Search results for "ASC"

"La dernière lettre de G. A. Borgese à Mussolini"

2008

Association between clusters of diseases and polypharmacy in hospitalized elderly patients: results from the REPOSI study.

2011

BACKGROUND: Although the association between multimorbidity and polypharmacy has been clearly documented, no study has analyzed whether or not specific combinations of diseases influence the prescription of polypharmacy in older persons. We assessed which clusters of diseases are associated with polypharmacy in acute-care elderly in-patients. METHODS: This cross-sectional study was held in 38 Italian internal medicine and geriatric wards participating in the Registro Politerapie SIMI (REPOSI) study during 2008. The study sample included 1155 in-patients aged 65 years or older. Clusters of diseases, defined as two or more co-occurring specific chronic diseases, were identified using the odds…

SiC MOSFET vs SiC/Si Cascode short circuit robustness benchmark

2019

Abstract Nowadays, MOSFET SiC semiconductors short circuit capability is a key issue. SiC/Si Cascodes are compound semiconductors that, in some aspects, show a similar MOSFET behaviour. No interlayer dielectric insulation suggests, in theory, Cascode JFETs as more robust devices. The purpose of this paper is to compare the drift and degradation of two commercial devices static parameters by exposing them to different levels of repetitive 1.5 μs short-circuit campaigns at 85% of its breakdown voltage. Short-circuit time has been set experimentally, and longer times result in catastrophic failure of MOSFET devices due to over self-heating. For this purpose, pre- and post-test short circuit ch…

The Acoustic Wave Behavior Within the PEA Cell for Space Charge Measurement

2018

In order to evaluate the acoustic wave behavior within the Pulsed Electro Acoustic (PEA) cell, a simulation model has been developed in this work. The model, implemented in Matlab environment, is based on the analogy between acoustic and electrical quantities. Therefore, it was possible to model the PEA cell as cascade connected lossy transmission lines. The model has been validated theoretically by making a comparison with a simulation result found in literature. The experimental validation has also been made by using the PEA cell of the LEPRE high voltage lab. In addition, four graphs have been realized. Two of them can be used to establish in easy and fast way to obtain the minimum groun…

Infrared Spectroscopy of Disilicon-Carbide, Si2C: The ν3 Fundamental Band

2019

The ν3 antisymmetric stretching mode of disilicon-carbide, Si2C, was studied using a narrow line width infrared quantum cascade laser spectrometer operating at 8.3 μm. The Si2C molecules were produ...

Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes

2018

We report a novel metal–organic framework (MOF) featuring functional pores decorated with hydroxyl groups derived from the natural amino acid L-serine, which is able to establish specific interactions of different natures, strengths and directionalities with organic molecules of technological interest, i.e. ascorbic acid, pyridoxine, bupropion and 17-β-estradiol, based on their different sizes and chemical natures. The ability of 1 to distinctly organize guest molecules within its channels, through the concomitant effect of different directing supramolecular host–guest interactions, enables gaining unique insights, by means of single-crystal X-ray crystallography, into the host–guest intera…

Thiourea-Catalyzed Domino Michael–Mannich [3+2] Cycloadditions: A Strategy for the Asymmetric Synthesis of 3,3′-Pyrrolidinyl-dispirooxindoles

2017

The asymmetric synthesis of trifluoromethylated 3,3′-pyrrolidinyl-dispirooxindole derivatives with four contiguous stereogenic centers, including two vicinal spiro-stereocenters, is described. Employing a bifunctional thiourea catalyst, a domino Michael–Mannich [3+2] cycloaddition occurs readily between isatin ketimines and isatin-derived enoates with good yields and very high stereoselectivities, providing a direct entry to the title compounds of potential medical value.

Diabetes and renin-angiotensin-aldosterone system: Implications for covid-19 patients with diabetes treatment management

2020

In the context of the COVID-19 continuous spreading, this paper focuses on the increased risk of diabetic patients regarding the metabolic control and the uncertainties related to SARS-CoV-2 infection. Chronic hyperglycaemia negatively affects the immune system, which triggers an increase of morbidity and mortality for viral infections. A key aspect of COVID-19 resides in the involvement of renin-angiotensin-aldosterone (RAAS) system that causes a cascade of reactions mediated by vasoactive peptides with implications in vasoconstriction, vascular permeability, oxidative stress remodelling and tissue injuries. Activation of RAAS at pulmonary level, is responsible for the local damage. Many q…

Using scintillometry to assess reference evapotranspiration methods and their impact on the water balance of olive groves

2016

Abstract Reference evapotranspiration (ET 0 ) is widely used for irrigation scheduling, to promote an efficient use of water resources for a sustainable agro-ecosystem productivity, as well as to manage water quality and to face other environmental concerns. As suggested by ASCE-EWRI and FAO, standard Penman–Monteith methods are generally applied for an accurate estimation of ET 0 from hourly to daily scale. In absence of detailed meteorological information several simplified equations, using a limited number of variables, have been proposed as alternative. In this paper, the performance of different reference evapotranspiration methods, at hourly (Penman–Monteith, Pristley–Taylor, Makkink …

Cosmic-Ray Anisotropies in Right Ascension Measured by the Pierre Auger Observatory

2020

We present measurements of the large-scale cosmic-ray anisotropies in right ascension, using data collected by the surface detector array of the Pierre Auger Observatory over more than 14 years. We determine the equatorial dipole component, ~d⊥, through a Fourier analysis in right ascension that includes weights for each event so as to account for the main detector-induced systematic effects. For the energies at which the trigger efficiency of the array is small, the “East-West” method is employed. Besides using the data from the array with detectors separated by 1500 m, we also include data from the smaller but denser sub-array of detectors with 750 m separation, which allows us to extend …