Search results for "ASES"

Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene)alkanoic acids and rela…

2016

A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for a carboxy, cyano or amide group, or introducing substituents in the phenyl ring of the ester and acid derivatives. The most active derivative found was 3-oxo-2-(2-(3,4dichlorophenyl)hydrazinylidene)butanoic acid (2b), showing an IC50 value of 50 µM. For a preliminary assessment of their antivirulence properties the new derivatives were tested for their antibiofilm activity. The most active compo…

Gaming for health across various areas of life

2019

Lack of physical activity is mostly addressed by implementing programs to promote physical activity but seeing as the major cause for physical inactivity is that of technology. Few studies used the approach to use the very barrier as s mean to try and educate and breed good habits. This paper outlines the design and development of a project that will us various environments, home, gym and outdoors to promote physical activity by means of technology and more specifically games. peerReviewed

Prevalence of aphthous stomatitis in patients with inflammatory bowel disease after the treatment with monoclonal antibodies: a systematic review and…

2022

Currently, the most frequently employed therapies in the treatment of inflammatory bowel diseases (IBD), i.e., Crohn's Disease (CD), Ulcerative Colitis (UC) or unclassified IBD (IBD-U) are monoclonal anti-TNFs and anti-integrin therapies, such as vedolizumab (VDZ). Forty-seven per cent of these patients present extra-intestinal manifestations, the second most prevalent being aphthous stomatitis (AS). The present study aims to investigate which of the two therapies is associated with a lower prevalence of AS after treatment. An electronic search of the MEDLINE (via PubMed), Web of Science, SCOPUS, LILACS and OpenGrey databases was carried out. The criteria used were those described by the PR…

The effect of blue-light-blocking lenses on retinal straylight

2021

Sometimes yellow-tinted lenses are recommended to help improve visual quality. As yellow lenses filter blue light, it is believed that their use could decrease the intensity of scattered light in the eye (retinal straylight). However, the results of some studies have contradicted this assumption (Van Os et al. 2017). Currently various nontinted blue-light-blocking lenses are used to protect the eyes from short-wavelength light. The objective of this study was to determine whether blue-light-blocking lenses affect the levels of retinal straylight in the eye. A straylight meter (C-Quant, Oculus) was used for retinal straylight measurements. The measurements were performed under four different…

Recurrent lumbar disc herniation: Is there a correlation with the surgical technique? A multivariate analysis

2019

Purpose: The recurrence of a lumbar disc herniation (LDH) is a common cause of poor outcome following lumbar discectomy. The aim of this study was to assess a potential relationship between the incidence of recurrent LDH and the surgical technique used. Furthermore, we tried to define the best surgical technique for the treatment of recurrent LDH to limit subsequent recurrences. Materials and Methods: A retrospective study was conducted on 979 consecutive patients treated for LDH. A multivariate analysis tried to identify a possible correlation between (1) the surgical technique used to treat the primary LDH and its recurrence; (2) technique used to treat the recurrence of LDH and the secon…

Three-dimensional skyrmions in spin-2 Bose–Einstein condensates

2017

We introduce topologically stable three-dimensional skyrmions in the cyclic and biaxial nematic phases of a spin-2 Bose-Einstein condensate. These skyrmions exhibit exceptionally high mapping degrees resulting from the versatile symmetries of the corresponding order parameters. We show how these structures can be created in existing experimental setups and study their temporal evolution and lifetime by numerically solving the three-dimensional Gross-Pitaevskii equations for realistic parameter values. Although the biaxial nematic and cyclic phases are observed to be unstable against transition towards the ferromagnetic phase, their lifetimes are long enough for the skyrmions to be imprinted…

Update on standardization and interpretation of lung function test in adult and pediatric patients

2010

Latviešu tautas dejas kompozīcijas ietekme uz 7.klases skolēnu radošumu sporta stundās

2017

Diplomdarba tēma ir “Latviešu tautas dejas kompozīcijas ietekme uz 7. klases skolēnu radošumu sporta stundās”. Diplomdarba mērķis ir izstrādāt mācību darba modeļus sporta stundas tēmai “Latviešu tautas dejas kompozīcija” un atklāt sakarības starp pedagoģisko darbību un patstāvīgas deju kompozīcijas veidošanas ietekmi uz skolēnu radošumu sporta stundā. Darba teorētiskajā daļā tiek pētīta zinātniskā literatūra par kreativitātes jēdzienu un tās nozīmi mūsdienās, par latviešu tautas dejas vēsturi, kompozīciju un pamatelementiem kā arī par sporta stundas teorētiskajiem pamatiem. Darba pedagoģiskajā pētījuma daļā tiek izstrādāti radošo sporta stundu modeļi par tēmu “Latviešu tautas dejas kompozīc…

Qualitative mucin disorders in patients with primary Sjögren's syndrome:a literature review

2020

Background It is a common opinion that Primary Sjögren Syndrome (pSS) damages the exocrine glands and determines the reduction of secreted saliva, some studies show that there are qualitative anomalies of the mucins produced in saliva, including MUC7, MUC5B, MUC1. The purpose of this study is to trace all the information useful to establish whether there is a qualitative or quantitative defect of the mucins in the pSS. Material and Methods We reviewed the literature by looking for publications relevant to the topic in electronic databases. Sixteen articles met the search criteria. The studies were divided into two categories, those that studied the rheological characteristics of the saliva …

Commonalities between ENT Specialists and Oral Medicine Experts: Old HPV Diseases and New Oral HPV-Cancer along the Borders

2021

A human papillomavirus (HPV) infection is globally one of the most common causes of sexually transmitted infections of the mucous membranes (genital, anal and oral). Over the last decade, an increasing number of young patients have been infected due to the changes in sexual habits in the general population. The majority of the lesions are benign; however, substantial scientific evidence has suggested a role for the HPV family in the carcinogenesis of squamous cell carcinoma (SCC). It is proposed that dentists, in addition to ENT specialists, should apply standardized management protocols in order to construct a well-defined pathway in terms of diagnosis, which is based on a PCR diagnostic t…