Search results for "ASIS"
showing 10 items of 4190 documents
Yläkouluikäisten somalipoikien kokemuksia koululiikunnasta ja koulusta
2015
Tutkimuksen tarkoituksena oli selvittää yläkouluikäisten somalitaustaisten poikien kokemuksia koululiikunnasta ja koulusta. Tavoitteena oli saada tietoa siitä, miten somalitaustaisia oppilaita voidaan huomioida koululiikunnassa paremmin. Somalitaustaisten oppilaiden kokemusten pe-rusteella tutkimuksessa pyritään saamaan tietoa koululiikunnan ja koulun mielekkyydestä sekä siitä, miten liikuntatunneista voisi tehdä viihtyisämpiä oppilaille. Tutkimus oli menetelmälliseltä ratkaisultaan laadullinen, ja siinä oli piirteitä fenomenologis-hermeneuttisesta lähestymistavasta. Tutkimus toteutettiin haastattelemalla kuutta yläkoulussa opiskelevaa somalialaistaustaista oppilasta. Haastateltavat olivat …
Suomalaisen koululuokan monikulttuurinen todellisuus : etnografinen tapaustutkimus monikulttuurisuudesta, identiteetin rakentumisesta sekä vuorovaiku…
2015
Aivan tavalliset suomalaiset koululuokat ovat enenevässä määrin monikulttuurisia. Tämän tutkimuksen tarkoituksena oli luokkahuone-etnografian menetelmin selvittää, miten monikulttuurisuus ilmenee yhdessä suomalaisessa koululuokassa, miten se näkyy luokan vuorovaikutuksessa ja millaisia vaikutuksia sillä on oppilaiden identiteettiin sekä kokemuksiin toiseudesta ja osallisuudesta. Tutkimuksen painopiste on kansainväliseen liikkuvuuteen, etnisyyteen ja monikielisyyteen liittyvässä monikulttuurisuudessa. Oppilashaastattelujen, kirjoitelma-aineiston, havaintojen ja dokumenttien pohjalta suomalaisen koululuokan monikulttuurisesta todellisuudesta piirtyy värikäs kuva, joka heijastelee suomalaista …
Caracterización Fenética y Genética de Individuos del Género Fasciola Linnaeus, 1758 (Trematoda: Fasciolidae) de México
2017
La fascioliasis es una importante enfermedad causada por dos especies de trematodos, Fasciola hepatica y Fasciola gigantica, que incluye un amplio espectro de especies hospedadoras definitivas tanto domésticas como silvestres. En el presente trabajo, como primer paso, se realizó una revisión bibliográfica exhaustiva de todos los casos humanos de fascioliasis en México, reportados tanto en la literatura mexicana, como casos de pacientes mexicanos diagnosticados en Canadá y USA. El estudio fenético y genético se realizó con adultos del parásito, obtenidos de bovinos del matadero de la Ciudad de Toluca, Estado de México, México, zona de endemia humana. Para el estudio fenético comparativo se u…
The Comparison of Self-Perception of the Use of Learning Strategies in Spanish and Lithuanian Secondary Students When Learning Science
2021
Improving students‘ learning strategies is important for them in order to learn successfully. This article compares the self-perception of the use of learning strategies in Spanish and Lithuanian secondary schools students when learning science and analyse the students understanding of these strategies to determine the sociocultural environment influence on this perception. Results emphasize the need to include support actions to improve the management of strategies in secondary school.
Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myoki…
2021
Extracellular vesicles (EVs) have emerged as key players of intercellular communication and mediate crosstalk between tissues. Metastatic tumors release tumorigenic EVs, capable of pre-conditioning distal sites for organotropic metastasis. Growing evidence identifies muscle cell-derived EVs and myokines as potent mediators of cellular differentiation, proliferation, and metabolism. Muscle-derived EVs cargo myokines and other biological modulators like microRNAs, cytokines, chemokines, and prostaglandins hence, are likely to modulate the remodeling of niches in vital sites, such as liver and adipose tissues. Despite the scarcity of evidence to support a direct relationship between muscle-EVs…
ShRNA-mediated knock-down of CXCL8 inhibits tumor growth in colorectal liver metastasis.
2018
CXCL8 belongs to proinflammatory chemokines that are predominantly involved in neutrophil chemotaxis and degranulation. Several studies have suggested that secretion of CXCL8 from cancer cells have a profound effect on tumor microenvironment. In this study, in continuation to our previous work of understanding the global picture of invasion related genes in colorectal liver metastases, we clearly show an up-regulation of CXCL8 expression in the tumor cells at the invasion front as compared to the tumor cells in the inner parts of the tumor. Furthermore, ShRNA mediated down-regulation of CXCL8 resulted in inhibition of cell proliferation, viability and invasion in vitro and a near complete g…
Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro–Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice*
2016
Objectives:The gamma-aminobutyric acid modulator propofol induces neuronal cell death in healthy immature brains by unbalancing neurotrophin homeostasis via p75 neurotrophin receptor signaling. In adulthood, p75 neurotrophin receptor becomes down-regulated and propofol loses its neurotoxic effect. H
COX-2 expression in chondrosarcoma: A role for celecoxib treatment?
2010
Chondrosarcomas are resistant to conventional chemo- and radiotherapy. A subset of chondrosarcomas arises secondarily in the benign tumour syndromes enchondromatosis (EC) and multiple osteochondromas (MO), and prevention of tumour development would greatly improve prognosis. We therefore investigated the effect of selective COX-2 inhibition on chondrosarcoma growth. COX-2 expression was studied in central- and peripheral cartilaginous tumours. The effect of COX-2 inhibition was assessed in four high-grade chondrosarcoma cell lines using celecoxib and NS-398 treatment. COX-2 activity (prostaglandin E-2 (PGE(2)) ELISA) and cell viability were measured. The (prophylactic) effect of celecoxib o…
Patterns of trunk spine growth in two congeneric species of acanthocephalan: investment in attachment may differ between sexes and species.
2012
SUMMARYAcanthocephalans have evolved a hooked proboscis and some taxa have trunk spines to attach to their definitive hosts. These structures are generated before being used, thus a key question is how investment in attachment could optimally be allocated through the ontogeny. The number and arrangement of hooks and spines are never modified in the definitive host, but it is unclear whether these structures grow during adult development. A comparison of the size of trunk spines between cystacanths and adults of Corynosoma cetaceum and C. australe indicated that spines grow in both species, but only in females, which also had significantly larger spines than males. This sexual dimorphism did…
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease
2011
Cancer cell lines represent in vitro models for studying malignancies, general cell biology, drug discovery and more. Whether they can be considered as exact representative models of the parental tumors remains uncertain given the acquisition of additional ex vivo changes of the cells and the lack of tissue architecture and stroma. Previously, within the EuroBoNeT consortium, we characterized a collection of bone sarcoma cell lines on genomic and proteomic level. Here, we address the phenotypical and functional characterization of the unique set of osteosarcoma cell lines (n=19) in vitro and in vivo. For functional analysis of differentiation capacity, cells were stimulated towards osteobla…