Search results for "ARTICLES"
showing 10 items of 9626 documents
Model for T2K indication with maximalθ23and trimaximalθ12
2011
Recently T2K experiment gives hint in favor of large reactor angle ${\ensuremath{\theta}}_{13}$. Most of the models, with tribimaximal mixing at the leading order, can not reproduce such a large mixing angle since they predict typically corrections for the reactor angle of the order ${\ensuremath{\theta}}_{13}\ensuremath{\sim}{\ensuremath{\lambda}}_{C}^{2}$, where ${\ensuremath{\lambda}}_{C}\ensuremath{\sim}0.2$. In this paper, we discuss the possibility to achieve large ${\ensuremath{\theta}}_{13}$ within the T2K region with maximal atmospheric mixing angle, ${sin}^{2}{\ensuremath{\theta}}_{23}=1/2$, and trimaximal solar mixing angle, ${sin}^{2}{\ensuremath{\theta}}_{12}=1/3$, through th…
Advanced Virgo Status
2015
Abstract The detection of a gravitational wave signal in September 2015 by LIGO interferometers, announced jointly by LIGO collaboration and Virgo collaboration in February 2016, opened a new era in Astrophysics and brought to the whole community a new way to look at - or “listen” to - the Universe. In this regard, the next big step was the joint observation with at least three detectors at the same time. This configuration provides a twofold benefit: it increases the signal-to-noise ratio of the events by means of triple coincidence and allows a narrower pinpointing of GW sources, and, in turn, the search for Electromagnetic counterparts to GW signals. Advanced Virgo (AdV) is the second ge…
Signals of major histocompatibility complex overdominance in a wild salmonid population
2009
The major histocompatibility complex (MHC) contains the most variable genes in vertebrates, but despite extensive research, the mechanisms maintaining this polymorphism are still unresolved. One hypothesis is that MHC polymorphism is a result of balancing selection operating by overdominance, but convincing evidence for overdominant selection in natural populations has been lacking. We present strong evidence consistent with MHC-specific overdominance in a free-living population of Arctic charr (Salvelinus alpinus) in northernmost Europe. In this population, where just two MHC alleles were observed, MHC heterozygous fish had a lower parasite load, were in better condition (as estimated by a…
Recent advances on aptamer-based biosensors to detection of platelet-derived growth factor.
2018
Platelet-derived growth factor (PDGF-BB), a significant serum cytokine, is an important protein biomarker in diagnosis and recognition of cancer, which straightly rolled in proceeding of various cell transformations, including tumor growth and its development. Fibrosis, atherosclerosis are certain appalling diseases, which PDGF-BB is near to them. Generally, the expression amount of PDGF-BB increases in human life-threatening tumors serving as an indicator for tumor angiogenesis. Thus, identification and quantification of PDGF-BB in biomedical fields are particularly important. Affinity chromatography, immunohistochemical methods and enzyme-linked immunosorbent assay (ELISA), conventional m…
Not just for tumor targeting: unmet medical needs and opportunities for nanomedicine.
2015
During the last 3 decades, nanomedicines have provided novel opportunities to improve the delivery of chemotherapeutics in cancer therapy effectively. However, many principles learnt from there have the potential to be transferred to other diseases. This perspective article, on the one hand, critically reflects the limitations of nanomedicines in tumor therapy and, on the other hand, provides alternative examples of nanomedicinal applications in immunotherapy, noninvasive drug deliveries across epithelial barriers and strategies to combat intra- and extra-cellular bacterial infections. Looking ahead, access to highly complex nanoparticular delivery vehicles given nowadays may allow further…
Magnetic nanoparticles between electrodes of tunnel junction: anomalous tunnel conductance
2002
Abstract Magnetic particles of microscopic size can be created in the process of Ni, Fe and Co mechanically controllable break junctions fabrication and trapped between the electrodes by magnetic dipole forces. Tunneling between the protruding nanoparticle and the sample electrode shows clear distinctions from the usual junctions: heavy deviation of the current–distance I(z) dependence from the expected exponential behavior at electrode separations z below 4.0– 4.5 A and on numerous occasions a sudden jump-like decrease of the tunnel current at z≈1.5– 2.0 A . Possible mechanisms behind observed anomalies including the short-range magnetic exchange coupling are discussed.
Comparative toxicity and cell-tissue distribution study on nanoparticular iron complexes using avian embryos and HepG2-cells
2007
In this study the toxicity and intracellular availability of iron from iron dextran (FeD), iron sucrose (FeS), and iron gluconate (FeG) was compared in organs of avian (turkey) embryos and in isolated cells (HepG2) in cell culture. Iron uptake was more pronounced in embryonic liver than in renal tissue. Cellular iron uptake in liver and kidney was more or less similar for the different compounds. Only some experiments showed slightly greater iron concentrations in liver and kidney with FeG compared with FeD and FeS. Significant differences were found in the survival ratios of the eggs and the embryo weights depending on the type of iron complex administered. The rank order of toxicities was…
Evaluation of an Algorithm for Retrospective Hypoglycemia Detection Using Professional Continuous Glucose Monitoring Data.
2014
Background: People with type 1 diabetes (T1D) are unable to produce insulin and thus rely on exogenous supply to lower their blood glucose. Studies have shown that intensive insulin therapy reduces the risk of late-diabetic complications by lowering average blood glucose. However, the therapy leads to increased incidence of hypoglycemia. Although inaccurate, professional continuous glucose monitoring (PCGM) can be used to identify hypoglycemic events, which can be useful for adjusting glucose-regulating factors. New pattern classification approaches based on identifying hypoglycemic events through retrospective analysis of PCGM data have shown promising results. The aim of this study was to…
Thermo-oxidative resistant UHMWPE-based nanocomposites containing hybrid-nanoparticles based on natural anti-oxidants and carbon nanotubes
2015
The use of natural antioxidants is an attractive way to formulate nanocomposites with extended durability and with potential applications in bio-medical field. In this work, Vitamin E (VE) in the form of α-tocopherol and Quercetin (Q) were physically immobilized onto multi-walled carbon nanotubes bearing covalently-linked long-chain alkyl ester groups (CNTs) and the resulting hybrids CNTs-VE and CNTs-Q were used to formulate thermo-oxidation stable ultra high molecular weight polyethylene based nanocomposites. The thermo-oxidation of the nanocomposites was performed at 120°C in air oven. The samples were then subjected to FTIR analyses at different annealing times. The accurate analysis of …
Coupling colloidal chemistry with coordination chemistry: Design of hybrid nanomaterials by the assembly of plasmonic nanoparticles and functional co…
2021
Nanotechnology involves the design, characterization, production and application of structures, devices and systems by the control of the shape and size at the nanometer scale involving different fields. In the last decade, nanotechnology development has boosted the interest in hybrid nanomaterials. These materials are a complimenting combination of two (or more) nanoparticles (NPs) with enhanced performance characteristics that offer exciting opportunities. It allows the possibility of integrating materials with different physical and chemical properties to widen the range of practical applications. In this context, Au NPs have recently attracted a lot of attention due to the great opportu…