Search results for "ASIS"
showing 10 items of 4190 documents
Extracellular vesicles in airway homeostasis and pathophysiology
2021
The epithelial–mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of the homeostasis of airways as well as in the pathogenesis of several diseases, including asthma and chronic obstructive pulmonary disease (COPD). The “muco-microbiotic layer” (MML) is the innermost layer of airways made by microbiota elements (bacteria, viruses, archaea and fungi) and the surrounding mucous matrix. The MML homeostasis is also crucial for maintaining the healthy status of organs and its alteration is at the basis of airway disorders. Nanovesicles produced by EMTU and MML elements are probably the most important tool of communication among the different cell types, inclu…
Molecular profile study of extracellular vesicles for the identification of useful small “hit” in cancer diagnosis
2021
Tumor-secreted extracellular vesicles (EVs) are the main mediators of cell-cell communication, permitting cells to exchange proteins, lipids, and metabolites in varying physiological and pathological conditions. They contain signature tumor-derived molecules that reflect the intracellular status of their cell of origin. Recent studies have shown that tumor cell-derived EVs can aid in cancer metastasis through the modulation of the tumor microenvironment, suppression of the immune system, pre-metastatic niche formation, and subsequent metastasis. EVs can easily be isolated from a variety of biological fluids, and their content makes them useful biomarkers for the diagnosis, prognosis, monito…
Learning non-linear time-scales with kernel -filters
2009
A family of kernel methods, based on the @c-filter structure, is presented for non-linear system identification and time series prediction. The kernel trick allows us to develop the natural non-linear extension of the (linear) support vector machine (SVM) @c-filter [G. Camps-Valls, M. Martinez-Ramon, J.L. Rojo-Alvarez, E. Soria-Olivas, Robust @c-filter using support vector machines, Neurocomput. J. 62(12) (2004) 493-499.], but this approach yields a rigid system model without non-linear cross relation between time-scales. Several functional analysis properties allow us to develop a full, principled family of kernel @c-filters. The improved performance in several application examples suggest…
Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence.
2020
Telomeres have the ability to adopt a lariat conformation and hence, engage in long and short distance intra-chromosome interactions. Budding yeast telomeres were proposed to fold back into subtelomeric regions, but a robust assay to quantitatively characterize this structure has been lacking. Therefore, it is not well understood how the interactions between telomeres and non-telomeric regions are established and regulated. We employ a telomere chromosome conformation capture (Telo-3C) approach to directly analyze telomere folding and its maintenance in S. cerevisiae. We identify the histone modifiers Sir2, Sin3 and Set2 as critical regulators for telomere folding, which suggests that a dis…
The histone deacetylase Rpd3 regulates the heterochromatin structure of Drosophila telomeres
2011
Telomeres are specialized structures at the end of eukaryotic chromosomes that are required to preserve genome integrity, chromosome stability and nuclear architecture. Telomere maintenance and function are established epigenetically in several eukaryotes. However, the exact chromatin enzymatic modifications regulating telomere homeostasis are poorly understood. In Drosophila melanogaster, telomere length and stability are maintained through the retrotransposition of specialized telomeric sequences and by the specific loading of protecting capping proteins, respectively. Here, we show that the loss of the essential and evolutionarily conserved histone deacetylase Rpd3, the homolog of mammal…
Cambios en las tendencias de la prescripción y causas de la interrupción en los tratamientos biológicos indicados en la psoriasis durante los primero…
2020
Resumen Antecedentes y objetivos Las guias sobre el tratamiento de la psoriasis habitualmente no incluyen las recomendaciones acerca de cual debe ser la primera linea de tratamiento sistemico o biologico. Los objetivos de este estudio fueron describir las tendencias en la prescripcion del primer farmaco biologico y comparar la retirada de los farmacos y las tasas de efectos adversos a lo largo de los 10 anos de seguimiento. Material y metodos Se utilizo el registro Biobadaderm para determinar cual fue el primer farmaco biologico indicado en pacientes con psoriasis naive para biologicos, asi como cual es la tasa de efectos adversos y los motivos de suspension de los farmacos. Los resultados …
Intermediate hosts of Angiostrongylus cantonensis in Tenerife, Spain.
2015
The nematode Angiostrongylus cantonensis is the causative agent of human angiostrongy- liasis, the main clinical manifestation of which is eosinophilic meningitis. Although this para- site has been found recently in its definitive rat host in Tenerife (Canary Islands, Spain), showing a widespread distribution over the north-east part of the island, there are no avail- able data regarding which snail and/or slug species are acting as intermediate hosts on this island. Consequently, the objective of this work was to determine the possible role of three mollusc species, Plutonia lamarckii , Cornu aspersum and Theba pisana , as intermediate hosts of A . cantonensis in Tenerife. Between 2011 and…
Cuatro años de la versión computerizada del Examen de Inglés como segunda lengua (TOEFL)
2009
Este artículo trata señalar las dificultades a las que se enfrentan los candidatos cuando realizan el examen de inglés como lengua extranjera (TOEFL) basado en Internet. El objetivo es doble: por un lado ver cómo se puede sugerir cómo evitar problemas similares en plataformas que ya se están diseñando en España (Proyecto PAULEX, MEC HUM2007-66479-C02-01/FILO) y, por otro, poner de relieve el tipo de preparación que necesitan los estudiantes que realicen este examen para poder superar ciertos problemas estratégicos que actualmente encuentran dichos candidatos.
Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis
2008
PON2 (paraoxonase-2) is a ubiquitously expressed antioxidative protein which is largely found in the ER (endoplasmic reticulum). Addressing the cytoprotective functions of PON2, we observed that PON2 overexpression provided significant resistance to ER-stress-induced caspase 3 activation when the ER stress was induced by interference with protein modification (by tunicamycin or dithiothreitol), but not when ER stress was induced by disturbance of Ca2+ homoeostasis (by thapsigargin or A23187). When analysing the underlying molecular events, we found an activation of the PON2 promoter in response to all tested ER-stress-inducing stimuli. However, only tunicamycin and dithiothreitol resulted i…
IL LEGISLATORE TEDESCO ALLARGA LE MAGLIE DELLA REVISIONE CONTRA REUM: L'ASSOLUZIONE PER DELITTI GRAVI E IMPRESCRITTIBILI PUÒ ESSERE MESSA IN DISCUSSI…
2022
Il legislatore tedesco ha ampliato il novero dei casi di revisione in peius. Ha previsto la possibilità di impugnare una sentenza definitiva di assoluzione per omicidio o crimini internazionali, qualora – in base a nuovi fatti o mezzi di prova – emergano “ragioni stringenti” per una condanna. La riforma ha già sollecitato dubbi di legittimità costituzionale e, per la sua rilevanza, suscita varie riflessioni.