Population: A Neglected Trinomial
2022
Obesity is an epidemic causing a metabolic health crisis. Herein, the interactions between the gut prokaryotic and eukaryotic communities, metabolic comorbidities and diet were studied. Stool samples from 56 subjects, 47 with type III obesity and 9 with type II obesity and cardiovascular risk or metabolic disease, were assessed for the richness, diversity and ecology of the bacterial gut community through metagenomics, together with the study of the presence of common unicellular eukaryote parasites (Blastocystis sp., Dientamoeba fragilis and Giardia intestinalis) by qPCR. Clinical information regarding metabolic comorbidities and non-alcoholic hepatic fatty liver disease was gathered. To a…
Terminology and classification of miracle slimming diets: A narrative review and new proposals
2021
Introduction: In the last years, confusing or misleading use of the term called miracle or magic diets, using to weight loss treatment, has increased, along with several classification of them. Objectives: The purpose of this narrative review is to discuss miracle slimming diets and proposal new term and new classification for these diets. Methods: A narrative review up to September 2021 was carried out in the PubMed, Google Scholar, and Web of Knowledge. Furthermore, this strategy was complemented with a comprehensive search of the 'grey' literature [7] based in four different searching strategies: i) grey literature databases, ii) customized Google search engines, iii) targeted websites, …
Ceļš uz obligāto veselības apdrošināšanas ieviešanu Latvijā
2016
Bakalaura darba tēma - „Ceļš uz obligātās veselības apdrošināšanas ieviešanu Latvijā” tika izvēlēta, jo veselības aprūpes nozare Latvijā ir nesakārtota un tai ir nepieciešamas pārmaiņas, kā iespējamā variantā ieviešot obligāto veselības apdrošināšanu. Darbā tiek raksturots šobrīd valstī pastāvošais veselības aprūpes finansējums, analizēta obligātā veselības apdrošināšana kā tāda, pētīta obligātā veselības apdrošināšana citās valstīs un meklētas problēmas, kas liedz obligāto veselības apdrošināšanu ieviest Latvijā. Darba mērķis ir balstoties uz pieejamo literatūru, publikācijām un normatīvajiem aktiem, identificēt nozīmīgākās problēmas, kas traucē ieviest obligāto veselības apdrošināšanu Lat…
Synthesis and Oxidant Properties of Phase 1 Benzepine N-Oxides of Common Antipsychotic Drugs
2013
There is increasing evidence that cell constituents are oxidized by widely used antipsychotic drugs but until now the underlying chemistry has remained unclear. It is well known that such drugs readily undergo N-oxidation as a first key metabolic step. To gain insight into the problem, the tertiary phase 1 N-oxides of clozapine, olanzapine, quetiapine, and zotepine were synthesized, together with the N,S-dioxides of quetiapine and zotepine. These N-oxides were then subjected to well-established chemical transformations to test their oxidant properties in group VIII transition-metal-catalyzed reactions. In the osmium tetroxide catalyzed dihydroxylation of styrene or cinnamyl alcohol and in …
Non-hindered ansasamarocenes, versatile catalysts for diene/olefin/polar monomer copolymerisations. What is really the active species?
2002
Abstract Catalytic systems containing an ansabiscyclopentadienyllanthanide core and lithium and/or magnesium salts are obtained by reaction of the chloride precursors with allyllithium. These allyl complexes lead to the same active species which polymerises 1,3-dienes, copolymerises 1,3-dienes and α-olefin or α,ω-dienes or allows the controlled diblock polyisoprene/polycaprolactone copolymerisation. The exact nature of this active species and of the allyl precursors is investigated here.