Search results for "ARX"

Novel Antihypertensive Lactoferrin-Derived Peptides Produced by Kluyveromyces marxianus: Gastrointestinal Stability Profile and In Vivo Angiotensin I…

2014

Novel antihypertensive peptides released by Kluyveromyces marxianus from bovine lactoferrin (LF) have been identified. K. marxianus LF permeate was fractionated by semipreparative high performance liquid chromatography and 35 peptides contained in the angiotensin I-converting enzyme (ACE)-inhibitory fractions were identified by using an ion trap mass spectrometer. On the basis of peptide abundance and common structural features, six peptides were chemically synthesized. Four of them (DPYKLRP, PYKLRP, YKLRP, and GILRP) exerted in vitro inhibitory effects on ACE activity and effectively decreased systolic blood pressure after oral administration to spontaneously hypertensive rats (SHRs). Stab…

Correlation between type 2 diabetes, dry eye and Meibomian glands dysfunction

2019

espanolObjetivo Evaluar las glandulas de Meibomio, la superficie ocular y la funcion de la lagrima en pacientes con diabetes tipo 2, y estudiar la correlacion entre estas situaciones. Metodos Estudio prospectivo de 76 varones, 37 de ellos con diabetes tipo 2, con una media de duracion de entre 7±5 anos, y 36 mujeres como grupo control. Tras completar el cuestionario del indice de enfermedad de la superficie ocular (OSDI), se obtuvieron el tiempo de ruptura lagrimal no invasivo (NIBUT) y el patron de la capa lipidica de la lagrima utilizando interferometria y altura del menisco lagrimal/AML. Se estudio la superficie ocular con tincion verde de lisamina y la morfologia de las glandulas con ev…

Further Delineation of Duplications of ARX Locus Detected in Male Patients with Varying Degrees of Intellectual Disability

2022

The X-linked gene encoding aristaless-related homeobox (ARX) is a bi-functional transcription factor capable of activating or repressing gene transcription, whose mutations have been found in a wide spectrum of neurodevelopmental disorders (NDDs); these include cortical malformations, paediatric epilepsy, intellectual disability (ID) and autism. In addition to point mutations, duplications of the ARX locus have been detected in male patients with ID. These rearrangements include telencephalon ultraconserved enhancers, whose structural alterations can interfere with the control of ARX expression in the developing brain. Here, we review the structural features of 15 gain copy-number variants …

Exploratory study of the hoaxes spread via WhatsApp in Spain to prevent and/or cure COVID-19

2021

Objective: To review the hoaxes’ characteristics spread through WhatsApp in Spain during COVID-19 lockdown and identify what kind of substances were promoted for consumption or application. Method: A phone number was activated to receive hoaxes via WhatsApp. A total of 2353 messages were collected, and among those 584 different hoaxes were identified and validated, between March 18 and April 18, 2020. From these 584 hoaxes, a sub-sample of 126 was selected, exclusively related to the object of study, and a content analysis table with fourteen registration fields was applied. Besides, the averages and medians of the quantitative fields were extracted. Results: Most of the messages received w…

Emprendimiento en personas con discapacidad. Un diagnóstico a través de la técnica de grupo nominal

2018

The aim of this work is to identify the dimensions and aspects that foster and / or restrict the entrepreneurial action of disabled people from a qualitative methodological perspective. The analysis was carried out by means of the nominal group technique. As a result of the analysis, this work proposes, through the work done with disabled people, a set of interventions that will reduce barriers and foster the entrepreneurship of such vulnerable group

Canon vs. charisma : "Maoism" as an ideological construction

2006

Mao Zedongin (1893–1976) poliittinen ja ideologinen perintö on tutkimuksellisesti jälleen ajankohtainen, kolmekymmentä vuotta ”suuren ruorimiehen” kuoleman jälkeen. Maoa on kuvattu milloin puhdasoppiseksi marxilaiseksi, milloin kiinalaiseksi patriootiksi. Maoismin tutkimuksessa on usein keskusteltu siitä, missä määrin Mao seurasi perinteisiä marxilaisia oppeja ja missä määrin hän taas sisällytti kiinalaisia elementtejä omaan ideologiseen tulkintaansa. Viime aikoina julkisuuteen tulleet historiantulkinnat sen sijaan pyrkivät osoittamaan, että Mao oli vain tunteeton ja väkivaltaan taipuvainen itsevaltias.Kauppinen esittää väitöstyössään, että Maon ideologisen maailmankatsomuksen kannalta ei o…

Profilo critico-bibliografico di Marcello Cappuzzo

2011

Desafíos del sindicalismo italiano ante el trabajo sindical con trabajadores ?contingentes? en Amazon

2021

Право на лѣность: опроверженіе "Права на трудъ", 1848 г. [ Право на леность...]

1905

Содержание: Предисловие ; Право на леность : (опровержение "Права на труд", 1848 г.), I. ; II. Благословение труда ; III. То, что следует за перепроизводством ; IV. Новыя птицы - новыя песни ; Приложение.

Nota introduttiva. Dagli "idoli di legna dei renani" all'afrofuturismo

2021

Una introduzione alla sezione "Cultural Studies" del volume